PE may refer to:

• P/E cycle of flash memory
• Phase encoding, another name for Manchester code
• Portable Executable, a computer file format
• Windows Preinstallation Environment, a lightweight version of Microsoft Windows
• Progressive enhancement, a strategy for web design
• Protocol encryption, a feature of some peer-to-peer file-sharing clients
• Provider edge router, a router between computer networks
• Project Euler, a problem solving website

• Pectus excavatum, a structural deformity of the anterior thoracic wall in which the sternum and rib cage are shaped abnormally
• Pre-eclampsia, a disorder of pregnancy
• Premature ejaculation
• Pulmonary embolism, a blockage of the pulmonary artery

• Penis enlargement
• Phenylephrine, a common over-the-counter decongestant
• Phenytoin equivalent, used to measure doses of fosphenytoin
• Physical exercise
• Prolonged exposure therapy, a form of behavior therapy designed to treat posttraumatic stress disorder

• Pentaerythritol, a polyol
• Phenylephrine, a common over-the-counter decongestant
• Phenytoin equivalent, used to measure doses of fosphenytoin
• Phosphatidyl ethanolamine
• Phycoerythrin, a water-soluble protein used as a fluorescent marker in microscopy and flow cytometry
• Polyethylene, a common plastic polymer

• Positron emission, a type of radioactive decay
• Potential energy, the energy stored in a body or in a system due to its position in a force field or due to its configuration
• Proton emission, a type of radioactive decay
• Protective earth, a type of electrical protective system
• Reduction potential, the negative logarithm of electron activity

• AEG PE, a German World War I armored ground-attack aircraft
• Population equivalent, a concept used in sanitary engineering
• Present Era, a year numbering system commonly used in archaeology that uses 1950s as the epoch marker
• Professional Engineer, a post-nominal suffix indicating such a certification
• Primary energy, an energy form found in nature that has not been subjected to any human engineered conversion process
• A US Navy hull classification symbol: Patrol escort (PE)

• "P.E." (Cow and Chicken), a 1998 television episode
• Parasite Eve (video game), on the original PlayStation
• Pineapple Express (film), a 2008 American action-comedy film starring Seth Rogen
• Power electronics (music), a type of noise music
• The Press-Enterprise, a newspaper serving the Inland Empire in Southern California
• Private eye, a character class in the MMORPG Neocron
• Public Enemy (group), a hip hop group from Long Island, New York
• Minecraft: Pocket Edition, the mobile version of the video game

• P/E ratio, or price-to-earnings ratio
• Performance Evaluation, a journal
• Professional Engineer, a post-nominal suffix indicating such a certification
• Private equity, equity investments in companies that are not traded on a public stock exchange
• Permanent establishment, a fixed place of business establishing taxable presence of a business in a host country

• Air Europe Italy (IATA Code 1989–2008)
• People Express Airlines (1980s) (IATA Code 1981–1987)
• Pacific Electric, a defunct Los Angeles rail transit company
• PerkinElmer, an American technology company
• Army Police (Brazil), (Portuguese: Polícia do Exército) a Brazilian Army Police force
• Army Police (Portugal), (Portuguese: Polícia do Exército) a Portuguese Army Police force

• PE postcode area, UK, covering Peterborough
• Pernambuco, a state of Brazil
• Peru (ISO 3166-1 alpha-2 and NATO country code PE)
• Gqeberha, formerly known as Port Elizabeth, a city in South Africa
• Prince Edward Island, a Canadian province

• Pakistani English, the variant of English language spoken in Pakistan
• Physical education
• Princess Elizabeth Challenge Cup, a rowing event at Henley Royal Regatta

• Pe (disambiguation)
• Pee (disambiguation)