entry stringlengths 6 10 | cc_function stringlengths 75 10.3k | question stringlengths 58 156 |
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A0A009IHW8 | FUNCTION: NAD(+) hydrolase (NADase) that catalyzes cleavage of NAD(+) into ADP-D-ribose (ADPR) and nicotinamide (PubMed:29395922). In addition to ADPR, also generates a cyclization variant of cyclic ADPR (cADPR), termed 2'cADPR (v-cADPR) (PubMed:29395922, PubMed:36048923). Cleaves NADP(+), but does not cyclize the prod... | I need a protein that cleaves NAD+ into ADP-ribose and nicotinamide. |
A0A023I7E1 | FUNCTION: Cleaves internal linkages in 1,3-beta-glucan. {ECO:0000269|PubMed:34801773}. | Find me a protein that cleaves internal linkages in 1,3-beta-glucan. |
A0A024B7W1 | FUNCTION: [Capsid protein C]: Capsid protein C self-assembles to form an icosahedral capsid about 30 nm in diameter. The capsid encapsulates the genomic RNA (Probable). Plays a role in virus budding by binding to the cell membrane and gathering the viral RNA into a nucleocapsid that forms the core of the mature virus p... | I would like a protein that self-assembles into an icosahedral viral capsid of about 30 nm. |
A0A024RXP8 | FUNCTION: Exocellobiohydrolases (CBH) that catalyzes the hydrolysis of 1,4-beta-D-glucosidic bonds in cellulose to release the disaccharide cellobiose. The degradation of cellulose involves an interplay between different cellulolytic enzymes. Hydrolysis starts with endoglucanases (EGs), which cut internal beta-1,4-gluc... | Give me a protein that hydrolyzes beta-1,4-glucosidic bonds in cellulose to release cellobiose. |
A0A024SC78 | FUNCTION: Catalyzes the hydrolysis of complex carboxylic polyesters found in the cell wall of plants (PubMed:25219509). Degrades cutin, a macromolecule that forms the structure of the plant cuticle (PubMed:25219509). {ECO:0000269|PubMed:25219509}. | I am looking for a protein that hydrolyzes complex carboxylic polyesters found in plant cell walls. |
A0A024SH76 | FUNCTION: Exocellobiohydrolases (CBH) that catalyzes the hydrolysis of 1,4-beta-D-glucosidic bonds in cellulose to release the disaccharide cellobiose. The degradation of cellulose involves an interplay between different cellulolytic enzymes. Hydrolysis starts with endoglucanases (EGs), which cut internal beta-1,4-gluc... | I want a protein that releases cellobiose from the non-reducing end of cellulose chains. |
A0A026W182 | FUNCTION: Odorant coreceptor which complexes with conventional odorant receptors (ORs) to form odorant-sensing units, providing sensitive and prolonged odorant signaling and calcium permeability (By similarity). Obligate coreceptor of all odorant receptors (By similarity). Orco is a universal and integral part of the f... | Design a protein that acts as an odorant coreceptor to form functional olfactory sensing units. |
A0A044RE18 | FUNCTION: Serine endoprotease which cleaves substrates at the RX(K/R)R consensus motif. {ECO:0000269|PubMed:12855702}. | Suggest a protein that is a serine endoprotease cleaving substrates at the RX(K/R)R motif. |
A0A059TC02 | FUNCTION: Involved in the latter stages of lignin biosynthesis (PubMed:24985707). Catalyzes one of the last steps of monolignol biosynthesis, the conversion of cinnamoyl-CoAs into their corresponding cinnamaldehydes (PubMed:24985707, PubMed:25217505). Mediates the conversion of feruloyl CoA to coniferylaldehyde (PubMed... | Generate a protein that converts cinnamoyl-CoA esters into cinnamaldehydes during lignin biosynthesis. |
A0A059WI14 | FUNCTION: Nonheme iron-dependent dioxygenase that can break carbon-arsenic bonds, playing a role in the detoxification of environmental organoarsenical compounds. Catalyzes the oxygen-dependent demethylation of highly toxic methylarsonous acid (MAs(III)) to arsenite, which can then be exported out of the cell. Can also... | Provide a protein that breaks carbon-arsenic bonds to detoxify methylated organoarsenical compounds. |
A0A060A682 | FUNCTION: During fertilization, required for the formation of intercellular membrane pores and subsequent exchange of gametic pronuclei between cells. Probably initiates the formation of intercellular membrane pores by inserting part of its extracellular domain into the cell membrane of the adjoining cell in the mating... | I would like a protein that forms intercellular membrane pores enabling gametic pronuclei exchange during fertilization. |
A0A061ACU2 | FUNCTION: Pore-forming subunit of a mechanosensitive non-specific cation channel (By similarity). Generates currents characterized by a linear current-voltage relationship (By similarity). Plays a role in reproduction by positively regulating inter-tissue signaling to promote oocyte maturation, ovulation and fertilizat... | I need a protein that forms the pore-forming subunit of a mechanosensitive non-specific cation channel. |
A0A061I403 | FUNCTION: Protein that can both mediate the addition of adenosine 5'-monophosphate (AMP) to specific residues of target proteins (AMPylation), and the removal of the same modification from target proteins (de-AMPylation), depending on the context (PubMed:27918543). The side chain of Glu-231 determines which of the two ... | Find me a protein that both adds and removes AMP modifications on target proteins to regulate the unfolded protein response. |
A0A067CMC7 | FUNCTION: Effector involved in the disease saprolegniosis in salmonids and other freshwater fish, resulting in considerable economic losses in aquaculture (PubMed:29904064). Within the host fish cells, Htp3 is released from vesicles into host cytosol where it degrades nucleic acids (PubMed:29904064). {ECO:0000269|PubMe... | I am looking for a protein that is released into host cells and degrades nucleic acids as a pathogen effector. |
A0A067XGX8 | FUNCTION: Involved in the production of volatile organic compounds (VOCs) (PubMed:24815009). Catalyzes an aldol-like condensation reaction between phosphoenolpyruvate (PEP) and D-erythrose 4-phosphate (E4P) to generate 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAH7P) and inorganic phosphate (By similarity). {ECO:000... | Give me a protein that condenses phosphoenolpyruvate and D-erythrose-4-phosphate to produce DAH7P. |
A0A067XH53 | FUNCTION: Involved in the production of volatile organic compounds (VOCs), including floral volatile benzenoids and phenylpropanoids (FVBP), in flowers of fragrant cultivars (e.g. cv. Mitchell and cv. V26), scent attracting pollinators (e.g. the night-active hawkmoth pollinator Manduca sexta) (PubMed:24815009). Catalyz... | I want a protein that condenses PEP and erythrose-4-phosphate to DAH7P during floral volatile compound biosynthesis. |
A0A067XR63 | FUNCTION: Catalyzes xyloglucan endotransglycosylation (XET). Cleaves and religates xyloglucan polymers. Does not catalyze xyloglucan endohydrolysis (XEH). Probably involved in cell wall assembly and synthesis in fast growing tissues and in the maintenance of firmness in mature fruits. {ECO:0000269|PubMed:27242828}. | Design a protein that cleaves and religates xyloglucan polymers during cell wall assembly. |
A0A067XRK9 | FUNCTION: Catalyzes xyloglucan endotransglycosylation (XET). Cleaves and religates xyloglucan polymers. Does not catalyze xyloglucan endohydrolysis (XEH). Probably involved in cell wall restructuring during postharvest fruit softening. {ECO:0000269|PubMed:27242828}. | Suggest a protein that remodels xyloglucan polymers in the cell wall during postharvest fruit softening. |
A0A067YMX8 | FUNCTION: Catalyzes xyloglucan endotransglycosylation (XET). Cleaves and religates xyloglucan polymers. Does not catalyze xyloglucan endohydrolysis (XEH). Overexpression in Arabidopsis transgenic plants causes accelerated dark-induced leaf senescence and higher lipid peroxidation of the leaf cells. Overexpression in tr... | Generate a protein that performs xyloglucan endotransglycosylation and promotes fruit ripening and softening. |
A0A068B6Q6 | FUNCTION: Alpha-conotoxins bind to the nicotinic acetylcholine receptors (nAChR) and inhibit them. This toxin inhibits mammalian alpha-3-beta-2/CHRNA3-CHRNB2 nAChR (IC(50)=9.4 nM (rat), IC(50)=8.8 nM (human)), as well as the subunit chimera alpha-6/alpha-3-beta-2-beta-3 nAChR (CHRNA6/CHRNA3-CHRNB2-CHRNB3)(IC(50)=2.1 nM... | Provide a protein that binds and inhibits nicotinic acetylcholine receptors with nanomolar potency. |
A0A068CNX1 | FUNCTION: Involved in the biosynthesis of vanillin and derivative natural products (PubMed:24941968). Catalyzes the double carbon bond cleavage of ferulic acid to vanillin and of respective glucosides (PubMed:24941968). {ECO:0000269|PubMed:24941968}. | I would like a protein that converts ferulic acid to vanillin via double carbon bond cleavage. |
A0A068J840 | FUNCTION: Component of the dammarane-type triterpene saponins (e.g. ginsenosides or panaxosides) biosynthetic pathway (PubMed:26032089, PubMed:29378087). Glycosyltransferase that catalyzes the biosynthesis of ginsenoside F1 from protopanaxatriol (PPT) (PubMed:26032089). Triggers C20-OH glycosylation of ginsenoside Rg3 ... | I need a protein that glycosylates ginsenoside precursors in the dammarane-type triterpene saponin pathway. |
A0A068Q5Q5 | FUNCTION: Functions as a receptor binding protein (RBP) and mediates the attachment to the host capsular exopolysaccharides (PubMed:35130876). Displays a lyase activity that specifically degrades the K1-type polysaccharides of Klebsiella pneumoniae capsule (PubMed:25001459, PubMed:35130876). {ECO:0000269|PubMed:2500145... | Find me a protein that binds bacterial capsular exopolysaccharides and degrades them via lyase activity. |
A0A072ULZ1 | FUNCTION: Phytoglobin that regulates the fine tuning of nitric oxide (NO) concentration in the cytosol in response to sudden changes in O(2) availability, and performs both symbiotic and nonsymbiotic functions (PubMed:33329665). Exhibits NO dioxygenase activity in the presence of O(2) but nitrite reductase (NiR) activi... | I am looking for a protein that scavenges nitric oxide under aerobic conditions and reduces nitrite under hypoxia. |
A0A072UR65 | FUNCTION: Possesses chitinase activity in vitro toward glycol chitin, carboxymethyl-chitin, colloidal chitin, and the chitin oligosaccharides (N-acetylglucosamine) (GlcNAc)6 and (GlcNAc)5 (PubMed:27383628). Hydrolyzes (GlcNAc)6 into (GlcNAc)4 and (GlcNAc)2, or two (GlcNAc)3 molecules (PubMed:27383628). Has the capacity... | Give me a protein that hydrolyzes chitin oligosaccharides and inhibits fungal hyphal growth. |
A0A072VDF2 | FUNCTION: Involved in the latter stages of lignin biosynthesis (PubMed:20876124). Catalyzes one of the last steps of monolignol biosynthesis, the conversion of cinnamoyl-CoAs into their corresponding cinnamaldehydes (PubMed:20876124). Mediates the conversion of feruloyl-CoA to coniferylaldehyde (PubMed:20876124). Also ... | I want a protein that converts feruloyl-CoA to coniferylaldehyde during monolignol biosynthesis. |
A0A072VIM5 | FUNCTION: May act as a substrate-specific adapter of an E3 ubiquitin-protein ligase complex (CUL3-RBX1-BTB) which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity). Transcriptional co-regulator involved in the promotion of leaf and floral meristem fate and determinacy... | Design a protein that serves as an E3 ubiquitin ligase adapter to promote symbiotic root nodule development. |
A0A075BSX9 | FUNCTION: Involved in the degradation of L-nicotine (PubMed:25002425). Catalyzes the oxidation of (S)-6-hydroxynicotine (6-hydroxy-L-nicotine) to 6-hydroxypseudooxynicotine (PubMed:25002425). Oxidation of the pyrrolidine ring of (S)-6-hydroxynicotine leads to the formation of the optically inactive 6-hydroxy-N-methylmy... | Suggest a protein that oxidizes (S)-6-hydroxynicotine during the nicotine degradation pathway. |
A0A075D5I4 | FUNCTION: S-adenosyl-L-methionine-dependent N-methyltransferase involved in the biosynthesis of biologically active monoterpenoid indole alkaloids (MIAs) natural products including vindoline (PubMed:26848097). Catalyzes the conversion of picrinine to N-methylpicrinine (ervincine) (PubMed:26848097). Also accepts, with l... | Generate a protein that N-methylates alkaloid precursors using SAM during monoterpenoid indole alkaloid biosynthesis. |
A0A075D657 | FUNCTION: S-adenosyl-L-methionine-dependent N-methyltransferase involved in the biosynthesis of biologically active monoterpenoid indole alkaloids (MIAs) natural products including vindoline (PubMed:26848097). Catalyzes the conversion of picrinine to N-methylpicrinine (ervincine) (PubMed:26848097). Also accepts, with l... | Provide a protein that methylates picrinine to produce N-methylpicrinine in alkaloid biosynthesis. |
A0A075F7E9 | FUNCTION: Involved in innate immunity. Required for the expression of defense-related genes PR1A, LOX2 and CHS1 upon biotic stresses. Required for basal resistance to the fungal blast (M.grisea), bacterial blight (O.oryzae pv. oryzae, Xoo) and the herbivorous insect brown planthopper (N.lugens, BPH). May be involved in... | I would like a protein that activates defense-related gene expression to confer resistance to fungal and bacterial pathogens. |
A0A075F932 | FUNCTION: Calcium sensor that participates in triggering neurotransmitter release at the synapse (By similarity). May have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse. It binds acidic phospholipids with a specificity that requires the presence... | I need a protein that senses calcium to trigger neurotransmitter release at the synapse. |
A0A075FBG7 | FUNCTION: Involved in the biosynthesis of labdane-type diterpenoid including marrubiin and other labdane-related furanoid diterpenoids with potential applications as anti-diabetics, analgesics or vasorelaxants (Probable). Terpene synthase the catalyzes the conversion of peregrinol diphosphate to 9,13(R)-epoxy-labd-14-e... | Find me a protein that converts copalyl diphosphate to miltiradiene during labdane diterpenoid biosynthesis. |
A0A075QQ08 | FUNCTION: Component of the protein complex eIF4F, which is involved in the recognition of the mRNA cap, ATP-dependent unwinding of 5'-terminal secondary structure and recruitment of mRNA to the ribosome (PubMed:15988567). Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiat... | I am looking for a protein that recognizes the 5' mRNA cap and unwinds secondary structures to initiate translation. |
A0A075TJ05 | FUNCTION: Carboxypeptidase that catalyzes the release of a C-terminal amino acid with specific catalytic activity for aromatic amino acids such as phenylalanine (PubMed:24947135, PubMed:33647354). Is able to degrade ochratoxin A, one of the five major mycotoxins most harmful to humans and animals that is produced by As... | Give me a protein that degrades ochratoxin A by releasing C-terminal aromatic amino acids. |
A0A075TMP8 | FUNCTION: Cytochrome P450 monooxygenase; part of the gene cluster that mediates the biosynthesis of patulin, an acetate-derived tetraketide mycotoxin produced by several fungal species that shows antimicrobial properties against several bacteria (PubMed:25625822, PubMed:30100914, PubMed:30680886). PatI catalyzes the co... | I want a protein that is a cytochrome P450 converting m-hydroxybenzyl alcohol to gentisyl alcohol. |
A0A075TR33 | FUNCTION: FAD-linked oxidoreductase; part of the gene cluster that mediates the biosynthesis of patulin, an acetate-derived tetraketide mycotoxin produced by several fungal species that shows antimicrobial properties against several bacteria (PubMed:25625822, PubMed:30100914, PubMed:30680886). PatO acts with patJ in th... | Design a protein that is a FAD-linked oxidoreductase converting gentisyl alcohol to isoepoxydon. |
A0A075TRC0 | FUNCTION: 6-methylsalicylic acid synthase; part of the gene cluster that mediates the biosynthesis of patulin, an acetate-derived tetraketide mycotoxin produced by several fungal species that shows antimicrobial properties against several bacteria (PubMed:25625822, PubMed:30100914, PubMed:30680886, PubMed:35339702). Pa... | Suggest a protein that synthesizes 6-methylsalicylic acid from acetate and malonate via polyketide condensation. |
A0A075TRK9 | FUNCTION: Patulin synthase; part of the gene cluster that mediates the biosynthesis of patulin, an acetate-derived tetraketide mycotoxin produced by several fungal species that shows antimicrobial properties against several bacteria (PubMed:25625822, PubMed:30100914, PubMed:30680886). PatE catalyzes the last step of th... | Generate a protein that converts E-ascladiol to patulin as the final step in mycotoxin biosynthesis. |
A0A075TRL5 | FUNCTION: Cytochrome P450 monooxygenase; part of the gene cluster that mediates the biosynthesis of patulin, an acetate-derived tetraketide mycotoxin produced by several fungal species that shows antimicrobial properties against several bacteria (PubMed:25625822, PubMed:30100914, PubMed:30680886). PatH catalyzes the co... | Provide a protein that hydroxylates m-cresol to m-hydroxybenzyl alcohol via cytochrome P450 activity. |
A0A076FFM5 | FUNCTION: Rieske-type, PAO-family oxygenase involved in the biosynthesis of polymethoxylated flavonoids natural products such as nevadensin and salvigenin, aroma compounds which contribute to the flavor of sweet basil, and exhibit pharmacological activities such as anti-allergic, anti-oxidant, antibacterial, anti-proli... | I would like a protein that hydroxylates salvigenin at position 8 during polymethoxylated flavonoid biosynthesis. |
A0A078CGE6 | FUNCTION: Serine/threonine-protein kinase involved in the spatial and temporal control system organizing cortical activities in mitotic and postmitotic cells (PubMed:11489177). Required for the normal functioning of the plasma membrane in developing pollen. Involved in the regulation of cell expansion and embryo develo... | I need a protein that is a serine/threonine kinase organizing cortical activities in dividing and postmitotic cells. |
A0A080WMA9 | FUNCTION: Catalyzes the NADPH-dependent formation of L-aspartate 4-semialdehyde (L-ASA) by the reductive dephosphorylation of 4-phospho-L-aspartate (PubMed:26869335). Mediates the second step in the biosynthesis of amino acids that derive from aspartate (the aspartate family of amino acids), including methioinine and t... | Find me a protein that converts 4-phospho-L-aspartate to L-aspartate semialdehyde via NADPH-dependent reduction. |
A0A087WPF7 | FUNCTION: Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitinatio... | I am looking for a protein that monoubiquitinates histone H2A to repress transcription and promotes neurite elongation. |
A0A087X1C5 | FUNCTION: May be responsible for the metabolism of many drugs and environmental chemicals that it oxidizes. It may be involved in the metabolism of codeine to morphine (PubMed:15051713). However, another study could not confirm it (PubMed:18838503). {ECO:0000269|PubMed:15051713, ECO:0000269|PubMed:18838503}. | Give me a protein that oxidizes drugs and environmental chemicals including the conversion of codeine to morphine. |
A0A088MIT0 | FUNCTION: [[Val1,Thr6]-bradykinyl-Ser,Pro,Ala]: May produce in vitro relaxation of rat arterial smooth muscle and constriction of intestinal smooth muscle. May target bradykinin receptors (BDKRB). {ECO:0000250|UniProtKB:P84899}.; FUNCTION: [Bradykinin]: May produce in vitro relaxation of rat arterial smooth muscle and ... | I want a protein that relaxes arterial smooth muscle and constricts intestinal smooth muscle via bradykinin receptors. |
A0A088MLT8 | FUNCTION: May play a role in action potential conduction in myelinated cells through the organization of molecular complexes at nodes of Ranvier and axon initial segments (PubMed:25950943, PubMed:25953347, PubMed:27979964). May also play a role in axon outgrowth and guidance (PubMed:25953347). {ECO:0000269|PubMed:25950... | Design a protein that organizes molecular complexes at nodes of Ranvier to support action potential conduction. |
A0A089QRB9 | FUNCTION: Polyketide synthase involved in the biosynthesis of methyl-branched fatty acids such as mycolipanoic, mycolipenic (phthienoic) and mycolipodienoic acids required for the synthesis of a major class of polyacylated trehaloses. Catalyzes the elongation of CoA esters of long-chain fatty acids by incorporation of ... | Suggest a protein that elongates fatty acyl chains by incorporating methylmalonyl residues to produce methyl-branched fatty acids. |
A0A095AMW7 | FUNCTION: Involved in the malolactic fermentation (MLF) of wine, which results in a natural decrease in acidity and favorable changes in wine flavors. Catalyzes the decarboxylation of L-malate to L-lactate. {ECO:0000269|PubMed:16345941}. | Generate a protein that decarboxylates L-malate to L-lactate during malolactic fermentation. |
A0A095C325 | FUNCTION: Pleiotropic ABC efflux transporter that confers resistance to structurally and functionally unrelated compounds including azoles such as fluconazole (FLC), itraconazole (ITC), posaconazole (POS), nocodazole and voriconazole (VRC). {ECO:0000269|PubMed:25630649, ECO:0000269|PubMed:29378705}. | Provide a protein that is an ABC efflux transporter conferring broad resistance to azole antifungal drugs. |
A0A095C6S0 | FUNCTION: Catalyzes the oxidative deamination of D-amino acids with broad substrate specificity (PubMed:26132227). Enables the organism to utilize D-amino acids as a source of nutrients (PubMed:26132227). Enables the organism to utilize D-alanine, D-cysteine, D-histidine, D-leucine, D-methionine, D-phenylalanine, D-pro... | I would like a protein that oxidatively deaminates D-amino acids with broad specificity to enable their use as nitrogen sources. |
A0A096LP01 | FUNCTION: May play a role in cell viability. {ECO:0000269|PubMed:34445188}. | I need a protein that plays a role in maintaining cell viability. |
A0A096MJN4 | FUNCTION: Filament-forming cytoskeletal GTPase. Pro-apoptotic protein involved in LGR5-positive intestinal stem cell and Paneth cell expansion in the intestines, via its interaction with XIAP (By similarity). May also play a role in the regulation of cell fate in the intestine (By similarity). Positive regulator of apo... | Find me a protein that is a filament-forming GTPase involved in apoptosis regulation and sperm flagellum integrity. |
A0A096MJY4 | FUNCTION: Transcription activator which binds specifically to the MEF2 element present in the regulatory regions of many muscle-specific genes (PubMed:15862299). Controls cardiac morphogenesis and myogenesis, and is also involved in vascular development. Enhances transcriptional activation mediated by SOX18. Plays an e... | I am looking for a protein that binds MEF2 promoter elements to activate muscle-specific genes and control cardiac morphogenesis. |
A0A096MK47 | FUNCTION: Required for myoblast differentiation into myotubes, possibly acting as a transcriptional regulator of the myogenic program (By similarity). Required for cardiac adaptation to stress through integrated regulation of the AKT/mTOR pathways and FOXO1. Regulates cardiac homeostasis and plays a role in the protect... | Give me a protein that regulates AKT/mTOR signaling to drive myoblast differentiation and protect against cardiac hypertrophy. |
A0A096P8D3 | FUNCTION: Performs an essential role in the oxidative function of the tricarboxylic acid cycle and respiration (Probable). Catalyzes the decarboxylation of isocitrate to produce 2-oxoglutarate and generate NADH to provide electrons for energy production (Probable). {ECO:0000305|PubMed:25724193}. | I want a protein that decarboxylates isocitrate to produce 2-oxoglutarate and NADH in the TCA cycle. |
A0A097PTA8 | FUNCTION: Antimicrobial peptide that acts against Gram-positive bacteria (Listeria spp., Enterococcus spp., B.subtilis, B.anthracis, P.aeruginosa) (PubMed:25342741, PubMed:28825809). Is not active against Gram-negative bacteria (PubMed:25342741). It selectively inhibits peptidoglycan biosynthesis through complex format... | Design a protein that inhibits peptidoglycan biosynthesis in Gram-positive bacteria by binding and sequestering lipid II. |
A0A098D6U0 | FUNCTION: Non-reducing polyketide synthase; part of the gene cluster that mediates the biosynthesis of zearalenone (ZEA), a nonsteroid estrogen that is a contaminant of cereal grains and causes estrogenic disorders in humans and animals (PubMed:16262793, PubMed:16517624, PubMed:18427109). The ZEA backbone is synthesize... | Suggest a protein that is a non-reducing polyketide synthase forming the resorcylate core and macrolactone ring of zearalenone. |
A0A0A0LLY1 | FUNCTION: Possibly has a role in RNA transcription or processing during stress (By similarity). Binds sequence non-specifically to RNAs and DNAs (By similarity). Mediates cell-to-cell trafficking of RNA interference (RNAi) signals (small RNAs (sRNA), e.g. small interfering RNA (siRNA) and microRNA (miRNA)) which regula... | Generate a protein that transports small RNAs including siRNA and miRNA between cells to spread gene silencing signals. |
A0A0A1C3I2 | FUNCTION: Catalyzes the synthesis of mevalonate, the specific precursor of all isoprenoid compounds present in plants (By similarity). Component of the triterpene saponins (e.g. ginsenosides or panaxosides) and phytosterols biosynthetic pathways (PubMed:24569845, PubMed:29378087). Promotes triterpenes accumulation in r... | Provide a protein that synthesizes mevalonate as the universal precursor for plant isoprenoid biosynthesis. |
A0A0A1C930 | FUNCTION: Catalyzes the synthesis of mevalonate, the specific precursor of all isoprenoid compounds present in plants (By similarity). Component of the triterpene saponins (e.g. ginsenosides or panaxosides) and phytosterols biosynthetic pathways (PubMed:24569845, PubMed:29378087). {ECO:0000250|UniProtKB:P14891, ECO:000... | I would like a protein that produces mevalonate as the precursor for isoprenoids and triterpene saponins. |
A0A0A1H8I4 | FUNCTION: Involved in assimilation of trans-aconitic acid. Preference for cis-aconitic acid is 14-fold higher than for trans-aconitic acid. Not active on intermediates of tricarboxylic acid (TCA) cycle including citric acid, succinic acid, fumaric acid, and 2-oxoglutaric acid or on other dicarboxilic acids including it... | I need a protein that assimilates trans-aconitic acid with a preference for the cis isomer. |
A0A0A1HA03 | FUNCTION: UDP-glucose-dependent glucosyltransferase catalyzing the C-glucosylation of 2-hydroxyflavanones (2-hydroxynaringenin, 2-hydroxyeriodictyol and 2-hydroxypinocembrin) and phloretin (PubMed:25142187). No activity with flavanones, flavones or flavonols (PubMed:25142187). Exhibits C-glycosylation activity toward 2... | Find me a protein that C-glucosylates 2-hydroxyflavanones and phloretin using UDP-glucose as the sugar donor. |
A0A0A1I6E7 | FUNCTION: Has antimicrobial activity against the Gram-positive bacteria S.aureus (MIC=8 uM) and the yeast C.albicans (MIC=16 uM). Causes hemolysis on horse erythrocytes (64 uM for 100% hemolysis). Minimum bactericidal concentrations have also been tested against S.aureus and is four-fold higher (MBC=32 uM). {ECO:000026... | I am looking for a protein that kills Gram-positive bacteria and fungi while causing hemolysis of red blood cells. |
A0A0A1I6N9 | FUNCTION: Has antimicrobial activity against the Gram-positive bacteria S.aureus (MIC=8 uM) and the yeast C.albicans (MIC=16 uM). Causes hemolysis on horse erythrocytes (64 uM for 100% hemolysis). Minimum bactericidal concentrations have also been tested against S.aureus and is four-fold higher (MBC=32 uM). {ECO:000026... | Give me a protein that has antimicrobial activity against S. aureus and C. albicans with hemolytic side effects. |
A0A0A6ZFY4 | FUNCTION: Component of the dammarane-type triterpene saponins (e.g. PPD-type ginsenosides or panaxosides) biosynthetic pathway (PubMed:25320211, PubMed:25769286, PubMed:27746309, PubMed:29378087). Glycosyltransferase that catalyzes the conversion of ginsenoside Rh2 to ginsenoside Rg3 (PubMed:25320211, PubMed:25769286, ... | I want a protein that glycosylates ginsenoside Rh2 to produce ginsenoside Rg3 in the triterpene saponin pathway. |
A0A0A7EPL0 | FUNCTION: Together with MOM1 and PIAL2, regulates transcriptional gene silencing (TGS) independently of changes in DNA methylation (PubMed:27113777). E4-type SUMO ligase that promotes SUMO chain formation in a SCE1-dependent manner and thus contributes to a pathway for proteolytic removal of sumoylation substrates (Pub... | Design a protein that acts as an E4 SUMO ligase promoting SUMO chain formation for targeted protein degradation. |
A0A0A7EQR3 | FUNCTION: Glucuronoyl esterase which may play a significant role in biomass degradation, as it is considered to disconnect hemicellulose from lignin through the hydrolysis of the ester bond between 4-O-methyl-D-glucuronic acid residues of glucuronoxylans and aromatic alcohols of lignin (PubMed:25425346, PubMed:26712478... | Suggest a protein that hydrolyzes ester bonds between glucuronoxylan and lignin aromatic alcohols to enable biomass degradation. |
A0A0A7GEY4 | FUNCTION: Catalyzes the addition of 3 molecules of isopentenyl diphosphate (IPP) onto dimethylallyl diphosphate (DMAPP) to form geranylgeranyl pyrophosphate (GGPP). Catalyzes the synthesis of geranylgeranyl pyrophosphate as a major product and of farnesyl pyrophosphate in smaller amounts. {ECO:0000269|PubMed:30062607}. | Generate a protein that adds three isopentenyl diphosphate units to DMAPP to produce geranylgeranyl pyrophosphate. |
A0A0A7HFE1 | FUNCTION: CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target ... | Provide a protein that synthesizes cyclic oligoadenylates as second messengers to activate antiviral immunity. |
A0A0A7HFE6 | FUNCTION: CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target ... | I would like a protein that is a single-strand endoribonuclease activated 1000-fold by cyclic hexaadenylate. |
A0A0A7HIF0 | FUNCTION: CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target ... | I need a protein that cleaves single-stranded RNA at 6-nucleotide intervals as part of CRISPR immune surveillance. |
A0A0A7HIX6 | FUNCTION: CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target ... | Find me a protein that is a single-strand endoribonuclease cleaving at GA/AA dinucleotides when activated by cyclic oligoadenylate. |
A0A0A8IDB7 | FUNCTION: Pyrroloquinoline quinone (PPQ)-dependent oxidoreductase that catalyzes the oxidation of various sugars including L-galactose, L-gulose, D-talose, D-arabinose, D-lyxose, L-fucose and D-glucosone (PubMed:25121592, PubMed:25679509, PubMed:27338639). Shows significant activity toward the reverse-chair conformatio... | I am looking for a protein that is a PQQ-dependent oxidoreductase oxidizing rare sugars like L-galactose and D-talose. |
A0A0B0QJR1 | FUNCTION: Toxic component of a type VII toxin-antitoxin (TA) system. Upon cloning in E.coli inhibits cell growth for several hours; eventually cells recover and start growing. Cleaves the last 4 nucleotides from the tRNA acceptor stem (shown in vitro with E.coli tRNA-Glu(UUC)); only cleaves intact tRNA. Has no activity... | Give me a protein that cleaves the acceptor stem of intact tRNAs as a bacterial toxin in a toxin-antitoxin system. |
A0A0B4J1F4 | FUNCTION: Functions as an adapter recruiting ubiquitin-protein ligases to their specific substrates (PubMed:27462458). Plays a role in endocytosis of activated G protein-coupled receptors (GPCRs) (By similarity). Through an ubiquitination-dependent mechanism also plays a role in the incorporation of SLC11A2 into extrac... | I want a protein that recruits E3 ubiquitin ligases to substrates to mediate endocytosis of activated G protein-coupled receptors. |
A0A0B4J1G0 | FUNCTION: Receptor for the invariable Fc fragment of immunoglobulin gamma (IgG) (PubMed:16039578). Binds with intermediate affinity to both IgG2a and IgG2b (PubMed:16039578, PubMed:17558411, PubMed:19795417). Can bind to IgG2a and IgG2b monomers (PubMed:18949059). Does not display binding to IgG1 or IgG3 (PubMed:160395... | Design a protein that is an Fc receptor for IgG mediating antibody-dependent cellular cytotoxicity and antigen presentation. |
A0A0B4J1N3 | FUNCTION: Highly cationic protein that has multiple functions. Acts as a chemotactic factor that mediates lymphocytes recruitment to epithelia through binding and activation of the G-protein coupled receptor GPR15 (PubMed:28900043, PubMed:28936214). May be a tumor suppressor; together with SUSD2 has a growth inhibitory... | Suggest a protein that recruits lymphocytes to epithelia via GPR15 and has antimicrobial activity against Gram-positive bacteria. |
A0A0B4J2F0 | FUNCTION: Plays a role in regulation of the unfolded protein response triggered by endoplasmic reticulum (ER) stress resulting from the presence of unfolded proteins in the ER lumen. {ECO:0000269|PubMed:31653868}. | Generate a protein that regulates the unfolded protein response triggered by endoplasmic reticulum stress. |
A0A0B4K692 | FUNCTION: Metalloendoprotease which cleaves peptides such as tachykinin peptide TK-2 at the amino side of hydrophobic residues (PubMed:15554877, PubMed:17157960). Functions in female fertility, embryogenesis and memory formation (PubMed:24395329, PubMed:27629706). Required in females for normal patterns of egg laying, ... | Provide a protein that is a metalloendoprotease cleaving neuropeptides at hydrophobic residues, with roles in memory and fertility. |
A0A0B4K7J2 | FUNCTION: E3 SUMO-protein ligase (By similarity). Component of the nuclear pore complex (NPC), a complex required for trafficking across the nuclear envelope (PubMed:17682050). Required for nuclear import of nuclear localization signal (NLS)-containing proteins in an importin alpha/importin beta-dependent manner, but a... | I would like a protein that is both an E3 SUMO ligase and a nuclear pore component regulating nuclear import and piRNA biogenesis. |
A0A0B4K7K9 | FUNCTION: Structural component of the presynaptic active zone cytomatrix (T-bar) electron-dense structures involved in assembly, structural integrity, organization and function of presynaptic active zones (PubMed:16543132, PubMed:16614170, PubMed:19596851, PubMed:23960145, PubMed:25130366). Acts as a tether, binding an... | I need a protein that scaffolds the presynaptic active zone and tethers synaptic vesicles near calcium channels for fast release. |
A0A0B4KEE4 | FUNCTION: Component of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex involved in the connection between the nuclear lamina and the cytoskeleton (By similarity). Is required to nuclear migration in eye and to anchor klar in the nuclear membrane (PubMed:18820457). {ECO:0000250|UniProtKB:O94901, ECO:0000269... | Find me a protein that bridges the nuclear lamina to the cytoskeleton as part of the LINC complex. |
A0A0B4KGY6 | FUNCTION: Functions to regulate alternative splicing in neurons by binding pre-mRNA in a sequence-specific manner to activate exon inclusion (By similarity). Plays a role in long-term memory formation by processing the unspliced Orb2-isoform A (Orb2A) mRNA and thereby controlling Orb2A protein abundance (PubMed:2852575... | I am looking for a protein that regulates alternative splicing in neurons to control long-term memory formation. |
A0A0B4LFY9 | FUNCTION: Facilitator of innate immune signaling that binds cyclic dinucleotides produced in response to infection by bacteria and/or viruses, and promotes the activation of the NF-kappa-B transcription factor Rel (Relish) (PubMed:29924997, PubMed:29934091, PubMed:30119996, PubMed:33262294, PubMed:34261127, PubMed:3426... | Give me a protein that binds cyclic dinucleotides produced during bacterial and viral infection to activate innate immunity. |
A0A0B4U9L8 | FUNCTION: Zinc metalloprotease that has fibrinogenolytic activity. Does not have hemorrhagic activity in rats. Cleaves insulin B chain at '38-Ala-|-Leu-39' and '40-Tyr-|-Leu-41' bonds. Hydrolyzes only partially and weakly isolated extracellular matrix (ECM) bovine fibronectin and basal membrane (BM) protein human colla... | I want a protein that is a zinc metalloprotease with fibrinogenolytic activity cleaving the fibrinogen alpha chain. |
A0A0B5A051 | FUNCTION: Involved in the biosynthesis of prenylated phenolics natural products which contribute to the bitter taste of beer and display broad biological activities (Probable). Catalyzes the first prenylation step in the beta-bitter acid pathway (PubMed:25564559). Uses dimethylallyl diphosphate (DMAPP) as the prenyl do... | Design a protein that catalyzes the first prenylation step in bitter acid biosynthesis using DMAPP as the prenyl donor. |
A0A0B5A886 | FUNCTION: [Glycoprotein N]: Structural component of the virion that interacts with glycoprotein C (By similarity). It shields the hydrophobic fusion loops of the glycoprotein C, preventing premature fusion (By similarity). The glycoprotein protrusions are arranged on an icosahedral lattice, with T=12 triangulation (By ... | Suggest a protein that is a viral glycoprotein shielding fusion loops and mediating virion attachment to host DC-SIGN. |
A0A0B5A8P4 | FUNCTION: This venom insulin, from a fish-hunting cone snail, facilitates prey capture by rapidly inducing hypoglycemic shock (PubMed:30747102). It is one of the smallest known insulin found in nature and lacks the C-terminal segment of the B chain that, in human insulin, mediates engagement of the insulin receptor (IN... | Generate a protein that is a minimized venom insulin activating the human insulin receptor to rapidly induce hypoglycemia. |
A0A0B5AC19 | FUNCTION: Sequesters host STAT2 into viral inclusion bodies (Probable) (PubMed:29886262). Impairs IFN-stimulated phosphorylation and nuclear translocation of host STAT2, thereby suppressing type-I IFN antiviral signaling (Probable) (PubMed:28680969, PubMed:29886262). Sequesters host TRIM25, RIGI, TBK1/IKK complex compo... | Provide a protein that sequesters STAT2 and TBK1 into viral inclusion bodies to suppress interferon antiviral signaling. |
A0A0B5AC95 | FUNCTION: This venom insulin, from a fish-hunting cone snail, facilitates prey capture by rapidly inducing hypoglycemic shock (PubMed:25605914, PubMed:27617429). It is one of the smallest known insulin found in nature and lacks the C-terminal segment of the B chain that, in human insulin, mediates engagement of the ins... | I would like a protein that is a potent venom insulin binding and activating the human insulin receptor at nanomolar concentrations. |
A0A0B5JC15 | FUNCTION: Endo-1,4-beta-xylanase involved in the hydrolysis of xylan, a major structural heterogeneous polysaccharide found in plant biomass representing the second most abundant polysaccharide in the biosphere, after cellulose (PubMed:25629035). Shows maximum activity on soluble wheat arabinoxylan (defined as 100%), m... | I need a protein that hydrolyzes beta-1,4-xylosidic linkages in arabinoxylan and birchwood xylan. |
A0A0B5L781 | FUNCTION: O-methyltransferase; part of the gene cluster that mediates the biosynthesis of mycophenolic acid (MPA), the first isolated antibiotic natural product in the world obtained from a culture of Penicillium brevicompactum in 1893 (PubMed:25630520, PubMed:31209052). MpaG' catalyzes the 5-O-methylation of three pre... | Find me a protein that performs 5-O-methylation of intermediates in mycophenolic acid biosynthesis. |
A0A0B5LB55 | FUNCTION: Type I acyl-CoA thioesterase; part of the gene cluster that mediates the biosynthesis of mycophenolic acid (MPA), the first isolated antibiotic natural product in the world obtained from a culture of Penicillium brevicompactum in 1893 (PubMed:31209052, PubMed:33843134). MpaH' acts as a peroxisomal acyl-CoA hy... | I am looking for a protein that is a peroxisomal acyl-CoA thioesterase releasing mycophenolic acid from its CoA thioester. |
A0A0B6CGH9 | FUNCTION: Oxoglutarate-dependent dioxygenase (2-ODD) acting as a flavonoid 7-O-demethylase involved in the biosynthesis of polymethoxylated flavonoids natural products such as nevadensin and salvigenin, aroma compounds which contribute to the flavor of sweet basil, and exhibit pharmacological activities such as anti-al... | Give me a protein that demethylates methoxylated flavones at the 7-O position via 2-oxoglutarate-dependent dioxygenase activity. |
A0A0B6VIJ5 | FUNCTION: UDP-glucose-dependent glucosyltransferase involved in C-glycosylflavone biosynthesis (PubMed:25479084, PubMed:31399929). Has a strict stereo selectivity and shows a preference for apigenin and luteolin as substrates, but could not recognize flavonols, anthocyanins and xanthones as glucosyl acceptors (PubMed:2... | I want a protein that C-glucosylates apigenin and luteolin using UDP-glucose in flavone glycoside biosynthesis. |
A0A0B7P3V8 | FUNCTION: Capsid protein (CA) is the structural component of the virus-like particle (VLP), forming the shell that encapsulates the retrotransposons dimeric RNA genome. {ECO:0000250}.; FUNCTION: The aspartyl protease (PR) mediates the proteolytic cleavages of the Gag and Gag-Pol polyproteins after assembly of the VLP. ... | Design a protein that forms the structural shell of a virus-like particle encapsulating retrotransposon RNA. |
A0A0B7P9G0 | FUNCTION: Probable metal transporter (By similarity). Acts downstream of PRL-1 and protects the nervous system against olfactory carbon dioxide stimulation (PubMed:31404830). {ECO:0000250|UniProtKB:Q3TWN3, ECO:0000269|PubMed:31404830}. | Suggest a protein that acts as a metal transporter protecting the nervous system from olfactory carbon dioxide stimulation. |
A0A0C1EH92 | FUNCTION: UDP-glycosyltransferase; part of the gene cluster that mediates the biosynthesis of stromemycin, a depside C-glucoside with two unsaturated C9 side chains belonging to aromatic polyketide glycosides (PubMed:38545685). Acts as the tailoring enzyme responsible for 3-C-glucosylation of bininalkenylresorcylic aci... | Generate a protein that performs 3-C-glucosylation of an aromatic polyketide intermediate in stromemycin biosynthesis. |
A0A0C3RR82 | FUNCTION: Fusion protein of the methyltransferase pgiM1 and 12 type II borosin core peptides; part of the gene cluster that mediates the biosynthesis of a type II borosin, a highly methylated cyclic peptide with potent biological activities (PubMed:31117659). Type II borosins derive from the C-terminus of the fusion pr... | Provide a protein that self-methylates its own backbone using SAM as a methyl donor to produce a cyclic modified peptide. |
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