MSSP may refer to:
- Managed Security Service Provider, who provides security services for companies
- Microsoft Smooth Streaming Protocol, a computer networking protocol designed to support adaptive media streaming
- Mobile Service Switching Point, see Service Switching Point
- Medicare Shared Savings Program, established by section 3022 of the Affordable Care Act
- Master Synchronous Serial Port, a module of a PIC microcontroller that is used for communication with other peripherals
- Missionary Society of St Paul (Malta)
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