The authors used fluorescence dissipation after photoactivation in three cell lines to measure kinetochore–microtubule attachment stability. They found that it was low in prometaphase and sharply increased between prometaphase and metaphase, indicating a coordinated switch in attachment stability during the prometaphase–metaphase transition. Furthermore, this was proteasome-dependent, suggesting that the degradation of proteins is required for this switch.
This study also defines prometaphase and metaphase as biochemically distinct cellular environments
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References
Kabeche, L. & Compton, D. A. Cyclin A regulates kinetochore microtubules to promote faithful chromosome segregation. Nature http://dx.doi.org/10.1038/nature12507 (2013)
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Baumann, K. Cyclin A corrections. Nat Rev Mol Cell Biol 14, 692 (2013). https://doi.org/10.1038/nrm3680
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DOI: https://doi.org/10.1038/nrm3680
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