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URL: https://enzyme.expasy.org/EC/3.4.17.23

⇱ ENZYME - 3.4.17.23 angiotensin-converting enzyme 2

ENZYME entry: EC 3.4.17.23

PURL: https://purl.expasy.org/enzyme/EC/3.4.17.23
Accepted Name
angiotensin-converting enzyme 2
Alternative Name(s)
ACE2
angiotensin converting enzyme 2
angiotensin converting enzyme-2
Reaction catalysed
angiotensin II + H2O = angiotensin-(1-7) + L-phenylalanine
Comment(s)
  • A transmembrane glycoprotein with an extracellular catalytic domain.
  • Angiotensin-converting enzyme 2 functions as a carboxypeptidase, cleaving a single C-terminal residue from a distinct range of substrates.
  • Catalytic efficiency is 400-fold higher with angiotensin II (1-8) as a substrate than with angiotensin I (1-10).
  • Angiotensin-converting enzyme 2 also efficiently hydrolyzes des- Arg(9)-bradykinin, but it does not hydrolyze bradykinin.
  • Belongs to peptidase family M2.
Cross-references
Rhea expert-curated reactions3.4.17.23
ExplorEnz3.4.17.23
IUBMB Enzyme Nomenclature3.4.17.23
UniProtKB/Swiss-Prot
Q58DD0, ACE2_BOVINQ56H28, ACE2_FELCAQ9BYF1, ACE2_HUMAN
Q8R0I0, ACE2_MOUSEQ56NL1, ACE2_PAGLAQ5RFN1, ACE2_PONAB
Q5EGZ1, ACE2_RAT
BRENDA3.4.17.23
MetaCyc3.4.17.23
KEGG Ligand Database for Enzyme Nomenclature3.4.17.23
EC2PDB3.4.17.23
MEDLINEFind literature relating to 3.4.17.23

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