Can Devstral 2 123B Instruct run on AMD Instinct MI250 128GB?

YES — Runs Great

S97Excellent

○Estimated from fit model

Devstral 2 123B Instruct needs ~94.1 GB VRAM. AMD Instinct MI250 128GB has 128.0 GB. With Q4_K_M quantization, expect ~32 tok/s.

Runtime: llama.cppCapacity: RoomyBandwidth: HighStack: StandardBottleneck: Balanced

Operating mode

Choose the run profile you care about

Interactive favors responsiveness, while light API and scale-out lean harder on serving readiness. The fit stays the same, but the recommendation lens changes.

Current mode

Balanced

Balanced for general local use. Keeps the ranking neutral across personal and serving workflows.

Capabilities:

Select quantization to explore

Q4_K_M (Medium quality) — 94.1 GB, 31.5 tok/s, Runs well

94.1 GB required128.0 GB available

74% VRAM used

Fit status

Runs well

Decode

31.5 tok/s

TTFT

6138 ms

Safe context

117K

Memory

94.1 GB / 128.0 GB

Memory breakdown

Weights75.0 GB

KV Cache5.4 GB

Runtime0.9 GB

Headroom12.8 GB

See how fast it feels

See how fast it feelsDevstral 2 123B Instruct on AMD Instinct MI250 128GB
1st promptCold start — includes initialization
>Write a Python function to sort a list
Here's a Python function that sorts a list using quicksort:

def quicksort(arr):
 if len(arr) <= 1:
 return arr
 pivot = arr[len(arr) // 2]
 left = [x for x in arr if x < pivot]
 middle = [x for x in arr if x == pivot]
 right = [x for x in arr if x > pivot]
 return quicksort(left) + middle + quicksort(right)

# Example usage
numbers = [3, 6, 8, 10, 1, 2, 1]
print(quicksort(numbers)) # [1, 1, 2, 3, 6, 8, 10]

The algorithm picks a pivot, partitions the list into smaller, equal, and larger elements, then recursively sorts each partition and concatenates the results.
2nd promptWarm — model ready, no init overhead
>Now add type hints and a docstring
def quicksort(arr: list[int]) -> list[int]:
 """Sort a list using the quicksort algorithm.

 Args:
 arr: List of integers to sort.

 Returns:
 A new sorted list.
 """
 if len(arr) <= 1:
 return arr
 pivot = arr[len(arr) // 2]
 left = [x for x in arr if x < pivot]
 middle = [x for x in arr if x == pivot]
 right = [x for x in arr if x > pivot]
 return quicksort(left) + middle + quicksort(right)

Added type hints for the input and return type, plus a Google-style docstring.
Estimated: 31.5 tok/s decode · 6.1s TTFT (warm) · 79 tok/s prefill

What limits this setup

This setup is broadly balanced for this model.

No major red flags

This recommendation has enough memory headroom and acceptable estimated speed for the selected workload.

Best improvement path

Performance by workload

Workload	Grade	Fit	Decode	TTFT	Context
Chat	S	Runs well	31.5 tok/s	3348 ms	117K
Coding	S	Runs well	31.5 tok/s	6138 ms	117K
Agentic Coding	S	Runs well	31.5 tok/s	8929 ms	117K
Reasoning	S	Runs well	31.5 tok/s	7254 ms	117K
RAG	S	Runs well	31.5 tok/s	11161 ms	117K

Quantization options

How Devstral 2 123B Instruct (123B params) fits at each quantization level on AMD Instinct MI250 128GB (128.0 GB usable).

Quant	Bits	VRAM	Quality	Fit
Q2_K	2	48.0 GB	Low	S88
Q3_K_S	3	60.3 GB	Low	S90
NVFP4	4

Get started

Copy-paste commands to run Devstral 2 123B Instruct on your machine.

Run

lms load Devstral-2-123B-Instruct-2512 && lms server start

Frequently asked questions

See all results for AMD Instinct MI250 128GB See all hardware for Devstral 2 123B Instruct

URL: https://willitrunai.com/can-run/devstral-2-123b-on-instinct-mi250-128gb

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