M22, M.22 or M-22 may refer to:

• BFW M.22, prototype, 1928 German bomber
• Jancsó-Szokolay M22, 1937 Hungarian sailplane
• Magni M-22 Voyager, autogyro
• Mooney M22 Mustang, 1964 American light aircraft
• Shvetsov M-22, a Soviet version of the Bristol Jupiter aircraft engine
• Russellville Municipal Airport (FAA LID: M22)

• M22 (New York City bus), a New York City Bus route in Manhattan
• Highway M22 (Ukraine)
• M-22 (Michigan highway), a state highway in Michigan
• M22 (Cape Town), a Metropolitan Route in Cape Town, South Africa
• M22 (Johannesburg), a Metropolitan Route in Johannesburg, South Africa
• M22 (Pretoria), a Metropolitan Route in Pretoria, South Africa
• M22 (Durban), a Metropolitan Route in Durban, South Africa
• M22 road (Malawi)
• M22 motorway (Northern Ireland)

• HMS M22, Royal Navy M15 class monitor; later HMS Media
• M22 Locust, a light tank of World War II
• M-22 Uragan/Shtil (SA-N-7, Gadfly), Soviet naval multirole SAM system
• M22, the US Army designation for a type of 7x50 binoculars produced by Steiner-Optik

• M 22, a political movement of the 1970s and 1980s in Congo-Brazzaville
• M22, a vitrification agent or cryoprotectant, used in cryonics and cryopreservation
• The Mathieu group M₂₂ in the mathematical field of group theory
• M₂₂ graph, in graph theory
• Messier 22, a globular cluster in the constellation Sagittarius
• Mälar 22, sailboat class
• M-22 (duo), a British-German DJ and producer duo consisting of Matt James and Frank Sanders.
• M22, an ISO metric screw thread size