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URL: https://willitrunai.com/can-run/command-r-plus-104b-on-instinct-mi250-128gb

⇱ Command R+ 104B on AMD Instinct MI250 128GB? YES


Can Command R+ 104B run on AMD Instinct MI250 128GB?

YES — Runs Great

B70Good
Estimated from fit model

Command R+ 104B needs ~80.6 GB VRAM. AMD Instinct MI250 128GB has 128.0 GB. With Q4_K_M quantization, expect ~37 tok/s.

Runtime: llama.cppCapacity: RoomyBandwidth: HighStack: StandardBottleneck: Balanced
Share:

Operating mode

Choose the run profile you care about

Interactive favors responsiveness, while light API and scale-out lean harder on serving readiness. The fit stays the same, but the recommendation lens changes.

Current mode

Balanced

Balanced for general local use. Keeps the ranking neutral across personal and serving workflows.

Capabilities:

Select quantization to explore

Q4_K_M (Medium quality) — 80.6 GB, 37.3 tok/s, Runs well
80.6 GB required128.0 GB available
63% VRAM used

Fit status

Runs well

Decode

37.3 tok/s

TTFT

5190 ms

Safe context

131K

Memory

80.6 GB / 128.0 GB

Memory breakdown

Weights63.4 GB
KV Cache3.4 GB
Runtime0.9 GB
Headroom12.8 GB

See how fast it feels

See how fast it feelsCommand R+ 104B on AMD Instinct MI250 128GB
1st promptCold start — includes initialization
>Solve: If a train travels at 60 mph for 2.5 hours, how far does it go?
Let me work through this step by step. Given information: - Speed = 60 mph (miles per hour) - Time = 2.5 hours Formula: Distance = Speed x Time Calculation: Distance = 60 mph x 2.5 h = 150 miles The train travels 150 miles. Double-check: at 60 mph the train covers 60 miles each hour. In half an hour it covers 30 miles. So in 2.5 hours: 60 + 60 + 30 = 150 miles. Confirmed.
2nd promptWarm — model ready, no init overhead
>What if the train stops for 20 minutes halfway?
The stop doesn't change the total distance covered while moving, but it affects total trip time. Breakdown: - First half: 1.25 hours at 60 mph = 75 miles - Stop: 20 minutes (no distance) - Second half: 1.25 hours at 60 mph = 75 miles Total distance: 150 miles (same) Total time: 2.5 h + 0.33 h = 2.83 hours Average speed: 150 / 2.83 = 53 mph The distance stays the same but average speed drops to 53 mph because of the stop.
Estimated: 37.3 tok/s decode · 5.2s TTFT (warm) · 93 tok/s prefill

What limits this setup

This setup is broadly balanced for this model.

No major red flags

This recommendation has enough memory headroom and acceptable estimated speed for the selected workload.

Best improvement path

Performance by workload

WorkloadGradeFitDecodeTTFTContext
ChatBRuns well37.3 tok/s2831 ms131K
CodingBRuns well37.3 tok/s5190 ms131K
Agentic CodingARuns well37.3 tok/s7549 ms131K
ReasoningBRuns well37.3 tok/s6134 ms131K
RAGARuns well37.3 tok/s9437 ms131K

Quantization options

How Command R+ 104B (104B params) fits at each quantization level on AMD Instinct MI250 128GB (128.0 GB usable).

QuantBitsVRAMQualityFit
Q2_K
2
40.6 GB
LowB60
Q3_K_S
3
51.0 GB
LowB62
NVFP4
4
58.2 GB
MediumB63
Q4_K_M
4
63.4 GB
MediumB64
Q5_K_M
5
74.9 GB
HighB65
Q6_KBest for your GPU
6
85.3 GB
HighB65
Q8_0
8
111.3 GB
Very HighF0
F16
16
213.2 GB
MaximumF0

Get started

Copy-paste commands to run Command R+ 104B on your machine.

Run

ollama run command-r-plus

Upgrade options

Hardware that runs Command R+ 104B well

👁 NVIDIA
NVIDIA H200 141GBBudget pick
141 GB VRAM (+13)4800 GB/s (+1600)
A
Raises estimated decode speed by about 85%.69.1 tok/s decode

Raises estimated decode speed by about 85%.

~$30,000 MSRP

👁 NVIDIA
NVIDIA H200 PCIe 141GBBest value
141 GB VRAM (+13)4800 GB/s (+1600)
A
Raises estimated decode speed by about 85%.69.1 tok/s decode

Raises estimated decode speed by about 85%.

~$30,000 MSRP

Frequently asked questions

See all results for AMD Instinct MI250 128GBSee all hardware for Command R+ 104B