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⇱ Selfish DNA: the ultimate parasite | Nature


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Abstract

The DNA of higher organisms usually falls into two classes, one specific and the other comparatively nonspecific. It seems plausible that most of the latter originated by the spreading of sequences which had little or no effect on the phenotype. We examine this idea from the point of view of the natural selection of preferred replicators within the genome.

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References

  1. Dawkins, R. The Selfish Gene (Oxford University Press, 1976).

    Google Scholar 

  2. Walker, P. M. B. in Human Genetics: Possibilities and Realities, 25–38 (Excepta Medica, Amsterdam, 1979).

    Google Scholar 

  3. Crick, F. H. C. in From Gene to Protein: Information Transfer in Normal and Abnormal Cells (eds Russell, T. R., Brew, K., Faber, H. & Schultz, J.) 1–13 (Academic, New York, 1979).

    Book  Google Scholar 

  4. Crick, F. H. C. Science 204, 264–271 (1979).

    Article  ADS  CAS  Google Scholar 

  5. Doolittle, W. F. & Sapienza, C. Nature 284, 601–603 (1980).

    Article  ADS  CAS  Google Scholar 

  6. Callan, H. G. J. Cell Sci. 2, 1–7 (1967).

    CAS  PubMed  Google Scholar 

  7. Thomas, C. A. A. Rev. Genet. 5, 237–256 (1971).

    Article  CAS  Google Scholar 

  8. Hinegardner, R. in Molecular Evolution (ed. Ayala, F. J.) 179–199 (Sinauer, Sunderland, 1976).

    Google Scholar 

  9. Commoner, B. Nature 202, 960–968 (1964).

    Article  ADS  CAS  Google Scholar 

  10. Ohno, S. J. hum. Evolut. 1, 651–662 (1972).

    Article  Google Scholar 

  11. Comings, D. E. Adv. hum. Genet. 3, 237–436 (1972).

    Article  CAS  Google Scholar 

  12. Cavalier-Smith, T. J. Cell Sci. 34, 274–278 (1978).

    Google Scholar 

  13. Galan, G. A., Chamberlin, M. E., Hough, B. R., Britten, R. J. & Davidson, E. H. in Molecular Evolution (ed. Ayala, F. J.) 200–224 (Sinauer, Sunderland, 1976).

    Google Scholar 

  14. Bishop, J. O. Cell 2, 81–86 (1974).

    Article  CAS  Google Scholar 

  15. Lewin, B. Cell 4, 11–20 (1975); Cell 4, 77–93 (1975).

    Article  CAS  Google Scholar 

  16. Lomedico, P. et al. Cell 18, 545–558 (1979).

    Article  CAS  Google Scholar 

  17. Bernards, R., Little, P. F. R., Annison, G., Williamson, R. & Flavell, R. A. Proc. natn. Acad. Sci. U.S.A. 76, 4827–4831 (1979).

    Article  ADS  CAS  Google Scholar 

  18. Crick, F. H. C. Eur. J. Biochem. 83, 1–3 (1978).

    Article  CAS  Google Scholar 

  19. Britten, R. J. & Davidson, E. H. Science 165, 349–358 (1969).

    Article  ADS  CAS  Google Scholar 

  20. Davidson, E. U. & Britten, R. J. Science 204, 1052–1059 (1979).

    Article  ADS  CAS  Google Scholar 

  21. Wilson, A. C. in Molecular Evolution (ed. Ayala, F. J.) 225–236 (Sinauer, Sunderland, 1976).

    Google Scholar 

  22. Bennett, M. D. Proc. R. Soc. B181, 109–135 (1972).

    ADS  CAS  Google Scholar 

  23. Bennett, M. D. & Smith, J. B. Proc. R. Soc. B181, 81–107 (1972).

    ADS  Google Scholar 

  24. Young, M. W. Proc. natn. Acad. Sci. U.S.A. 76, 6274–6278 (1979).

    Article  ADS  CAS  Google Scholar 

  25. Oeldorfe, E., Nishioka, M. & Bachmann, K. Sonderdr. Z.F. Zool., System Evolut. 16, 216–24 (1978).

    Article  Google Scholar 

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Authors and Affiliations

  1. The Salk Institute, 10010 N. Torrey Pines Road, La Jolla, California, 92037

    L. E. Orgel & F. H. C. Crick

Authors
  1. L. E. Orgel
  2. F. H. C. Crick

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Orgel, L., Crick, F. Selfish DNA: the ultimate parasite. Nature 284, 604–607 (1980). https://doi.org/10.1038/284604a0

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