2019
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Saliva as a diagnostic specimen for testing respiratory virus by a point-of-care molecular assay: a diagnostic validity study
Abstract: Saliva specimen has high sensitivity and specificity in the detection of respiratory viruses by an automated multiplex Clinical Laboratory Improvement Amendments (CLIA)-waived point-of-care molecular assay when compared with that of NPA. The use of saliva also reduces the time and cost associated with specimen collection.
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“…However, the median Ct values of both gene targets in NPS were significantly earlier than those in saliva. This is compatible with our previous results from other respiratory viruses, in which nasopharyngeal specimens had higher viral load than that in saliva specimens [3,4].…”
Section: Discussionsupporting
confidence: 93%
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD).
Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD.
The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC).
Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
“…However, the median Ct values of both gene targets in NPS were significantly earlier than those in saliva. This is compatible with our previous results from other respiratory viruses, in which nasopharyngeal specimens had higher viral load than that in saliva specimens [3,4].…”
Section: Discussionsupporting
confidence: 93%
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD).
Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD.
The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC).
Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
“…It is important to note that testing of saliva caught 10 additional COVID-19 cases that were negative by NPS. Our findings are consistent with results from other studies demonstrating how saliva specimens can identify otherwise missed cases of not only COVID-19, but also influenza and RSV (4, 6, 17). In this study, of the 18 samples that were detected by NPS only, 7 (38.9%) were from asymptomatic adults, a subpopulation that performed poorly with detection of SARS-CoV-2 in saliva.…”
Section: Discussionsupporting
confidence: 92%
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD).
Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD.
The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC).
Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
“…It is important to note that testing of saliva caught 10 additional COVID-19 cases that were negative by NPS. Our findings are consistent with results from other studies demonstrating how saliva specimens can identify otherwise missed cases of not only COVID-19, but also influenza and RSV (4,6,20). In this study, of the 18 samples that were detected by NPS only, 7…”
Section: Downloaded Fromsupporting
confidence: 92%
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD).
Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD.
The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC).
Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
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