2018
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Middle East respiratory syndrome coronavirus: risk factors and determinants of primary, household, and nosocomial transmission
Abstract: Middle East respiratory syndrome coronavirus (MERS-CoV) is a lethal zoonosis that causes death in 35·7% of cases. As of Feb 28, 2018, 2182 cases of MERS-CoV infection (with 779 deaths) in 27 countries were reported to WHO worldwide, with most being reported in Saudi Arabia (1807 cases with 705 deaths). MERS-CoV features prominently in the WHO blueprint list of priority pathogens that threaten global health security. Although primary transmission of MERS-CoV to human beings is linked to exposure to dromedary ca… Show more
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“…The association between COVID-19 and cardiovascular disease is rarely observed in other studies, which might be attributed to the speci c geographical environment of Heilongjiang Province. Studies on SARS-CoV and Middle East Respiratory Syndrome(MERS)-CoV infections demonstrated that the risk of exacerbation in patients increases markedly with age and the presence of underlying diseases [10][11][12], which was consistent with the conclusions of this study.…”
Section: Resultssupporting
confidence: 91%
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD).
Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD.
The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC).
Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
“…The association between COVID-19 and cardiovascular disease is rarely observed in other studies, which might be attributed to the speci c geographical environment of Heilongjiang Province. Studies on SARS-CoV and Middle East Respiratory Syndrome(MERS)-CoV infections demonstrated that the risk of exacerbation in patients increases markedly with age and the presence of underlying diseases [10][11][12], which was consistent with the conclusions of this study.…”
Section: Resultssupporting
confidence: 91%
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD).
Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD.
The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC).
Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
“…Our study do not appear to increase the risk of severe COVID-19 illness. These findings are similar to observations of prior coronavirus epidemics 27,28 (middle east respiratory syndrome and severe acute respiratory syndrome), as these viruses did not cause more severe disease in immunocompromised patients. 29 We observed that exposure to work contacts with COVID-19 symptoms, household contacts with COVID-19 symptoms, and working in a healthcare setting was associated with the report of symptoms consistent with COVID-19 illness.…”
Section: Principal Resultssupporting
confidence: 89%
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD).
Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD.
The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC).
Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
“…In addition, there was no statistically significant difference between mortality or the need for ICU admission between groups. These findings are consistent with previous research conducted on a similar group of patients [ 4 , 16 ]. In contrast to data from these few publications, Zhu and colleagues reported faster clinical deterioration and prolonged viral eradication in this specific group of patients, though their findings showed that the rate of unfavorable fatal outcomes was reduced due to suppression of hyperimmune response.…”
Section: Discussionsupporting
confidence: 94%
“…There was no difference between groups in terms of worse prognosis when we used the worst stage of each patient as a parameter for comparing the clinical deterioration and worse prognosis. Although our findings are consistent with those of D'Antiga [4] and Hui et al [16], Zhu et al [17] stated otherwise in a publication showing a higher rate of clinical deterioration in immunocompromised patients. This disparity in results could be attributed to the diversity in immunosuppressive regimens, which are tailored to the type and severity of the underlying disease.…”
Section: Discussionsupporting
confidence: 93%
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD).
Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD.
The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC).
Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
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