Disintegration or disintegrate may refer to:

• Disintegration (The Cure album), 1989
• Disintegration, by I've Sound, 2002
• Disintegrate (Zyklon album) or the title song, 2006

• "Disintegration" (The Cure song), 1989
• "Disintegrate", by The Amenta from Flesh Is Heir, 2013
• "Disintegrate", by Def Leppard from Euphoria, 1999
• "Disintegrate", by Faster Pussycat from The Power and the Glory Hole, 2006
• "Disintegrate", by Gravity Kills from Perversion, 1998
• "Disintegrate", by Suede from Antidepressants, 2025
• "Disintegrate", by Sylosis from Cycle of Suffering, 2020
• "Disintegration", by Edge of Sanity from Crimson II, 2003
• "Disintegration", by Henry Rollins from Nights Behind the Tree Line, 2004
• "Disintegration", by Jimmy Eat World from Stay on My Side Tonight, 2005
• "Disintegration", by Monarchy featuring Dita Von Teese, 2013
• "Disintegration", by Theatre of Tragedy from Storm, 2006
• "Disintegrator", by DJ Swamp, 1998

• Disintegration theorem, a mathematical result in measure theory and probability theory
• Nuclear disintegration, or nuclear decay, the result of radioactive decay

• The Disintegration (film), a 2011 drama film
• Disintegration (video game), a 2020 first-person shooter
• Disintegration ray, or raygun, a fictitious weapon
• Disintegration, a 1990 film; see List of the 100 best films in the history of Ukrainian cinema
• Disintegration, a 2018 short film directed by Buğra Mert Alkayalar

• Ablation
• Collapse (disambiguation)
• Decay chain, in nuclear science
• Derivative, in mathematics
• Integration (disambiguation)