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⇱ Intragenic ERBB2 kinase mutations in tumours | Nature

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Abstract

The protein-kinase family is the most frequently mutated gene family found in human cancer and faulty kinase enzymes are being investigated as promising targets for the design of antitumour therapies. We have sequenced the gene encoding the transmembrane protein tyrosine kinase ERBB2 (also known as HER2 or Neu) from 120 primary lung tumours and identified 4% that have mutations within the kinase domain; in the adenocarcinoma subtype of lung cancer, 10% of cases had mutations. ERBB2 inhibitors, which have so far proved to be ineffective in treating lung cancer, should now be clinically re-evaluated in the specific subset of patients with lung cancer whose tumours carry ERBB2 mutations.

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Figure 1: Similar positioning within the epidermal growth-factor receptor (EGFR) kinase domain (database accession numbers MMDB:20494/PDB:1M17) of the EGFR and ERBB2 mutations that are found in a proportion of lung tumours.

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References

  1. Sawyers, C. L. Genes Dev. 17, 2998–3010 (2002).

    Article  Google Scholar 

  2. Paez, J. G. et al. Science 304, 1497–1500 (2004).

    Article  ADS  CAS  Google Scholar 

  3. Lynch, T. J. et al. N. Engl. J. Med. 350, 2129–2139 (2004).

    Article  CAS  Google Scholar 

  4. Futreal, P. A. et al. Nature Rev. Cancer 4, 177–183 (2004).

    Article  CAS  Google Scholar 

  5. Slamon, D. J. et al. Science 235, 177–182 (1987).

    Article  ADS  CAS  Google Scholar 

  6. Klapper, S. et al. Adv. Cancer Res. 1, 25–79 (2000).

    Google Scholar 

  7. Hirsch, F. R. & Langer, C. J. Semin. Oncol. 31, 75–82 (2004).

    Article  CAS  Google Scholar 

  8. Rosell, R. J. Clin. Oncol. 22, 1171–1173 (2004).

    Article  ADS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Cancer Genome Project, Wellcome Trust Sanger Institute, Hinxton, CB10 1SA, UK

    Philip Stephens, Chris Hunter, Graham Bignell, Sarah Edkins, Helen Davies, Jon Teague, Claire Stevens, Sarah O'Meara, Raffaella Smith, Adrian Parker, Andy Barthorpe, Matthew Blow, Lisa Brackenbury, Adam Butler, Oliver Clarke, Jennifer Cole, Ed Dicks, Angus Dike, Anja Drozd, Ken Edwards, Simon Forbes, Rebecca Foster, Kristian Gray, Chris Greenman, Kelly Halliday, Katy Hills, Vivienne Kosmidou, Richard Lugg, Andy Menzies, Janet Perry, Robert Petty, Keiran Raine, Lewis Ratford, Rebecca Shepherd, Alexandra Small, Yvonne Stephens, Calli Tofts, Jennifer Varian, Sofie West, Sara Widaa, Andrew Yates, P. Andrew Futreal, Richard Wooster & Michael R. Stratton

  2. Ludwig Institute for Cancer Research, Brussels, 1200, Belgium

    Francis Brasseur

  3. Institute of Cancer Research, Sutton, SM2 5NG, UK

    Colin S. Cooper & Michael R. Stratton

  4. Institute of Orthopaedics, University College London, Stanmore, HA7 4LP, UK

    Adrienne M. Flanagan

  5. Cancer Research UK Clinical Centre, St James's University Hospital, Leeds, LS9 7TF, UK

    Margaret Knowles

  6. University of Hong Kong Department of Pathology, Queen Mary Hospital, Hong Kong

    Suet Y. Leung & Siu T. Yuen

  7. Massachusetts General Hospital East, Molecular Pathology Unit, Charlestown, 02129, Massachusetts, USA

    David N. Louis

  8. Laboratory of Pathology/Experimental Patho-Oncology, Erasmus MC University Medical Center Rotterdam, Daniel den Hoed Cancer Center, Josephine Nefkens Institute, Rotterdam, 3000 DR, The Netherlands

    Leendert H. J. Looijenga

  9. University of Pennsylvania Division of Urology, Philadelphia, 19104, Pennsylvania, USA

    Bruce Malkowicz

  10. Instituto Nazionale Tumori and FIRC Institute of Molecular Oncology, Milan, Italy

    Marco A. Pierotti

  11. Laboratory of Cancer Genetics, Van Andel Research Institute, Grand Rapids, 49503, Michigan, USA

    Bin Teh

  12. Queensland Institute of Medical Research, Royal Brisbane Hospital, Herston, 4029, Queensland, Australia

    Georgia Chenevix-Trench

  13. University of Pennsylvania Cancer Centre, Philadelphia, 19104-6160, Pennsylvania, USA

    Barbara L. Weber

  14. Royal Brompton Hospital, London, SW3 6NP, UK

    Grace Harris, Peter Goldstraw & Andrew G. Nicholson

  15. Cancer Genome Project and Collaborative Group,

    Philip Stephens

Authors
  1. Philip Stephens
  2. Chris Hunter
  3. Graham Bignell
  4. Sarah Edkins
  5. Helen Davies
  6. Jon Teague
  7. Claire Stevens
  8. Sarah O'Meara
  9. Raffaella Smith
  10. Adrian Parker
  11. Andy Barthorpe
  12. Matthew Blow
  13. Lisa Brackenbury
  14. Adam Butler
  15. Oliver Clarke
  16. Jennifer Cole
  17. Ed Dicks
  18. Angus Dike
  19. Anja Drozd
  20. Ken Edwards
  21. Simon Forbes
  22. Rebecca Foster
  23. Kristian Gray
  24. Chris Greenman
  25. Kelly Halliday
  26. Katy Hills
  27. Vivienne Kosmidou
  28. Richard Lugg
  29. Andy Menzies
  30. Janet Perry
  31. Robert Petty
  32. Keiran Raine
  33. Lewis Ratford
  34. Rebecca Shepherd
  35. Alexandra Small
  36. Yvonne Stephens
  37. Calli Tofts
  38. Jennifer Varian
  39. Sofie West
  40. Sara Widaa
  41. Andrew Yates
  42. Francis Brasseur
  43. Colin S. Cooper
  44. Adrienne M. Flanagan
  45. Margaret Knowles
  46. Suet Y. Leung
  47. David N. Louis
  48. Leendert H. J. Looijenga
  49. Bruce Malkowicz
  50. Marco A. Pierotti
  51. Bin Teh
  52. Georgia Chenevix-Trench
  53. Barbara L. Weber
  54. Siu T. Yuen
  55. Grace Harris
  56. Peter Goldstraw
  57. Andrew G. Nicholson
  58. P. Andrew Futreal
  59. Richard Wooster
  60. Michael R. Stratton

Corresponding author

Correspondence to P. Andrew Futreal.

Ethics declarations

Competing interests

The authors declare no competing financial interests.

About this article

Cite this article

Stephens, P., Hunter, C., Bignell, G. et al. Intragenic ERBB2 kinase mutations in tumours. Nature 431, 525–526 (2004). https://doi.org/10.1038/431525b

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  • DOI: https://doi.org/10.1038/431525b

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