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Kitasamycin
Clinical data
👁 Image
Other names	Turimycin
AHFS/Drugs.com	International Drug Names
ATCvet code	QJ01FA93 (WHO)
Identifiers
IUPAC name [(4R,5S,6S,7R,9R,10R,11E,13E,16R)-6-{[(2S,3R,4R,5S,6R)-5-{[(2S,4R,5S,6S)-4,5-Dihydroxy-4,6-dimethyltetrahydro-2H-pyran-2-yl]oxy}-4-(dimethylamino)-3-hydroxy-6-methyltetrahydro-2H-pyran-2-yl]oxy}-4,10-dihydroxy-5-methoxy-9,16-dimethyl-2-oxooxacyclohexadeca-11,13-dien-7-yl]acetaldehyde (non-preferred name)
CAS Number	22875-15-6^{👁 check Y}
PubChem CID	5282189
ChemSpider	4445382^{👁 ☒ N}
UNII	VW9SY2S5WL
ChEMBL	ChEMBL1909061^{👁 ☒ N}
Chemical and physical data
Formula	C₃₅H₅₉NO₁₃
Molar mass	701.851 g·mol⁻¹
3D model (JSmol)	Interactive image
SMILES C[C@@H]1C/C=C/C=C/[C@@H]([C@@H](C[C@@H]([C@@H]([C@H]([C@@H](CC(=O)O1)O)OC)O[C@H]2[C@@H]([C@H]([C@@H]([C@H](O2)C)O[C@H]3C[C@@]([C@H]([C@@H](O3)C)O)(C)O)N(C)C)O)CC=O)C)O
InChI InChI=1S/C35H59NO13/c1-19-16-23(14-15-37)31(32(44-8)25(39)17-26(40)45-20(2)12-10-9-11-13-24(19)38)49-34-29(41)28(36(6)7)30(21(3)47-34)48-27-18-35(5,43)33(42)22(4)46-27/h9-11,13,15,19-25,27-34,38-39,41-43H,12,14,16-18H2,1-8H3/b10-9+,13-11+/t19-,20-,21-,22+,23+,24+,25-,27+,28-,29-,30-,31+,32+,33+,34+,35-/m1/s1^{👁 ☒ N} Key:XYJOGTQLTFNMQG-KJHBSLKPSA-N^{👁 ☒ N}
^{👁 ☒ N👁 check Y} (what is this?) (verify)

Kitasamycin (INN) is a macrolide antibiotic. It is produced by Streptomyces kitasatoensis.^[1] The drug has antimicrobial activity against a wide spectrum of pathogens. There are several generic names of this drug such as:^[2]

Kitasamycin (OS: BAN, JAN, USAN)
Kitasamycine (OS: DCF)
C 637 (IS)
Katasamycin (IS)
Leucomycin (IS)
Kitasamycin (PH: JP XV)
Kitasamycin Acetate (OS: JAN)
Leucomycin Acetate (IS)
Kitasamycin Acetate (PH: JP XV)
Kitasamycin Tartrate (OS: JAN)
Leucomycin Tartrate (IS)
Kitasamycin Tartrate (PH: JP XV)

References

[edit]

^ Zheng Q, Gao S (November 2016). "The effect of surfactant on fermentation of kitasamycin in Streptomyces kitasatoensis". Biotechnology and Applied Biochemistry. 63 (6): 895–900. doi:10.1002/bab.1443. PMID 26339801. S2CID 7290695.
^ "Kitasamycin". Drugs.com. Archived from the original on 20 October 2012.

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Antibacterials that inhibit protein synthesis (J01A, J01B, J01F, J01G, QJ01XQ)

30S

Aminoglycosides
(initiation inhibitors)

-mycin (Streptomyces)	Streptomycin^# Dihydrostreptomycin Neomycin^# Framycetin Paromomycin^# Ribostamycin Kanamycin Amikacin^# Arbekacin Bekanamycin Dibekacin Tobramycin (+loteprednol) Spectinomycin^# Hygromycin B Totomycin Apramycin Nourseothricin
-micin (Micromonospora)	Gentamicin^# Netilmicin Sisomicin Micronomicin Plazomicin^# Isepamicin Verdamicin Astromicin
other	Butirosin

Tetracycline antibiotics
(tRNA binding)

Tetracyclines	Doxycycline^# Chlortetracycline Clomocycline Demeclocycline Eravacycline Lymecycline Meclocycline^‡ Metacycline Minocycline Omadacycline Oxytetracycline Penimepicycline Rolitetracycline Sarecycline Tetracycline^#
Glycylcyclines	Tigecycline

50S

Oxazolidinone
(initiation inhibitors)

Peptidyl transferase

Amphenicols	Chloramphenicol^# Azidamfenicol Thiamphenicol Florfenicol

MLS (transpeptidation/translocation)

Macrolides	Boromycin Carbomycin Carrimycin Clarithromycin^# Dirithromycin Erythromycin^# Flurithromycin Josamycin Midecamycin Miocamycin Nafithromycin Oleandomycin Rokitamycin Roxithromycin Spiramycin Tildipirosin Tilmicosin Troleandomycin Tylosin Tylvalosin
Azalides	Azithromycin^# Gamithromycin Tulathromycin
Ketolides	Telithromycin^‡ Cethromycin Solithromycin^†
Lincosamides	Clindamycin^# Lincomycin Pirlimycin
Oxepanoprolinamides	Cresomycin Iboxamycin
Streptogramins	Pristinamycin (IA, IIA, IIB) NXL103 (Flopristin, Linopristin) Quinupristin/dalfopristin (Dalfopristin, Quinupristin) Streptogramin A Streptogramin B Virginiamycin (S1)

^#WHO-EM
^‡Withdrawn from market
Clinical trials:
- ^†Phase III
- ^§Never to phase III

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References