| edit |
| Hemokin (C-C motiv) ligand 9 | |||
|---|---|---|---|
| Identifikatori | |||
| Simboli | CCL9; CCF18; MRP-2; Scya9; Scya10; Ccl9 | ||
| Vanjski ID | MGI: 104533 HomoloGene: 86734 | ||
| Ortolozi | |||
| Vrsta | Čovek | Miš | |
| Entrez | n/a | 20308 | |
| Ensembl | n/a | ENSMUSG00000019122 | |
| UniProt | n/a | P51670 | |
| RefSeq (mRNA) | n/a | NM_011338 | |
| RefSeq (protein) | n/a | NP_035468 | |
| Lokacija (UCSC) | n/a | Chr 11: 83.39 - 83.39 Mb | |
| PubMed pretraga | n/a | [1] | |
CCL9, hemokin (C-C motiv) ligand 9, je mali citokin iz CC hemokin familije. On se naziva makrofagni inflamatorni protein-1 gama (MIP-1γ), protein-2 koji je sličan macrofagnom inflamatornom proteinu (MRP-2) i CCF18. Bio je opisan kod glodara. CCL9 je ranije imao oznaku CCL10. Ta oznaka se više ne koristi. On se izlučuje iz folikl-asociranog epitelijuma (FAE). CCL9 privlači dendritske ćelije koje poseduju CD11b molekule na ćelijskoj površini i hemokin receptor CCR1.[1] CCL9 može da aktivira osteoklaste putem njegovog receptora CCR1 (koji je najobilniji hemokin receptor na osteoklastima) što ide u podršku važnosti CCL9 uloge u resoprciji kostiju.[2] CCL9 je konstitutivno izražen u makrofagama i mijeloidnim ćelijama.[3][4] Gen za CCL9 je lociran na hromozomu 11 kod miševa.[4][5]
- ↑ Zhao X, Sato A, Dela Cruz C, Linehan M, Luegering A, Kucharzik T, Shirakawa A, Marquez G, Farber J, Williams I, Iwasaki A (2003). „CCL9 is secreted by the follicle-associated epithelium and recruits dome region Peyer's patch CD11b+ dendritic cells”. J Immunol 171 (6): 2797–803. PMID 12960300.
- ↑ Lean J, Murphy C, Fuller K, Chambers T (2002). „CCL9/MIP-1gamma and its receptor CCR1 are the major chemokine ligand/receptor species expressed by osteoclasts”. J Cell Biochem 87 (4): 386–93. DOI:10.1002/jcb.10319. PMID 12397598.
- ↑ Youn B, Jang I, Broxmeyer H, Cooper S, Jenkins N, Gilbert D, Copeland N, Elick T, Fraser M, Kwon B (1995). „A novel chemokine, macrophage inflammatory protein-related protein-2, inhibits colony formation of bone marrow myeloid progenitors”. J Immunol 155 (5): 2661–7. PMID 7650394.
- ↑ 4,0 4,1 Hara T, Bacon K, Cho L, Yoshimura A, Morikawa Y, Copeland N, Gilbert D, Jenkins N, Schall T, Miyajima A (1995). „Molecular cloning and functional characterization of a novel member of the C-C chemokine family”. J Immunol 155 (11): 5352–8. PMID 7594550.
- ↑ Mire-Sluis, Anthony R.; Thorpe, Robin, ur. (1998). Cytokines (Handbook of Immunopharmacology). Boston: Academic Press. ISBN 0-12-498340-5.