2017
|
Sign up to set email alerts
Cytokine storm and sepsis disease pathogenesis
Abstract: Infectious diseases are a leading cause of death worldwide. Sepsis is a severe clinical syndrome related to the host response to infection. The severity of infections is due to an activation cascade that will lead to an autoamplifying cytokine production: the cytokine storm. Cytokines are a broad category of relatively small proteins (<40 kDa) that are produced and released with the aim of cell signaling. Our understanding of the processes that trigger this tremendous amount of cytokine production has made dra… Show more
Search citation statements
Order By: Relevance
Paper Sections
Select...
921
275
172
37
Citation Types
15
1,005
0
35
Year Published
2017
20172026
2026Publication Types
Select...
1,148
82
76
41
Relationship
3
1,344
Authors
Journals
15
1,005
0
35
Order By: Relevance
“…The inability to measure bacterial and viral load before and after treatment with the Seraph ® filter is another limitation of the study, which would potentially add further value to our results. The association of endotoxemia with cytokine hyperproduction has been previously reported in some patients [45,46]. In this case, non-selective hemadsorption with CytoSorb ® or hemodiafiltration with oXiris ® and selective hemadsorption with polymyxin-bound membranes (Toraymyxin ® ) may be insufficient [47], which is in agreement with the results of our study.…”
Section: Discussionsupporting
confidence: 93%
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD).
Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD.
The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC).
Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
“…The inability to measure bacterial and viral load before and after treatment with the Seraph ® filter is another limitation of the study, which would potentially add further value to our results. The association of endotoxemia with cytokine hyperproduction has been previously reported in some patients [45,46]. In this case, non-selective hemadsorption with CytoSorb ® or hemodiafiltration with oXiris ® and selective hemadsorption with polymyxin-bound membranes (Toraymyxin ® ) may be insufficient [47], which is in agreement with the results of our study.…”
Section: Discussionsupporting
confidence: 93%
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD).
Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD.
The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC).
Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
“…Consistent with previous studies, we found that the serum cytokine levels of septic shock patients significantly increased and were characterized by cytokine storms ( 21 ). Moreover, studies have shown that elevated levels of IL-6, IL-8, and IL-10 are strongly associated with mortality ( 21 – 23 ), which is consistent with our findings. For many years, an excessive systemic inflammatory response was believed to contribute to sepsis-related death.…”
Section: Discussionsupporting
confidence: 92%
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD).
Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD.
The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC).
Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
“…In accordance with previous studies, our data also revealed that the concentration of IL‐10, an anti‐inflammatory cytokine, is positively correlated with the severity of COVID‐19 33 . The increased levels of IL‐10 in the plasma of COVID‐19 patients probably reflect a host response to prevent the harmful effect of the cytokine storm.…”
Section: Discussionsupporting
confidence: 91%
T cell counts and IL-6 concentration in blood of North African COVID-19 patients are two independent prognostic factors for severe disease and death
Belaid,
Lamara Mahammad,
Mihi
et al. 2021
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD).
Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD.
The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC).
Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
👁 scite logo
Scite is an AI-powered platform that helps researchers discover and evaluate scientific literature through Smart Citations, showing whether studies support or contradict a claim. Now part of Research Solutions, Scite has indexed 1.6B+ citations, partners with 30+ publishers, and serves 2M users worldwide.
Contact Info
customersupport@researchsolutions.com
10624 S. Eastern Ave., Ste. A-614
Henderson, NV 89052, USA
Resources
This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.
Copyright © 2026 Scite LLC. All rights reserved.
Made with 💙 for researchers
