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Protein-coding gene in humans
CHRNB3
Identifiers
AliasesCHRNB3, cholinergic receptor nicotinic beta 3 subunit
External IDsOMIM: 118508; MGI: 106212; HomoloGene: 36035; GeneCards: CHRNB3; OMA:CHRNB3 - orthologs
Gene location (Human)
👁 Chromosome 8 (human)
Chr.Chromosome 8 (human)[1]
Band8p11.21Start42,697,366 bp[1]
End42,737,407 bp[1]
Gene location (Mouse)
👁 Chromosome 8 (mouse)
Chr.Chromosome 8 (mouse)[2]
Band8|8 A2Start27,858,739 bp[2]
End27,889,758 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • testicle

  • pancreatic ductal cell

  • mucosa of ileum

  • tibialis anterior muscle

  • right testis

  • cerebellar cortex

  • cerebellar hemisphere

  • left testis

  • prefrontal cortex

  • substantia nigra
Top expressed in
  • neural layer of retina

  • inner nuclear layer

  • ganglion cell layer

  • habenula

  • outer nuclear layer

  • ventral tegmental area

  • primary visual cortex

  • spinal ganglia

  • meninges

  • superior frontal gyrus
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
Cellular component
Biological process
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

1142

108043

Ensembl

ENSG00000147432

ENSMUSG00000031492

UniProt

Q05901

Q8BMN3

RefSeq (mRNA)

NM_000749
NM_001347717

NM_027454
NM_173212

RefSeq (protein)

NP_000740
NP_001334646

NP_081730
NP_775304

Location (UCSC)Chr 8: 42.7 – 42.74 MbChr 8: 27.86 – 27.89 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Neuronal acetylcholine receptor subunit beta-3 is a protein that in humans is encoded by the CHRNB3 gene.[5][6] This gene has been identified as a candidate for predisposition to tobacco dependence.

See also

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References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000147432Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000031492Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Anand R, Lindstrom J (Sep 1992). "Chromosomal localization of seven neuronal nicotinic acetylcholine receptor subunit genes in humans". Genomics. 13 (4): 962–7. doi:10.1016/0888-7543(92)90008-G. PMID 1505988.
  6. ^ "Entrez Gene: CHRNB3 cholinergic receptor, nicotinic, beta 3".

Further reading

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External links

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This article incorporates text from the United States National Library of Medicine, which is in the public domain.