ACM or A.C.M. may refer to:

• AGM-129 ACM, 1990–2012 USAF cruise missile
• Air chief marshal
• Air combat manoeuvring or dogfighting
• Air cycle machine
• IATA airport code for Arica Airport in Amazonas Department, Colombia

• Abstract Control Model, for USB to act as a serial port
• Association for Computing Machinery, a US-based international learned society for computing
• Asynchronous communication mechanism
• Audio Compression Manager, Microsoft Windows codec manager

• Allegany College of Maryland
• Associated Colleges of the Midwest
• Association for College Management

• Alcoholic cardiomyopathy, a disease of the heart muscle
• Arrhythmogenic cardiomyopathy, a disease of the heart muscle

• Academy of Contemporary Music, in Guildford, England, UK
• Academy of Country Music
• Association for Contemporary Music, in the Russian Federation

• African Content Movement, a South African political party
• Alliance for Community Media
• American Center for Mobility
• American Ceylon Mission
• Anaconda Copper Mining Company
• Anti-Coalition Militia, anti-NATO Taliban in Afghanistan
• Anti-cult movement
• Asian Civilisations Museum, Singapore
• Association for Computing Machinery, an international computing research society
• Association of Children's Museums
• Australasian Correctional Management
• Australian Community Media
• Australians for Constitutional Monarchy
• Netherlands Authority for Consumers and Markets (Dutch: Autoriteit Consument & Markt)

• Adaptive coding and modulation in wireless communication
• Advanced case management
• Alkyl acrylate copolymer, a type of rubber
• Aluminium composite material, used in sandwich panels
• Automated charging machine, a public mobile device charging station

• Another Chicago Magazine, a magazine founded by Barry Silesky
• Antônio Carlos Magalhães (1927-2007), Brazilian politician
• AC Milan, an Italian association football club
• AC Monza, an Italian association football club
• AECOM, NYSE symbol
• Asbestos-containing material
• Attorney–client matching
• Automobile Club de Monaco, a motoring club based in Monaco
• Iraqi Arabic, ISO 639-3 language code
• A US Navy hull classification symbol: Auxiliary minelayer (ACM)