It is conjectured by Kraeuter and Seifter that for n >= 5 the maximal permanent of a nonsingular n X n (+1,-1)-matrix is attained by a matrix with exactly n-1 -1's on the diagonal (compare
A087981).
This has been proved by Budrevich and Guterman. -
Sergei Shteiner, Jan 21 2020
The maximal possible value for the permanent of a singular n X n (+1,-1)-matrix is obviously n!.