Can Codestral 22B run on AMD Instinct MI250X 128GB?

YES — Runs Great

B57Good

○Estimated from fit model

Codestral 22B needs ~29.6 GB VRAM. AMD Instinct MI250X 128GB has 128.0 GB. With Q4_K_M quantization, expect ~186 tok/s.

Runtime: llama.cppCapacity: RoomyBandwidth: HighStack: StandardBottleneck: Balanced

Operating mode

Choose the run profile you care about

Interactive favors responsiveness, while light API and scale-out lean harder on serving readiness. The fit stays the same, but the recommendation lens changes.

Current mode

Balanced

Balanced for general local use. Keeps the ranking neutral across personal and serving workflows.

Capabilities:

Select quantization to explore

Q4_K_M (Medium quality) — 29.6 GB, 199.9 tok/s, Runs well

29.6 GB required128.0 GB available

23% VRAM used

Fit status

Runs well

Decode

199.9 tok/s

TTFT

968 ms

Safe context

33K

Memory

29.6 GB / 128.0 GB

Memory breakdown

Weights13.4 GB

KV Cache2.4 GB

Runtime0.9 GB

Headroom12.8 GB

See how fast it feels

See how fast it feelsCodestral 22B on AMD Instinct MI250X 128GB
1st promptCold start — includes initialization
>Write a Python function to sort a list
Here's a Python function that sorts a list using quicksort:

def quicksort(arr):
 if len(arr) <= 1:
 return arr
 pivot = arr[len(arr) // 2]
 left = [x for x in arr if x < pivot]
 middle = [x for x in arr if x == pivot]
 right = [x for x in arr if x > pivot]
 return quicksort(left) + middle + quicksort(right)

# Example usage
numbers = [3, 6, 8, 10, 1, 2, 1]
print(quicksort(numbers)) # [1, 1, 2, 3, 6, 8, 10]

The algorithm picks a pivot, partitions the list into smaller, equal, and larger elements, then recursively sorts each partition and concatenates the results.
2nd promptWarm — model ready, no init overhead
>Now add type hints and a docstring
def quicksort(arr: list[int]) -> list[int]:
 """Sort a list using the quicksort algorithm.

 Args:
 arr: List of integers to sort.

 Returns:
 A new sorted list.
 """
 if len(arr) <= 1:
 return arr
 pivot = arr[len(arr) // 2]
 left = [x for x in arr if x < pivot]
 middle = [x for x in arr if x == pivot]
 right = [x for x in arr if x > pivot]
 return quicksort(left) + middle + quicksort(right)

Added type hints for the input and return type, plus a Google-style docstring.
Estimated: 199.9 tok/s decode · 968ms TTFT (warm) · 500 tok/s prefill

What limits this setup

This setup is broadly balanced for this model.

No major red flags

This recommendation has enough memory headroom and acceptable estimated speed for the selected workload.

Best improvement path

Performance by workload

Workload	Grade	Fit	Decode	TTFT	Context
Chat	B	Runs well	199.9 tok/s	528 ms	33K
Coding	B	Runs well	186.0 tok/s	1041 ms	33K
Agentic Coding	B	Runs well	199.9 tok/s	1408 ms	33K
Reasoning	B	Runs well	199.9 tok/s	1144 ms	33K
RAG	B	Runs well	199.9 tok/s	1761 ms	33K

Quantization options

How Codestral 22B (22B params) fits at each quantization level on AMD Instinct MI250X 128GB (128.0 GB usable).

Quant	Bits	VRAM	Quality	Fit
Q2_K	2	8.6 GB	Low	C48
Q3_K_S	3	10.8 GB	Low	C48
NVFP4	4

Get started

Copy-paste commands to run Codestral 22B on your machine.

Run

ollama run codestral

Frequently asked questions

See all results for AMD Instinct MI250X 128GB See all hardware for Codestral 22B

URL: https://willitrunai.com/can-run/codestral-22b-on-instinct-mi250x-128gb

⇱