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RAB1B

Available structures

Ortholog search: PDBe RCSB

List of PDB id codes
3JZA, 3NKV, 4HLQ, 4I1O

Identifiers

Aliases

RAB1B, member RAS oncogene family

External IDs

OMIM: 612565; MGI: 1923558; HomoloGene: 128838; GeneCards: RAB1B; OMA:RAB1B - orthologs

Gene location (Human)
👁 Chromosome 11 (human)
Chr.	Chromosome 11 (human)^[1]
👁 Chromosome 11 (human) 👁 Genomic location for RAB1B 👁 Genomic location for RAB1B
Band	11q13.2	Start	66,268,590 bp^[1]
Band	11q13.2	End	66,277,492 bp^[1]

Gene location (Mouse)
👁 Chromosome 19 (mouse)
Chr.	Chromosome 19 (mouse)^[2]
👁 Chromosome 19 (mouse) 👁 Genomic location for RAB1B 👁 Genomic location for RAB1B
Band	19\|19 A	Start	5,149,233 bp^[2]
Band	19\|19 A	End	5,157,100 bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

mucosa of transverse colon

apex of heart

skin of leg

body of stomach

gastrocnemius muscle

right adrenal gland

right coronary artery

right adrenal cortex

popliteal artery

left coronary artery

Top expressed in

right kidney

granulocyte

muscle of thigh

yolk sac

dentate gyrus of hippocampal formation granule cell

ventricular zone

superior frontal gyrus

spermatocyte

primary visual cortex

More reference expression data

BioGPS

👁 Image
More reference expression data

Gene ontology
Molecular function	nucleotide binding GTP binding protein binding GTPase activity
Cellular component	cytoplasm phagophore assembly site membrane Golgi apparatus membrane Golgi membrane transport vesicle mitochondrion extracellular exosome endoplasmic reticulum-Golgi intermediate compartment membrane endoplasmic reticulum-Golgi intermediate compartment endoplasmic reticulum membrane cytosol perinuclear region of cytoplasm
Biological process	establishment of endothelial intestinal barrier positive regulation of glycoprotein metabolic process autophagy regulation of autophagosome assembly endoplasmic reticulum to Golgi vesicle-mediated transport COPII vesicle coating protein transport retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum post-translational protein modification transport intracellular protein transport Rab protein signal transduction
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


81876


76308

Ensembl


ENSG00000174903


ENSMUSG00000024870

UniProt


Q9H0U4


Q9D1G1

RefSeq (mRNA)


NM_030981


NM_029576

RefSeq (protein)


NP_112243


NP_083852

Location (UCSC)

Chr 11: 66.27 – 66.28 Mb

Chr 19: 5.15 – 5.16 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

Ras-related protein Rab-1B is a protein that in humans is encoded by the RAB1B gene.^[5]^[6]

Interactions

[edit]

RAB1B has been shown to interact with GOLGA2.^[7]

References

[edit]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000174903 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000024870 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Chen D, Guo J, Gahl WA (March 1997). "RAB GTPases expressed in human melanoma cells". Biochim Biophys Acta. 1355 (1): 1–6. doi:10.1016/S0167-4889(96)00169-3. PMID 9030196.
^ "Entrez Gene: RAB1B RAB1B, member RAS oncogene family".
^ Weide, T; Bayer M; Köster M; Siebrasse J P; Peters R; Barnekow A (April 2001). "The Golgi matrix protein GM130: a specific interacting partner of the small GTPase rab1b". EMBO Rep. 2 (4). England: 336–41. doi:10.1093/embo-reports/kve065. ISSN 1469-221X. PMC 1083862. PMID 11306556.

Plutner H, Cox AD, Pind S, et al. (1991). "Rab1b regulates vesicular transport between the endoplasmic reticulum and successive Golgi compartments". J. Cell Biol. 115 (1): 31–43. doi:10.1083/jcb.115.1.31. PMC 2289927. PMID 1918138.
Soldati T, Rancaño C, Geissler H, Pfeffer SR (1995). "Rab7 and Rab9 are recruited onto late endosomes by biochemically distinguishable processes". J. Biol. Chem. 270 (43): 25541–8. doi:10.1074/jbc.270.43.25541. PMID 7592724.
Wilson AL, Sheridan KM, Erdman RA, Maltese WA (1996). "Prenylation of a Rab1B mutant with altered GTPase activity is impaired in cell-free systems but not in intact mammalian cells". Biochem. J. 318 (Pt 3): 1007–14. doi:10.1042/bj3181007. PMC 1217717. PMID 8836150.
Overmeyer JH, Wilson AL, Erdman RA, Maltese WA (1998). "The Putative "Switch 2" Domain of the Ras-related GTPase, Rab1B, Plays an Essential Role in the Interaction with Rab Escort Protein". Mol. Biol. Cell. 9 (1): 223–35. doi:10.1091/mbc.9.1.223. PMC 25245. PMID 9437002.
Weide T, Koster M, Barnekow A (1999). "Inactive and active mutants of rab1b are not tightly integrated into target membranes". Int. J. Oncol. 15 (4): 727–36. doi:10.3892/ijo.15.4.727. PMID 10493955.
Hartley JL, Temple GF, Brasch MA (2001). "DNA Cloning Using In Vitro Site-Specific Recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a Catalog of Human Genes and Proteins: Sequencing and Analysis of 500 Novel Complete Protein Coding Human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
Simpson JC, Wellenreuther R, Poustka A, et al. (2001). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing". EMBO Rep. 1 (3): 287–92. doi:10.1093/embo-reports/kvd058. PMC 1083732. PMID 11256614.
Weide T, Bayer M, Köster M, et al. (2001). "The Golgi matrix protein GM130: a specific interacting partner of the small GTPase rab1b". EMBO Rep. 2 (4): 336–41. doi:10.1093/embo-reports/kve065. PMC 1083862. PMID 11306556.
Zhao H, Ettala O, Väänänen HK (2002). "Intracellular membrane trafficking pathways in bone-resorbing osteoclasts revealed by cloning and subcellular localization studies of small GTP-binding rab proteins". Biochem. Biophys. Res. Commun. 293 (3): 1060–5. doi:10.1016/S0006-291X(02)00326-1. PMID 12051767.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to Biology: A Functional Genomics Pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
Fischer J, Weide T, Barnekow A (2005). "The MICAL proteins and rab1: a possible link to the cytoskeleton?". Biochem. Biophys. Res. Commun. 328 (2): 415–23. doi:10.1016/j.bbrc.2004.12.182. PMID 15694364.
Bayer M, Fischer J, Kremerskothen J, et al. (2006). "Identification and characterization of Iporin as a novel interaction partner for rab1". BMC Cell Biol. 6 (1): 15. doi:10.1186/1471-2121-6-15. PMC 1079803. PMID 15796781.
Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.
Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein–protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.
Monetta P, Slavin I, Romero N, Alvarez C (2007). "Rab1b Interacts with GBF1 and Modulates both ARF1 Dynamics and COPI Association". Mol. Biol. Cell. 18 (7): 2400–10. doi:10.1091/mbc.E06-11-1005. PMC 1924811. PMID 17429068.
Machner MP, Isberg RR (2007). "A bifunctional bacterial protein links GDI displacement to Rab1 activation". Science. 318 (5852): 974–7. Bibcode:2007Sci...318..974M. doi:10.1126/science.1149121. PMID 17947549. S2CID 21889766.

v t e PDB gallery
👁 2fol: Crystal structure of human RAB1A in complex with GDP 2fol: Crystal structure of human RAB1A in complex with GDP

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References

Further reading