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VOOZH | about |
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VOOZH | about |
*142962
Table of Contents
Alternative titles; symbols
HGNC Approved Gene Symbol: HOXB7
Cytogenetic location: 17q21.32 Genomic coordinates (GRCh38) : 17:48,607,232-48,611,017 (from NCBI)
Simeone et al. (1987) characterized 2 human cDNA clones, each containing a homeobox region. The corresponding genes, termed c1 (HOXB7) and c8 (HOXC6; 142972), were evaluated in different organs and body parts during human embryonic and fetal development. Differential expression suggested that the genes play a key role in a variety of developmental processes.
In mouse, Hoxb7 expression is confined to macrophages. Using RT-PCR, Lill et al. (1995) detected expression of HOXB7 in monocytes differentiated from HL60 cells by stimulation with vitamin D3. Overexpression of HOXB7 inhibited differentiation into granulocytes but not monocytes. However, RT-PCR analysis failed to detect HOXB7 expression in mature monocytes.
HOX proteins have a conserved DNA-binding homeodomain, a pentapeptide motif that mediates interactions with PBX proteins (e.g., PBX1; 176310), and an N-terminal octapeptide motif. Yaron et al. (2001) found that wildtype HOXB7 inhibited differentiation of a murine myelomonocytic cell line, 32D, but that mutations in any of the conserved regions blocked this inhibitory effect. Mutations in casein kinase phosphorylation sites, the glutamate-rich C terminus, or the N-terminal 14 residues of HOXB7 enhanced 32D differentiation.
As reviewed by Acampora et al. (1989), the HOXB7 (HOX2C) gene resides in the homeobox region-2 gene cluster on chromosome 17 between the HOXB8 (HOX2D; 142963) and HOXB6 (HOX2B; 142961) genes.
Acampora, D., D'Esposito, M., Faiella, A., Pannese, M., Migliaccio, E., Morelli, F., Stornaiuolo, A., Nigro, V., Simeone, A., Boncinelli, E. The human HOX gene family. Nucleic Acids Res. 17: 10385-10402, 1989. [PubMed: 2574852, related citations] [Full Text]
Lill, M. C., Fuller, J. F., Herzig, R., Crooks, G. M., Gasson, J. C. The role of the homeobox gene, HOX B7, in human myelomonocytic differentiation. Blood 85: 692-697, 1995. [PubMed: 7530503, related citations]
Simeone, A., Mavilio, F., Acampora, D., Giampaolo, A., Faiella, A., Zappavigna, V., D'Esposito, M., Pannese, M., Russo, G., Boncinelli, E., Peschle, C. Two human homeobox genes, c1 and c8: structure analysis and expression in embryonic development. Proc. Nat. Acad. Sci. 84: 4914-4918, 1987. [PubMed: 2885844, related citations] [Full Text]
Yaron, Y., McAdara, J. K., Lynch, M., Hughes, E., Gasson, J. C. Identification of novel functional regions important for the activity of HOXB7 in mammalian cells. J. Immun. 166: 5058-5067, 2001. [PubMed: 11290787, related citations] [Full Text]
Alternative titles; symbols
HGNC Approved Gene Symbol: HOXB7
Cytogenetic location: 17q21.32 Genomic coordinates (GRCh38) : 17:48,607,232-48,611,017 (from NCBI)
Simeone et al. (1987) characterized 2 human cDNA clones, each containing a homeobox region. The corresponding genes, termed c1 (HOXB7) and c8 (HOXC6; 142972), were evaluated in different organs and body parts during human embryonic and fetal development. Differential expression suggested that the genes play a key role in a variety of developmental processes.
In mouse, Hoxb7 expression is confined to macrophages. Using RT-PCR, Lill et al. (1995) detected expression of HOXB7 in monocytes differentiated from HL60 cells by stimulation with vitamin D3. Overexpression of HOXB7 inhibited differentiation into granulocytes but not monocytes. However, RT-PCR analysis failed to detect HOXB7 expression in mature monocytes.
HOX proteins have a conserved DNA-binding homeodomain, a pentapeptide motif that mediates interactions with PBX proteins (e.g., PBX1; 176310), and an N-terminal octapeptide motif. Yaron et al. (2001) found that wildtype HOXB7 inhibited differentiation of a murine myelomonocytic cell line, 32D, but that mutations in any of the conserved regions blocked this inhibitory effect. Mutations in casein kinase phosphorylation sites, the glutamate-rich C terminus, or the N-terminal 14 residues of HOXB7 enhanced 32D differentiation.
As reviewed by Acampora et al. (1989), the HOXB7 (HOX2C) gene resides in the homeobox region-2 gene cluster on chromosome 17 between the HOXB8 (HOX2D; 142963) and HOXB6 (HOX2B; 142961) genes.
Acampora, D., D'Esposito, M., Faiella, A., Pannese, M., Migliaccio, E., Morelli, F., Stornaiuolo, A., Nigro, V., Simeone, A., Boncinelli, E. The human HOX gene family. Nucleic Acids Res. 17: 10385-10402, 1989. [PubMed: 2574852] [Full Text: https://doi.org/10.1093/nar/17.24.10385]
Lill, M. C., Fuller, J. F., Herzig, R., Crooks, G. M., Gasson, J. C. The role of the homeobox gene, HOX B7, in human myelomonocytic differentiation. Blood 85: 692-697, 1995. [PubMed: 7530503]
Simeone, A., Mavilio, F., Acampora, D., Giampaolo, A., Faiella, A., Zappavigna, V., D'Esposito, M., Pannese, M., Russo, G., Boncinelli, E., Peschle, C. Two human homeobox genes, c1 and c8: structure analysis and expression in embryonic development. Proc. Nat. Acad. Sci. 84: 4914-4918, 1987. [PubMed: 2885844] [Full Text: https://doi.org/10.1073/pnas.84.14.4914]
Yaron, Y., McAdara, J. K., Lynch, M., Hughes, E., Gasson, J. C. Identification of novel functional regions important for the activity of HOXB7 in mammalian cells. J. Immun. 166: 5058-5067, 2001. [PubMed: 11290787] [Full Text: https://doi.org/10.4049/jimmunol.166.8.5058]
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