Can Falcon 40B Instruct run on AMD Instinct MI250 128GB?

YES — Runs Great

B70Good

○Estimated from fit model

Falcon 40B Instruct needs ~44.6 GB VRAM. AMD Instinct MI250 128GB has 128.0 GB. With Q5_K_M quantization, expect ~84 tok/s.

Runtime: OllamaCapacity: RoomyBandwidth: HighStack: BasicBottleneck: Balanced

Operating mode

Choose the run profile you care about

Interactive favors responsiveness, while light API and scale-out lean harder on serving readiness. The fit stays the same, but the recommendation lens changes.

Current mode

Balanced

Balanced for general local use. Keeps the ranking neutral across personal and serving workflows.

Capabilities:

Select quantization to explore

Q5_K_M (High quality) — 44.6 GB, 83.8 tok/s, Runs well

44.6 GB required128.0 GB available

35% VRAM used

Fit status

Runs well

Decode

83.8 tok/s

TTFT

2310 ms

Safe context

Memory

44.6 GB / 128.0 GB

Memory breakdown

Weights28.8 GB

KV Cache1.8 GB

Runtime1.2 GB

Headroom12.8 GB

See how fast it feels

See how fast it feelsFalcon 40B Instruct on AMD Instinct MI250 128GB
1st promptCold start — includes initialization
>Solve: If a train travels at 60 mph for 2.5 hours, how far does it go?
Let me work through this step by step.

Given information:
 - Speed = 60 mph (miles per hour)
 - Time = 2.5 hours

Formula: Distance = Speed x Time

Calculation:
 Distance = 60 mph x 2.5 h
 = 150 miles

The train travels 150 miles.

Double-check: at 60 mph the train covers 60 miles each hour. In half an hour it covers 30 miles. So in 2.5 hours: 60 + 60 + 30 = 150 miles. Confirmed.
2nd promptWarm — model ready, no init overhead
>What if the train stops for 20 minutes halfway?
The stop doesn't change the total distance covered while moving, but it affects total trip time.

Breakdown:
 - First half: 1.25 hours at 60 mph = 75 miles
 - Stop: 20 minutes (no distance)
 - Second half: 1.25 hours at 60 mph = 75 miles

Total distance: 150 miles (same)
Total time: 2.5 h + 0.33 h = 2.83 hours
Average speed: 150 / 2.83 = 53 mph

The distance stays the same but average speed drops to 53 mph because of the stop.
Estimated: 83.8 tok/s decode · 2.3s TTFT (warm) · 210 tok/s prefill

What limits this setup

This setup is broadly balanced for this model.

No major red flags

This recommendation has enough memory headroom and acceptable estimated speed for the selected workload.

Best improvement path

Performance by workload

Workload	Grade	Fit	Decode	TTFT	Context
Chat	B	Runs well	83.8 tok/s	1260 ms	8K
Coding	B	Runs well	83.8 tok/s	2310 ms	8K
Agentic Coding	A	Runs well	83.8 tok/s	3360 ms	8K
Reasoning	B	Runs well	83.8 tok/s	2730 ms	8K
RAG	A	Runs well	83.8 tok/s	4200 ms	8K

Quantization options

How Falcon 40B Instruct (40B params) fits at each quantization level on AMD Instinct MI250 128GB (128.0 GB usable).

Quant	Bits	VRAM	Quality	Fit
Q2_K	2	15.6 GB	Low	B59
Q3_K_S	3	19.6 GB	Low	B60
NVFP4	4

Get started

Copy-paste commands to run Falcon 40B Instruct on your machine.

Run

docker run --rm -it ghcr.io/ggerganov/llama.cpp:full \
 --hf-repo "tiiuae/falcon-40b-instruct" \
 --hf-file "falcon-40b-instruct-Q5_K_M.gguf" \
 -c 4096 -ngl 99

Frequently asked questions

See all results for AMD Instinct MI250 128GB See all hardware for Falcon 40B Instruct

URL: https://willitrunai.com/can-run/falcon-40b-instruct-on-instinct-mi250-128gb

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