Animal products are critical to the nutrition,food security, livelihoods and resilience of hundreds of millions of people throughout the world. Livestock accounts for 40% of worldwide income from agriculture. Demand for animal products is set to continue increasing in the next three decades, as is their market price. If not carefully managed, a worldwide increase in the production of animal-derived products would increase pressure on natural resources (particularly water and land), significantly raising levels of dangerous greenhouse gas emissions and increasing the risk of people contracting zoonotic diseases. These realities are informing governments as they encourage the managed intensification of livestock production. They seek to do this in ways that take account of poorer people's contributions to the growth of rural economies. They look for ways to link together work on agricultural productivity, efficient food systems; infrastructure development; access to energy, water and affordable health care; and the sustenance of environmental services (including the mitigation of any further stimuli for changes in the global climate). Managed intensification of livestock production would also require long-term application of a One Health approach with its focus on mitigating health risks at the interfaces between animals and humans in different ecosystems. It will stimulate the joint working of multiple interests in pursuit of a common goal - ending hunger and malnutrition. The authors would like to see the One Health approach being incorporated within all nations' animal, environmental and public health policies and into the educational agendas of medical and veterinary undergraduate students. It must also be incorporated into preparedness, contingency planning, desk-top exercises and on-site simulations to get ready for the next mega disaster - no matter how improbable it might seem.