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Protein-coding gene in humans
CIRBP
πŸ‘ Image
Available structures
PDBOrtholog search: PDBe RCSB
List of PDB id codes

1X5S

Identifiers
AliasesCIRBP, CIRP, cold inducible RNA binding protein
External IDsOMIM: 602649; MGI: 893588; HomoloGene: 980; GeneCards: CIRBP; OMA:CIRBP - orthologs
Gene location (Human)
πŸ‘ Chromosome 19 (human)
Chr.Chromosome 19 (human)[1]
Band19p13.3Start1,259,384 bp[1]
End1,274,880 bp[1]
Gene location (Mouse)
πŸ‘ Chromosome 10 (mouse)
Chr.Chromosome 10 (mouse)[2]
Band10 C1|10 39.72 cMStart80,165,985 bp[2]
End80,172,786 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • tibia

  • corpus epididymis

  • caput epididymis

  • parietal pleura

  • germinal epithelium

  • right hemisphere of cerebellum

  • right uterine tube

  • anterior pituitary

  • middle temporal gyrus

  • left ovary
Top expressed in
  • neural layer of retina

  • lip

  • cerebellar cortex

  • molar

  • ventricular zone

  • spermatocyte

  • superior frontal gyrus

  • primary visual cortex

  • dorsomedial hypothalamic nucleus

  • paraventricular nucleus of hypothalamus
More reference expression data
BioGPS
πŸ‘ Image


πŸ‘ Image
More reference expression data
Gene ontology
Molecular function
Cellular component
Biological process
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

1153

12696

Ensembl

ENSG00000099622

ENSMUSG00000045193

UniProt

Q14011
Q53XX5

P60824

RefSeq (mRNA)

NM_001280
NM_001300815
NM_001300829

NM_007705

RefSeq (protein)

NP_001271
NP_001287744
NP_001287758
NP_001271.1

NP_031731
NP_001366350
NP_001366351
NP_001366352
NP_001366353

NP_001366354

Location (UCSC)Chr 19: 1.26 – 1.27 MbChr 10: 80.17 – 80.17 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Cold-inducible RNA-binding protein is a protein that in humans is encoded by the CIRBP gene.[5][6][7] The cold-inducible, RNA-binding protein CIRBP plays a critical role in controlling the cellular response upon confronting a variety of cellular stresses, including short wavelength ultraviolet light, hypoxia, and hypothermia. It is thought to be involved in DNA repair.[8]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000099622 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000045193 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Nishiyama H, Higashitsuji H, Yokoi H, Itoh K, Danno S, Matsuda T, et al. (December 1997). "Cloning and characterization of human CIRP (cold-inducible RNA-binding protein) cDNA and chromosomal assignment of the gene". Gene. 204 (1–2): 115–120. doi:10.1016/S0378-1119(97)00530-1. PMID 9434172.
  6. ^ Nishiyama H, Itoh K, Kaneko Y, Kishishita M, Yoshida O, Fujita J (May 1997). "A glycine-rich RNA-binding protein mediating cold-inducible suppression of mammalian cell growth". The Journal of Cell Biology. 137 (4): 899–908. doi:10.1083/jcb.137.4.899. PMC 2139845. PMID 9151692.
  7. ^ "Entrez Gene: CIRBP cold inducible RNA binding protein".
  8. ^ Firsanov D, Zacher M, Tian X, Sformo TL, Zhao Y, Tombline G, et al. (November 2024). "DNA repair and anti-cancer mechanisms in the long-lived bowhead whale". bioRxiv 10.1101/2023.05.07.539748.

External links

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Further reading

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