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TCF15

Identifiers

TCF15, EC2, PARAXIS, bHLHa40, transcription factor 15 (basic helix-loop-helix), transcription factor 15

External IDs

OMIM: 601010; MGI: 104664; HomoloGene: 37943; GeneCards: TCF15; OMA:TCF15 - orthologs

Gene location (Human)
👁 Chromosome 20 (human)
Chr.	Chromosome 20 (human)^[1]
👁 Chromosome 20 (human) 👁 Genomic location for TCF15 👁 Genomic location for TCF15
Band	20p13	Start	604,257 bp^[1]
Band	20p13	End	610,309 bp^[1]

Gene location (Mouse)
👁 Chromosome 2 (mouse)
Chr.	Chromosome 2 (mouse)^[2]
👁 Chromosome 2 (mouse) 👁 Genomic location for TCF15 👁 Genomic location for TCF15
Band	2 G3\|2 74.83 cM	Start	151,985,481 bp^[2]
Band	2 G3\|2 74.83 cM	End	151,991,017 bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

right ventricle

apex of heart

vena cava

glutes

Skeletal muscle tissue of biceps brachii

dorsal motor nucleus of vagus nerve

Skeletal muscle tissue of rectus abdominis

body of tongue

left ventricle

gonad

Top expressed in

somite

digastric muscle

sclerotome

sternocleidomastoid muscle

masseter muscle

tibialis anterior muscle

intercostal muscle

interventricular septum

myocardium of ventricle

triceps brachii muscle

More reference expression data

BioGPS

n/a

Gene ontology
Molecular function	DNA binding protein dimerization activity DNA-binding transcription factor activity RNA polymerase II cis-regulatory region sequence-specific DNA binding DNA-binding transcription activator activity, RNA polymerase II-specific DNA-binding transcription factor activity, RNA polymerase II-specific
Cellular component	nucleus RNA polymerase II transcription regulator complex
Biological process	somitogenesis respiratory system process regulation of transcription, DNA-templated muscle organ morphogenesis eating behavior neuromuscular process controlling posture regulation of transcription by RNA polymerase II skeletal system morphogenesis muscle organ development ear development transcription, DNA-templated multicellular organism development establishment of epithelial cell apical/basal polarity regulation of extracellular matrix organization post-anal tail morphogenesis regulation of gene expression mesoderm development anterior/posterior pattern specification skin development paraxial mesoderm development mesenchymal to epithelial transition transcription by RNA polymerase II positive regulation of transcription by RNA polymerase II
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


6939


21407

Ensembl


ENSG00000125878


ENSMUSG00000068079

UniProt


Q12870


Q60756

RefSeq (mRNA)


NM_004609


NM_009328

RefSeq (protein)


NP_004600


NP_033354

Location (UCSC)

Chr 20: 0.6 – 0.61 Mb

Chr 2: 151.99 – 151.99 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

Transcription factor 15 (TCF-15) also known as Paraxis, is a protein that in humans is encoded by the TCF15 gene.^[5]

Function

[edit]

Transcription factor 15 is found in the nucleus and is involved in the early transcriptional regulation of patterning of the mesoderm, and has a key role in somitogenesis.^[6] The encoded basic helix-loop-helix protein requires dimerization with another basic helix-loop-helix protein for efficient DNA binding. [provided by RefSeq, Jul 2008].

References

[edit]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000125878 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000068079 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: Transcription factor 15". Retrieved 2017-11-09.
^ "TCF15". UniProt. Retrieved 29 June 2025.

URL: https://en.wikipedia.org/wiki/TCF15

⇱ Transcription factor 15 - Wikipedia

Function

References

Further reading