Can Gemma 3 27B run on AMD Instinct MI350X 288GB?

YES — Runs Great

A79Great

○Estimated from fit model

Gemma 3 27B needs ~57.4 GB VRAM. AMD Instinct MI350X 288GB has 288.0 GB. With Q4_K_M quantization, expect ~231 tok/s.

Runtime: llama.cppCapacity: RoomyBandwidth: HighStack: StandardBottleneck: Balanced

Operating mode

Choose the run profile you care about

Interactive favors responsiveness, while light API and scale-out lean harder on serving readiness. The fit stays the same, but the recommendation lens changes.

Current mode

Balanced

Balanced for general local use. Keeps the ranking neutral across personal and serving workflows.

Capabilities:

Select quantization to explore

Q4_K_M (Medium quality) — 57.4 GB, 231.4 tok/s, Runs well

57.4 GB required288.0 GB available

20% VRAM used

Fit status

Runs well

Decode

231.4 tok/s

TTFT

837 ms

Safe context

131K

Memory

57.4 GB / 288.0 GB

Memory breakdown

Weights16.5 GB

KV Cache11.2 GB

Runtime0.9 GB

Headroom28.8 GB

See how fast it feels

See how fast it feelsGemma 3 27B on AMD Instinct MI350X 288GB
1st promptCold start — includes initialization
>Write a Python function to sort a list
Here's a Python function that sorts a list using quicksort:

def quicksort(arr):
 if len(arr) <= 1:
 return arr
 pivot = arr[len(arr) // 2]
 left = [x for x in arr if x < pivot]
 middle = [x for x in arr if x == pivot]
 right = [x for x in arr if x > pivot]
 return quicksort(left) + middle + quicksort(right)

# Example usage
numbers = [3, 6, 8, 10, 1, 2, 1]
print(quicksort(numbers)) # [1, 1, 2, 3, 6, 8, 10]

The algorithm picks a pivot, partitions the list into smaller, equal, and larger elements, then recursively sorts each partition and concatenates the results.
2nd promptWarm — model ready, no init overhead
>Now add type hints and a docstring
def quicksort(arr: list[int]) -> list[int]:
 """Sort a list using the quicksort algorithm.

 Args:
 arr: List of integers to sort.

 Returns:
 A new sorted list.
 """
 if len(arr) <= 1:
 return arr
 pivot = arr[len(arr) // 2]
 left = [x for x in arr if x < pivot]
 middle = [x for x in arr if x == pivot]
 right = [x for x in arr if x > pivot]
 return quicksort(left) + middle + quicksort(right)

Added type hints for the input and return type, plus a Google-style docstring.
Estimated: 231.4 tok/s decode · 837ms TTFT (warm) · 578 tok/s prefill

What limits this setup

This setup is broadly balanced for this model.

No major red flags

This recommendation has enough memory headroom and acceptable estimated speed for the selected workload.

Best improvement path

Performance by workload

Workload	Grade	Fit	Decode	TTFT	Context
Chat	A	Runs well	231.4 tok/s	456 ms	131K
Coding	A	Runs well	231.4 tok/s	837 ms	131K
Agentic Coding	A	Runs well	231.4 tok/s	1217 ms	131K
Reasoning	A	Runs well	231.4 tok/s	989 ms	131K
RAG	A	Runs well	231.4 tok/s	1521 ms	131K

Quantization options

How Gemma 3 27B (27B params) fits at each quantization level on AMD Instinct MI350X 288GB (288.0 GB usable).

Quant	Bits	VRAM	Quality	Fit
Q2_K	2	10.5 GB	Low	B68
Q3_K_S	3	13.2 GB	Low	B69
NVFP4	4	15.1 GB	Medium	B69
Q4_K_M	4	16.5 GB	Medium	B69
Q5_K_M	5	19.4 GB	High	B69
Q6_K	6	22.1 GB	High	B69
Q8_0	8	28.9 GB	Very High	B70
F16Best for your GPU	16	55.4 GB	Maximum	A72

Get started

Copy-paste commands to run Gemma 3 27B on your machine.

Run

ollama run gemma3

Your hardware

More models your AMD Instinct MI350X 288GB can run

Model	Params	Grade	Decode
👁 Alibaba Qwen 3.5 397B A17B	397B	S	78.9 tok/s
👁 Mistral Devstral 2 123B Instruct	123B	S	84.6 tok/s
👁 Alibaba Qwen3-Coder 30B A3B Instruct	30.5B	S	883.1 tok/s
👁 Alibaba Qwen 3.5 122B A10B	122B	S	234.8 tok/s
👁 DeepSeek DeepSeek V4 Flash	284B	S	125.8 tok/s

Frequently asked questions

See all results for AMD Instinct MI350X 288GB See all hardware for Gemma 3 27B

URL: https://willitrunai.com/can-run/gemma-3-27b-on-instinct-mi350x-288gb

⇱ Gemma 3 27B on AMD Instinct MI350X 288GB? YES