A she-wolf is a female gray wolf (Canis lupus).

She-wolf or she wolf may also refer to:

• She-wolf (Roman mythology), from the tale of Romulus and Remus, a traditional symbol of Rome
• Isabella of France (1295–1358), wife of Edward II popularly known as the "she-wolf"
• Margaret of Anjou (1430–1482), wife of Henry VI - called "She-wolf of France but worse" in Shakespeare's Henry VI

• She-Wolf of the Capitol, or Capitoline Wolf, a bronze sculpture inspired by the founding legend of Rome
• The She-Wolf, a 1943 post-surrealist painting by Jackson Pollock

• "The She-Wolf", a story by Saki from the 1914 book Beasts and Super-Beasts
• "La Lupa" (short story) ("The She-Wolf"), a short story by Giovanni Verga

• The She Wolf (1919 film), an American silent short western film
• The She-Wolf (1931 film), an American drama film
• The She-Wolf (1951 film), a Greek film
• La lupa (1953 film), also known as She-wolf, an Italian film by director Alberto Lattuada based on the short story by Giovanni Verga
• The She-Wolf (1965 film) (Spanish: La Loba), a Spanish-language film directed by Rafael Baledón
• Ilsa, She Wolf of the SS, a 1975 Nazisploitation film
• She-Wolf (1983 film) [pl], Polish film by Marek Piestrak
• La lupa (1996 film), also known as The She Wolf, an Italian film by Gabriele Lavia based on the short story by Giovanni Verga

• She Wolf: The Last Sentinel, a Philippine fantasy horror television series
• She-Wolf (TV series), a 1990s horror fiction television series

• She Wolf (album), a 2009 dance-pop album by Shakira
• "She Wolf" (Shakira song), the title track from the album
• "She Wolf (Falling to Pieces)", a single by David Guetta from the 2012 album Nothing but the Beat 2.0
• She-Wolf, a 1981 country blues album by Jessie Mae Hemphill
• "She-Wolf", a song by Megadeth from the 1997 album Cryptic Writings

• La lupa (disambiguation)
• Loba (disambiguation)
• Romulus and Remus