NE, Ne or ne may refer to:

• Neutral Evil, an alignment in the American role-playing game Dungeons & Dragons
• New Edition, an American vocal group
• Nicomachean Ethics, a collection of ten books by Greek philosopher Aristotle

• Mobico Group, formerly National Express, an English public transport operator
• Natural England, an English government agency
• New England Patriots, a professional American football team in Foxborough, Massachusetts
• New Hope (Macau), a Macau political party
• SkyEurope Airlines, a Slovak airline
• New Era Cap Company, an American headwear company

• Ne (cuneiform), a cuneiform sign
• Ne (kana), a Japanese written character
• Nepali language
• Modern English, sometimes abbreviated NE (to avoid confusion with Middle English)

• NE postcode area, UK, a postcode for the City of Newcastle upon Tyne, Tyne and Wear
• Ne, Liguria, Italy, a comune in the Province of Genoa
• Né (river), a river in southwestern France
• Near East
• Niger, ISO 3166-1 country code
  • .ne, the country code top level domain (ccTLD) for Niger
• Canton of Neuchâtel, a canton of Switzerland
• Nebraska, US (postal abbreviation)
• New England, a region of the United States consisting of six states

• .ne, the country code top level domain (ccTLD) for Niger
• ne (text editor), a console text editor
• NE (complexity), a class in computational complexity theory
• Network element, a manageable logical entity uniting one or more physical devices
• New Executable, a computer file format

• Electron density (👁 {\displaystyle n_{e}}
  )
• N_e, effective population size
• Ne, for Number English, a unit of measure for cotton fiber
• Inequality operator, a term used in programming languages as a "not equal to" operator
• Nash equilibrium, a solution concept in game theory
• Neon, symbol Ne, a chemical element
• Norepinephrine, a neurotransmitter

• N.E. and N.E.2d, abbreviations for North Eastern Reporter, US law reports
• Né, indicating the name given to a male child at birth, equivalent to the feminine née
• Nationalencyklopedin, a Swedish national encyclopedia
• Nitro Express, a brand of rifle cartridges
• Northeast (direction), one of the four ordinal directions