Wynne is a surname of Welsh origin. This is a list of notable people with the surname, sorted by profession:

• Bill Wynne (1922–2021), American photographer and writer
• David Wynne (composer) (1900–1983), Welsh composer
• David Wynne (sculptor) (1926–2014), British sculptor
• Frank Wynne (born 1962), Irish translator and writer
• Ed Wynne (born 1961), British musician and son of sculptor David Wynne
• Ed Wynne (saxophonist), musician with the Doobie Brothers
• Gladys Wynne, Irish watercolour artist
• Giustiniana Wynne (1737–1791), Anglo-Venetian author, aka Countess Orsini-Rosenberg of Austria
• Madeline Yale Wynne (1847−1918), American artist, teacher, and philanthropist
• Michael Wynne (playwright), British playwright
• Nick Wynne (born 1943), American historian, educator, writer
• Philippé Wynne (1941–1984), American R&B vocalist
• Richard Wynne (c.1821–1895), Australian arts benefactor, established Wynne Prize
• Sina Wynne Holwerda (born 1997), American rapper known professionally as Wynne

• Ian Wynne (born 1973), British flatwater canoeist
• John Wynne (ice hockey) (born 1971), Canadian ice hockey defenceman
• Marvell Wynne (baseball player) (born 1959), American baseball outfielder
• Marvell Wynne (soccer) (born 1986), American football player
• Susan Wynne (fl. 1987–94), American figure skater

• Sir Arthur Singleton Wynne (1846–1936), British army general from Ireland
• Edward Wynne (chancellor) (1681–1755), Welsh lawyer and landowner
• Edward Wynne (colonial governor) (fl. 1621–26), early Newfoundland colonist, proprietary governor of the Ferryland colony from 1621 to 1626
• Edward Wynne (jurist) (1734–1784), English lawyer and scholar
• Edward Wynne-Pendarves (1775–1853), British politician
• Greville Wynne (1919–90), British spy
• Kathleen Wynne (born 1953), Canadian politician - Premier of Ontario
• Khalid Shameem Wynne (1953–2017), Pakistani four-star general and Chairman of the Joint Chiefs of Staff Committee
• Michael Wynne (born 1944), American businessman, Secretary of the Air Force
• Robert Wynne (1851–1922), American politician
• Robert Wynne (Virginia politician) (1622–75), Virginia colonial politician, Speaker of the Virginia House of Burgesses
• William Watkin Edward Wynne (1801–1880), Welsh politician and antiquarian

• Angus G. Wynne (1914–1979), American businessman, founder of Six Flags theme parks
• Arthur Wynne (1862–1945), English-American inventor of the crossword puzzle
• Arthur Beavor Wynne (1837–1906), Irish geologist
• Billy Wynne (1919-2000), Church of Ireland cleric & founder of the Samaritans in Ireland
• Ellis Wynne (1671–1734), Welsh clergyman
• Emanuel Wynne (fl. c. 1700), French pirate
• Henry John Wynne (1864–1950), New Zealand engineer
• Ivor Wynne (1918–1970), Welsh-Canadian educator and university administrator
• Jane Wynne (1944–2009), English paediatrician
• Jay Wynne (1968–2025), British television & radio weather forecaster
• Lyman Wynne (1925–2007), American psychiatrist and psychologist
• Owen Wynne (disambiguation), several people of this name
• Robert Wynne (1833-1912), Church of Ireland cleric and author

• Wynne (disambiguation)
• Wynn (disambiguation)
• Wyn, a surname
• Wyne (disambiguation)