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Current concepts in the diagnosis and management of cytokine release syndrome
Abstract: As immune-based therapies for cancer become potent, more effective, and more widely available, optimal management of their unique toxicities becomes increasingly important. Cytokine release syndrome (CRS) is a potentially life-threatening toxicity that has been observed following administration of natural and bispecific antibodies and, more recently, following adoptive T-cell therapies for cancer. CRS is associated with elevated circulating levels of several cytokines including interleukin (IL)-6 and interfero… Show more
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“…We observed that the majority of patients experienced CRS of any grade and a third experienced neurotoxicity of any grade. While previous studies have suggested a link between disease burden and the severity of these adverse events [82,83], this analysis did not find a significant difference based on disease burden. Despite the high incidence of serious adverse effects, the reported rate of treatment-related mortality was relatively low [84].…”
Section: Discussioncontrasting
confidence: 99%
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD).
Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD.
The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC).
Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
“…We observed that the majority of patients experienced CRS of any grade and a third experienced neurotoxicity of any grade. While previous studies have suggested a link between disease burden and the severity of these adverse events [82,83], this analysis did not find a significant difference based on disease burden. Despite the high incidence of serious adverse effects, the reported rate of treatment-related mortality was relatively low [84].…”
Section: Discussioncontrasting
confidence: 99%
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD).
Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD.
The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC).
Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
“…Although almost 50% of patients had no CRS, CAR‐T cell expansion (Figure S3) was still observed in 95% (19/20, one had no data) of patients, and the mean peak CAR‐T cell number in peripheral blood (PB) was similar to that in first CAR‐T ( p = .841; Figure S2(G) and Table S3). These results demonstrated that CRS and elevated serum cytokines induced by CAR‐T therapy were more correlated to the interaction between tumor cells and CAR‐T cells rather than CAR‐T cells themselves, also supported previous observations that the severity of CRS is positively associated with disease burden 17,18 …”
Section: Resultssupporting
confidence: 90%
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD).
Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD.
The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC).
Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
“…Therefore, LDH is a workable indicator of the progression of the infection. However, our result is matching with the result of other studies [ 68 ]. One of the interesting findings of our study was the positive correlation between LDH and neutrophils count.…”
Section: Discussionsupporting
confidence: 93%
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD).
Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD.
The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC).
Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
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