Isaac (/ˈaɪzək/ EYE-zək) transliterated from Yitzhak, Yitzchok (Hebrew: יִצְחָק, Modern: Yīṣḥaq, Tiberian: Yīṣḥāq) was one of the three patriarchs in the Hebrew Bible, whose story is told in the book of Genesis.

Isaac is a given name derived from Judaism and a given name among Jewish, Christian, and Muslim societies, generally in reference to the above. "Ike" and "Ise" are also short forms of the name.

This is a selection of better known people with the name Isaac; for a comprehensive list, see All pages with titles beginning with Isaac.

• Saint Isaac (disambiguation), several people
• Isaac Abarbanel (1437–1508), Portuguese Jewish statesman and philosopher
• Isaac Acker (1821–1906), American politician from Pennsylvania
• Isaac Aguiar Tomich (born 2004), Brazilian footballer
• Isaac Alarcón (born 1998), Mexican American football player
• Isaac Albéniz (1860–1909), Spanish pianist and composer
• Isaac Alfasi (1013–1103), Algerian Talmudist and jurist
• Isaac II Angelos (1156–1204), Byzantine emperor
• Isaac of Armenia (354–439), Patriarch of the Armenian Apostolic Church
• Isaac Asiata (born 1992), American football player
• Isaac Asimov (1920–1992), Russian-born American writer and biochemist
• Isaac Babel (1894–1940), Russian journalist, playwright and short story writer
• Isaac Barrow (1630–1677), English theologian and mathematician
• Isaac Beeckman (1588–1637), Dutch philosopher and scientist
• Isaac de Benserade (1613–1691), French poet
• Isaac the Blind (c.1160–1235), French Jewish mysticist and Kabbalist
• Isaac Boleslavsky (1919–1977), Soviet chess grandmaster
• Isaac Bonga (born 1999), German basketball player
• Isaac Brock (1769–1812), British Army officer and colonial administrator
• Isaac Brock (musician) (born 1975), American lead singer in Modest Mouse
• Isaac Casaubon (1559–1614), French-born English classical scholar and philologist
• Isaac of the Cells, Egyptian Christian monk who lived during the 6th and 7th centuries
• Isaac Watts Choate (1882–1953), associate justice of the Montana Supreme Court
• Isaac da Costa (1798–1860), Dutch Jewish poet
• Isaac Cuenca (born 1991), Spanish footballer
• Isaac Dalby (1744–1824), English mathematician and surveyor
• Isaac Darkangelo (born 2000), American football player
• Isaac D'Israeli (1766–1848), British writer, scholar and man of letters
• Isaac Deutscher (1907–1967), Polish writer, journalist and political activist
• Isaac ben Eliezer, 15th-century German rabbi
• Isaac El Matari, jailed Australian ISIS leader from New South Wales.
• Isaac of Firuz Shabur, rabbi of the Geonic period
• Isaac Guerendo (born 2000), American football player
• Isaac Hanson (born 1980), American musician, guitarist in Hanson
• Isaac Hayes (1942–2008), American singer-songwriter, voice actor, and producer
• Isaac Israel Hayes (1832–1881), American Arctic explorer, physician and politician
• Isaac Hamilton (born 1994), American basketball player
• Isaac Heller (1926–2015), American toy manufacturer, co-founder of Remco
• Isaac Hempstead Wright (born 1999), English actor
• Isaac Herzog (born 1960), 11th President of Israel
• Isaac le Heup (c.1686–1747), British diplomat and politician
• Isaac Holloway (1805–1885), American politician from Ohio
• Isaac Isaacs (1855–1948), Australian Chief Justice and Governor-General
• Isaac Israeli ben Solomon (c. 832 – c. 932), Arab Jewish physician and philosopher
• Isaac Israëls (1865–1934), Dutch impressionist painter
• Isaac bar Judah, 4th-century Babylonian rabbi
• Isaac ben Judah, 12th-century rabbi
• Isaac ben Judah HaLevi, 13th-century French rabbi
• Isaac Kashdan (1905–1985), American chess grandmaster
• Isaac I Komnenos (c. 1007–1061), Byzantine emperor
• Isaac Komnenos (son of Alexios I) (1093 – aft. 1152), Byzantine prince
• Isaac Komnenos of Cyprus (c.1155–1196), ruler of Cyprus
• Isaac Kragten (born 2002), Canadian actor
• Isaac "Ike" Larsen (born 2003), American football player
• Isaac Lea (1792–1886), American publisher, conchologist and geologist
• Isaac Levitan (1860–1900), Russian landscape painter
• Isaac Luria (1534–1572), Jewish religious leader and mysticist
• Isaac Makwala (born 1986), Botswana sprinter
• Isaac McKneely (born 2003), American basketball player
• Isaac Musa (died 2008), Liberian military officer and politician
• Isaac Nappaha, Galilean rabbi of the 3rd-4th centuries
• Isaac Nauta (born 1997), American football player
• Isaac Newton (1642–1727), English mathematician, astronomer, and physicist
• Isaac R. Nicholson (1789/1790–1844), associate justice of the Supreme Court of Mississippi
• Isaac of Nineveh (c. 613 – c. 700), Syriac Christian bishop and theologian
• Isaac Okoro (born 2001), American basketball player
• Isaac Okoronkwo (born 1978), Nigerian footballer
• Isaac Oliver (c.1565–1617), French-born English portrait painter
• Isaac van Ostade (1621–1649), Dutch genre and landscape painter
• Isaac Peral (1851–1895), Spanish engineer, naval officer and designer of the Peral Submarine
• Isaac Leib Peretz (1852–1915), Yiddish writer from Poland
• Isaac Pitman (1813–1897), English inventor of shorthand/stenography
• Isaac Rex, American football player
• Isaac Roberts (1829–1904), Welsh amateur astronomer
• Isaac Rodrigues de Lima (born 2004), Brazilian footballer
• Isaac Rochell (born 1995), American football player
• Isaac Rosefelt (born 1985), American-Israeli basketball player
• Isaac Henrique Sequeira (1738–1816), Portuguese physician
• Isaac Shelby (1750–1826), Governor of Kentucky
• Isaac Singer (1811–1875), American inventor and businessman (sewing machine)
• Isaac Bashevis Singer (1902–1991), Polish-born American author, Nobel prize literature 1978
• Isaac Slade (born 1989), American lead singer in The Fray
• Isaac Stern (1920–2001), Ukrainian-born American violinist and conductor
• Isaac Taylor (1787–1865), English philosopher & historian
• Isaac Taylor (priest) (1829–1901), Anglican priest, philologist, toponymist
• Isaac TeSlaa (born 2002), American football player
• Isaac Titsingh (1745–1812), Dutch surgeon, scholar, merchant-trader and ambassador
• Isaac Inoke Tosika, Solomon Islands politician
• Isaac Ukwu (born 1999), American football player
• Isaac Vorsah (born 1988), Ghanaian footballer
• Isaac Watts (1674–1748), English Christian minister, hymn writer, theologian, and logician
• Isaac Wayne (1772–1856), U.S. Congressman
• Isaac Wayne (1699–1774), Pennsylvania Provincial Assembly member, Captain of Pennsylvania Provincial Forces during the French and Indian War
• Isaac White (basketball) (born 1998), Australian basketball player
• Isaac Witz (1934–2026), Austrian-born Israeli immunologist, cancer researcher and academic
• Isaac Yiadom (born 1996), American football player

• Isaach de Bankolé (born 1957), Ivorian actor

• Isaac, a character played by Ashley David in the British web series Corner Shop Show
• Isaac, the main antagonist from the video game Konami's Castlevania: Curse of Darkness and Nintendo's Devil's Third
• Isaac, the main protagonist in video games The Binding of Isaac and The Binding of Isaac: Rebirth
• Isaac, a main character in Nintendo's Golden Sun series
• Isaac, an android of extraterrestrial origin in American television series The Orville, played by Mark Jackson
• Isaac Bean, a Season 4 contestant in Fetch! with Ruff Ruffman
• Isaac Chroner, the main antagonist from the Stephen King short story Children of the Corn
• Isaac Clarke, the main protagonist from the Dead Space video game series
• Isaac Davis, Woody Allen's character in Manhattan
• Isaac Dian in the light novel and anime series Baccano!
• Isaac Harris in the Stephen King novella The Bazaar of Bad Dreams
• Isaac Heller, main antagonist from season 4 of Once Upon a Time
• Isaac Henderson in The Mummy
• Captain Isaac Higgintoot, an American Revolution officer in the CBS series Ghosts
• Isaac Kleiner in the video games Half-Life and Half-Life 2
• Isaac Lahey, in MTV's cult television series Teen Wolf, played by Daniel Sharman
• Isaac Mendez in the television series Heroes, played by Santiago Cabrera
• Isaac Netero in the manga series Hunter × Hunter
• Isaac Sumdac, a character from animated series Transformers Animated
• Isaac Washington, bartender on The Love Boat, played by Ted Lange

• Isaak Abelin (1883–1965), Swiss physiologist
• Isaak Asknaziy (1856–1902), Russian painter
• Isaak Bacharach (1854–1942), German mathematician
• Isaak Benrubi (1876–1943), Ottoman philosopher
• Isaak van den Blocke (1574–1626), Flemish painter in Poland
• Isaak Brodsky (1884–1939), Soviet painter
• Isaak Bubis (1910–2000), Moldavian Soviet engineer and architect
• Isaak August Dorner (1809–1884), German church leader
• Isaak Dunayevsky (1900–1955), Soviet composer
• Isaak Elias (1912–1998), Canadian politician
• Isaak Löw Hofmann, Edler von Hofmannsthal (1759–1849), Austrian merchant
• Isaak de Graaf (1668–1743), Dutch cartographer
• Isaak Guderian (born 1996), German singer
• Isaak Iselin (1728–1782), Swiss philosopher of history and politics
• Isaak Markus Jost (1793–1860), German Jewish historian
• Isaak Kikoin (1908–1984), Soviet physicist
• Isaak Markovich Khalatnikov (1919–2021), Soviet physicist
• Isaak B. Klejman (1921–2012), Ukrainian Soviet archaeologist
• Isaak Lalayants (1870–1933), Russian revolutionary
• Isaak Ah Mau (born 1982), New Zealand rugby league player
• Isaak D. Mayergoyz, American academic
• Isaak Mazepa (1884–1952), Ukrainian politician
• Isaak Moiseevich Milin (1919–1992), Soviet mathematician
• Isaak "Tjaak" Pattiwael (1914–1987), Indonesian footballer
• Isaak Pomeranchuk (1913–1966), Soviet physicist
• Isaak Illich Rubin (1886–1937), Soviet economist
• Isaak Augustijn Rumpf (1673–1723), Dutch Governor of Ceylon
• Isaak Tirion (1705–1765), Dutch publisher
• Isaak Voss (1618–1689), Dutch scholar and manuscript collector
• Isaak Yaglom (1921–1988), Soviet mathematician
• Isaak Zelensky (1890–1938), Soviet politician

• Isaak (Tekken), Character first introduced in Tekken Mobile
• Isaac (Golden Sun), Player character first introduced in Golden Sun

• Adèle Isaac (1854–1915), French operatic soprano
• Adisa Isaac (born 2001), American football player
• Alexandre Isaac (1845–1899), French lawyer, Senator of Guadeloupe 1885–1889
• Arthur Isaac (cricketer), English cricketer
• Auguste Isaac (1849–1938), French politician
• Bryan Isaac, British ballroom dancer
• Bobby Isaac, American racing driver
• Chris Isaak, American musician
• George Isaac (politician), Egyptian politician
• Glynn Isaac, South African archaeologist
• Heinrich Isaac (Ugonis, Henricus, Heinrich, Arrigo or Ysaac; c.1450–1517), Franco-Flemish composer
• John Isaac (cricketer), English cricketer
• Jonathan Isaac, American basketball player
• Luis Isaac, Puerto Rican baseball player
• Oscar Isaac, American actor
• Ray Isaac (quarterback), American football player
• Ray Isaac (singer), Australian singer
• Rhys Isaac, American historian
• Robert M. Isaac, American politician
• Ty Isaac, American football player
• Ashley MacIsaac, Canadian violinist

• Isaac (disambiguation)
• Isaacs (surname)
• Isaacson
• Ike (given name)
• Izak
• Ishak (name)