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URL: https://pubmed.ncbi.nlm.nih.gov/32726150/

⇱ Cardiac Endotheliitis and Multisystem Inflammatory Syndrome After COVID-19 - PubMed

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Conflict of interest statement

Authors have disclosed no conflicts of interest. Forms can be viewed at .

Figures

👁 Figure.
Figure.. Pathologic characteristics of cardiac endotheliitis and multisystem vasculitis. A.
Intact cardiac myocytes with a pattern of endotheliitis and vasculitis involving intervening small blood vessels and interstitial spaces, seen throughout extensive sampling of the heart (hematoxylin–eosin stain). B. Low-power image of a cardiac blood vessel with inflammatory cuffing (blue arrow) and no evidence of direct myocardial involvement. C. Myeloperoxidase immunostain highlighting a prominent neutrophilic component to the inflammation in small vessels (compare with D). D. Myeloperoxidase stain showing no significant endothelial inflammation in a coronary artery. E. CD4 immunostain showing CD4+ lymphocytes around small blood vessels in the epicardial fat, with large vessels relatively spared. F. CD8 immunostain showing reduced numbers of CD8+ compared with CD4+ lymphocytes. G. A similar neutrophilic vasculitis was seen in occasional portal triads of the liver, involving small arteries and veins with surrounding congestion and no direct inflammation of hepatocytes. Levels of aspartate aminotransferase and alanine aminotransferase became elevated just before death (Table).

References

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