Can Gemma 4 E4B run on AMD Instinct MI250X 128GB?

YES — Runs Great

A73Great

○Estimated from fit model

Gemma 4 E4B needs ~19.9 GB VRAM. AMD Instinct MI250X 128GB has 128.0 GB. With Q4_K_M quantization, expect ~112 tok/s.

Runtime: llama.cppCapacity: RoomyBandwidth: HighStack: StandardBottleneck: Balanced

Operating mode

Choose the run profile you care about

Interactive favors responsiveness, while light API and scale-out lean harder on serving readiness. The fit stays the same, but the recommendation lens changes.

Current mode

Balanced

Balanced for general local use. Keeps the ranking neutral across personal and serving workflows.

Capabilities:

Select quantization to explore

Q4_K_M (Medium quality) — 19.9 GB, 112.0 tok/s, Runs well

19.9 GB required128.0 GB available

16% VRAM used

Fit status

Runs well

Decode

112.0 tok/s

TTFT

1729 ms

Safe context

128K

Memory

19.9 GB / 128.0 GB

Memory breakdown

Weights4.9 GB

KV Cache1.3 GB

Runtime0.9 GB

Headroom12.8 GB

See how fast it feels

See how fast it feelsGemma 4 E4B on AMD Instinct MI250X 128GB
1st promptCold start — includes initialization
>Write a Python function to sort a list
Here's a Python function that sorts a list using quicksort:

def quicksort(arr):
 if len(arr) <= 1:
 return arr
 pivot = arr[len(arr) // 2]
 left = [x for x in arr if x < pivot]
 middle = [x for x in arr if x == pivot]
 right = [x for x in arr if x > pivot]
 return quicksort(left) + middle + quicksort(right)

# Example usage
numbers = [3, 6, 8, 10, 1, 2, 1]
print(quicksort(numbers)) # [1, 1, 2, 3, 6, 8, 10]

The algorithm picks a pivot, partitions the list into smaller, equal, and larger elements, then recursively sorts each partition and concatenates the results.
2nd promptWarm — model ready, no init overhead
>Now add type hints and a docstring
def quicksort(arr: list[int]) -> list[int]:
 """Sort a list using the quicksort algorithm.

 Args:
 arr: List of integers to sort.

 Returns:
 A new sorted list.
 """
 if len(arr) <= 1:
 return arr
 pivot = arr[len(arr) // 2]
 left = [x for x in arr if x < pivot]
 middle = [x for x in arr if x == pivot]
 right = [x for x in arr if x > pivot]
 return quicksort(left) + middle + quicksort(right)

Added type hints for the input and return type, plus a Google-style docstring.
Estimated: 112.0 tok/s decode · 1.7s TTFT (warm) · 280 tok/s prefill

What limits this setup

This setup is broadly balanced for this model.

No major red flags

This recommendation has enough memory headroom and acceptable estimated speed for the selected workload.

Best improvement path

Performance by workload

Workload	Grade	Fit	Decode	TTFT	Context
Chat	A	Runs well	112.0 tok/s	943 ms	128K
Coding	A	Runs well	112.0 tok/s	1729 ms	128K
Agentic Coding	A	Runs well	112.0 tok/s	2514 ms	128K
Reasoning	A	Runs well	112.0 tok/s	2043 ms	128K
RAG	A	Runs well	112.0 tok/s	3143 ms	128K

Quantization options

How Gemma 4 E4B (8B params) fits at each quantization level on AMD Instinct MI250X 128GB (128.0 GB usable).

Quant	Bits	VRAM	Quality	Fit
Q2_K	2	3.1 GB	Low	B66
Q3_K_S	3	3.9 GB	Low	B66
NVFP4	4	4.5 GB	Medium	B66
Q4_K_M	4	4.9 GB	Medium	B66
Q5_K_M	5	5.8 GB	High	B66
Q6_K	6	6.6 GB	High	B66
Q8_0	8	8.6 GB	Very High	B66
F16Best for your GPU	16	16.4 GB	Maximum	B66

Get started

Copy-paste commands to run Gemma 4 E4B on your machine.

Run

ollama run gemma4:e4b

Your hardware

More models your AMD Instinct MI250X 128GB can run

Model	Params	Grade	Decode
👁 Mistral Devstral 2 123B Instruct	123B	S	36.2 tok/s
👁 Alibaba Qwen3-Coder 30B A3B Instruct	30.5B	S	377.4 tok/s
👁 Alibaba Qwen 3.5 27B	27B	S	163.7 tok/s
👁 Alibaba Qwen 3.6 27B	27B	S	102 tok/s
👁 Alibaba Qwen 3.5 122B A10B	122B	S	100.3 tok/s

Frequently asked questions

See all results for AMD Instinct MI250X 128GB See all hardware for Gemma 4 E4B

URL: https://willitrunai.com/can-run/gemma-4-e4b-on-instinct-mi250x-128gb

⇱ Gemma 4 E4B on AMD Instinct MI250X 128GB? YES