Abstract
The single endogenous DBA/2J ecotropic provirus segregated concordantly with the dilute (d) coat colour mutation on chromosome 9 in 53/53 DBA/2J-derived recombinant inbred mouse strains and all seven inbred and mutant strains tested that carry the d allele. Analysis of DNA from a spontaneous DBA/2J d revenant (d+2J) showed that these mice lack ecotropic-specific MuLV DNA sequences and suggested that the dilute mutation resulted from integration of an ecotropic provirus into the mouse genome.
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References
Chattopadhyay, S. K., Lander, M. R., Rands, E. & Lowy, D. R. Proc. natn. Acad. Sci. U.S.A. 77, 5774β5778 (1980).
Steffen, D. L., Bird, S., Rowe, W. P. & Weinberg, R. A. Proc. natn. Acad. Sci. U.S.A. 76, 4554β4558 (1979).
Pincus, T. in Molecular Biology of RNA Tumor Viruses (ed. Stephenson, J. R.) 77β130 (Academic, New York, 1980).
Steffen, D. L., Bird, S. & Weinberg, R. A. J. Virol. 35, 824β835 (1980).
Rowe, W. P., Hartley, J. W. & Bremner, T. Science 178, 860β862 (1972).
Chattopadhyay, S. K., Rowe, W. P., Teich, N. M. & Lowy, D. R. Proc. natn. Acad. Sci. U.S.A. 72, 906β910 (1975).
Kozak, C. A. & Rowe, W. P. J. exp. Med. 152, 1419β1423 (1980).
Kozak, C. A. & Rowe, W. P. Science 204, 69β71 (1979).
Ihle, J. N., Joseph, D. R. & Dormotor, J. J. Science 204, 71β73 (1979).
Ihle, J. N. & Joseph, D. R. Virology 87, 298β306 (1978).
Kozak, C. A. & Rowe, W. P. in Animal Virus Genetics (eds Fields, B. & Jaenisch, R.) 171β176 (Academic, New York, 1980).
Taylor, B. A. in Origins of Inbred Mice (ed. Morse, H. C.) 423β438 (Academic, New York, 1978).
Steffen, D. L. et al. J. Virol. (submitted).
Rowe, W. P. & Kozak, C. A. Proc. natn. Acad. Sci. U.S.A. 77, 4871β4874 (1980).
Handbook on Genetically Standardized Jax Mice (The Jackson Laboratory, Bar Harbor, Maine, 1980).
Morse, H. C. in Origins of Inbred Mice (ed. Morse, H. C.) 3β21 (Academic, New York, 1978).
Wolf, H. G. & Coleman, D. L. in Biology of the Laboratory Mouse (ed. Green, E. L.) (McGraw-Hill, New York, 1966).
Schlager, G. & Dickie, M. M. Genetics 57, 319β330 (1967).
Farabaugh, P. J. & Fink, G. R. Nature 286, 352β356 (1980).
Rands, E., Lowy, D. R. Lander, M. R. & Chattopadhyay, S. K. Virology 108, 445β452 (1981).
Copeland, N. G., Zelenetz, A. D. & Cooper, G. M. Cell 19, 863β870 (1980).
Potter, S. S., Brorein, W. J., Dunsmuir, P. & Rubin, G. M. Cell 17, 415β427 (1979).
Rigby, P. W., Dieckmann, M., Rhodes, C. & Berg, P. J. molec. Biol. 113, 237β251 (1977).
Nadeau, J. H. et al. Biochem. Genet. (in the press).
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Jenkins, N., Copeland, N., Taylor, B. et al. Dilute (d) coat colour mutation of DBA/2J mice is associated with the site of integration of an ecotropic MuLV genome. Nature 293, 370β374 (1981). https://doi.org/10.1038/293370a0
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DOI: https://doi.org/10.1038/293370a0
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