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⇱ Impaired immune and acute-phase responses in interleukin-6-deficient mice | Nature

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Abstract

lNTERLEUKIN-6 (IL-6) is a multifunctional cytokine that regulates various aspects of the immune response, acute-phase reaction and haematopoiesis (for reviews see refs 1, 2). In vitro, leukaemia inhibitory factor, oncostatin M, ciliary neurotrophic factor and interleukin-11 display overlapping activities with IL-6. This functional redundancy may be explained by the interactions of specific binding receptors with a common signal-transducing receptor (gp130) (for reviews see refs 3, 4). To elucidate the unique function of IL-6 in vivo, we have disrupted the IL-6 gene by homologous recombination. IL-6-deficient mice develop normally. They fail to control efficiently vaccinia virus and infection with Listeria monocytogenes, a facultative intracellular bacterium. The T-cell-dependent antibody response against vesicular stomatitis virus is impaired. Further, the inflammatory acute-phase response after tissue damage or infection is severely compromised, whereas it is only moderately affected after challenge with lipopolysaccharide. We conclude that IL-6 production induced by injury or infection is an important in vivo SOS signal which coordinates activities of liver cells, macrophages and lymphocytes.

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Author information

Author notes

  1. Heinz Baumann: To whom correspondence should be addressed

Authors and Affiliations

  1. Max-Planck-lnstitut für Immunbiologie, Stübeweg 51, 79108, Freiburg, Germany

    Manfred Kopf, Marina Freudenberg, Marinus Lamers & Georges Köhler

  2. Department of Molecular and Cellular Biology, Roswell Park Cancer Institute, Buffalo, New York, 14263, USA

    Manfred Kopf & Georges Köhler

  3. Institut für Experimentelle Immunologie, Universität Zürich, Switzerland

    Giulia Freer & Rolf Zinkernagel

  4. Department of Biology, Hoffmann-La Roche AG, CH-4002, Basel, Switzerland

    Horst Bluethmann

  5. Department of Medicine III, Osaka University, Medical School, Osaka, 565, Japan

    Tadamitsu Kishimoto

Authors
  1. Manfred Kopf
  2. Heinz Baumann
  3. Giulia Freer
  4. Marina Freudenberg
  5. Marinus Lamers
  6. Tadamitsu Kishimoto
  7. Rolf Zinkernagel
  8. Horst Bluethmann
  9. Georges Köhler

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Cite this article

Kopf, M., Baumann, H., Freer, G. et al. Impaired immune and acute-phase responses in interleukin-6-deficient mice. Nature 368, 339–342 (1994). https://doi.org/10.1038/368339a0

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  • DOI: https://doi.org/10.1038/368339a0

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