Conjecture: Let a and b be relatively prime positive integers, and let c be any integer. For any positive integer n, there are primes p and q such that a*pi(p*n) - b*pi(q*n) = c.
In the case c = 0, this reduces to the conjecture in A260232.
For example, for a = 20, b = 19, c = 18 and n = 28, we have 20*pi(4549*28)-19*pi(4813*28) = 20*11931-19*12558 = 18 with 4549 and 4813 both prime.