Acute Kawasaki Disease: Not Just for Kids
- Case Reports/Case Vignettes
- Published:
- Volume 22, pages 681β684 (2007)
- Cite this article
Kawasaki Disease is a small-to-medium-vessel vasculitis that preferentially affects children. Kawasaki Disease can occur in adults, but the presentation may differ from that observed in children. Typical findings in both adults and children include fever, conjunctivitis, pharyngitis, and skin erythema progressing to a desquamating rash on the palms and soles. Adults more frequently present with cervical adenopathy (93% of adults vs. 15% of children), hepatitis (65% vs. 10%), and arthralgia (61% vs. 24β38%). In contrast, adults are less frequently affected by meningitis (10% vs. 34%), thrombocytosis (55% vs. 100%), and coronary artery aneurysms (5% vs. 18β25%). We report a case of acute Kawasaki Disease in a 24-year-old man who presented with rash, fever, and arthritis. He was successfully treated with high-dose aspirin and intravenous immunoglobulin (IVIG). Our case highlights the importance of considering Kawasaki Disease in adults presenting with symptoms commonly encountered in a general medical practice.
This is a preview of subscription content, to check access.
Access this article
Subscribe and save
- Starting from 10 chapters or articles per month
- Access and download chapters and articles from more than 300k books and 2,500 journals
- Cancel anytime
Buy Now
Price excludes VAT (USA)
Tax calculation will be finalised during checkout.
Instant access to the full article PDF.
Similar content being viewed by others
The Clinical Diagnosis and Management of Kawasaki Disease: a Review and Update
Kawasaki disease: two case reports from the Aga Khan Hospital, Dar es Salaam-Tanzania
Refractory Kawasaki Diseaseβa Challenge for the Pediatrician
Explore related subjects
Discover the latest articles, books and news in related subjects, suggested using machine learning.References
Newburger JW, Takahashi M, Gerber MA, et al. Diagnosis, treatment, and long-term management of Kawasaki Disease. Circulation. 2004;2747β71.
SΓ¨ve P, Stankovic K, Smail A, Durand DV, Marchand G, Broussolle C. Adult Kawasaki Disease: report of two cases and literature review. Semin Arthritis Rheum. 2005;34:785β92.
Yanagawa H, Nakamura Y, Yashiro M, et al. Incidence survey of Kawasaki Disease in 1997 and 1998 in Japan. Pediatrics. 2005;107:1β4.
Dillon MJ. Childhood vasculitis. Lupus. 1998;7:259β65.
Burns JC, Cayan DR, Tong G, et al. Seasonality and temporal clustering of Kawasaki Syndrome. Epidemiology. 2005;16:220β5.
Leung DY, Schlievert PM, Meissner HC. The immunopathogenesis and management of Kawasaki Syndrome. Arthritis Rheum. 1998;41:1538β47.
Long S. Principles and Practice of Pediatric Infectious Diseases 2nd edition: Chapter 14-Mucocutaneous Symptom Complexes. New York: Churchill Livingstone; 2003:103β8.
Falcini F, Trapani S, Turchini S, et al. Immunological findings in Kawasaki Disease: an evaluation in a cohort of Italian children. Clin Exp Rheumatol. 1997;15:685β9.
Rider LG, Wener MH, French J, Sherry DD, Mendelman PM. Autoantibody production in Kawasaki syndrome. Clin Exp Rheumatol. 1993;11:445β9.
Tomiyama J, Hasegawa Y, Kumagai Y, Adachi Y, Karasawa K. Acute febrile mucocutaneous lynph node syndrome (Kawasaki disease) in adults: case report and review of the literature. Jpn J Med. 1991;30:285β9.
Hansen KE, Arnason J, Bridges A. Autoantibodies and common viral illnesses. Semin Arthritis Rheum. 1998;27:263β71.
Leung DY, Giorno RC, Kazemi LV, Flynn PA, Busse JB. Evidence for superantigen involvement in cardiovascular injury due to Kawasaki Syndrome. J Immunol. 1995;155:5018-21.
Rauch AM, Glode MP, Wiggins JW, et al. Outbreak of Kawasaki Syndrome in Denver, Colorado: association with rug and carpet cleaning. Pediatrics. 1991;87:663β9.
Jackson JL, Kunkel MR, Libow L, Gates RH. Adult Kawasaki Disease: report of two cases treated with intravenous gamma globulin. Arch Intern Med. 1994;154:1398β405.
Rozo JC, Jefferies JL, Eidem BW, Cook PJ. Kawasaki Disease in the adult: a case report and review of the literature. Texas Heart Inst J. 2004;31:160β4.
Newburger JW, Takahashi M, Burns JC, et al. The treatment of Kawasaki Syndrome with intravenous gamma globulin. New Engl J Med. 1986;315:341β7.
Koren G, Rose V, Lavi S, Rowe R. Probable efficacy of high-dose salicylates in reducing coronary involvement in Kawasaki Disease. 1985;254:767β9.
Furusho K, Nakano H, Shinomiya K, et al. High dose intravenous gamma globulin for Kawasaki Disease. Lancet. 1984;2:1055β8.
Newburger JW, Takahasi M, Beiser AS, et al. A single intravenous infusion of gamma globulin as compared with four infusions in the treatment of acute Kawasaki Syndrome. New Engl J Med. 1991;324:1633β9.
Oates-Whitehead RM, Baumer JH, Haines L, et al. Intravenous immunoglobulin for the treatment of Kawasaki disease in children. Cochrane Database Syst Rev 2003;(4):CD004000.
Bayrou O, Phlippoteau C, Artigou C, Haddad T, Leynadier F. Adult Kawasaki syndrome associated with HIV infection and anti-cardiolipin antibodies. J Am Acad Dermatol. 1993;29:663β4.
Fason JT, Fry YW, Smith D. Kawasaki Disease in a postpartum patient. J Natl Med Assoc. 2004;96:1499β1502.
Kato H, Koike S, Yokoyama T. Kawasaki Disease: effect of treatment on coronary artery involvement. Pediatrics. 1979;63:175β9.
Sundel RP, Baker AL, Fulton DR, Newburger JW. Corticosteroids in the initial treatment of Kawasaki disease: report of a randomized trial. J Pediatr. 2003;142:611β6.
Wooditch AC, Aronoff SC. Effect of initial corticosteroid therapy on coronary artery aneurysm formation in Kawasaki disease: a meta-analysis of 862 children. Pediatrics. 2005;116:989.
Potential Financial Conflicts of Interest
None disclosed.
Rights and permissions
About this article
Cite this article
Wolff, A.E., Hansen, K.E. & Zakowski, L. Acute Kawasaki Disease: Not Just for Kids. J GEN INTERN MED 22, 681β684 (2007). https://doi.org/10.1007/s11606-006-0100-5
Published:
Issue date:
DOI: https://doi.org/10.1007/s11606-006-0100-5
Share this article
Anyone you share the following link with will be able to read this content:
Sorry, a shareable link is not currently available for this article.
Provided by the Springer Nature SharedIt content-sharing initiative
