Can Hermes 4.3 36B run on AMD Instinct MI325X 256GB?

YES — Runs Great

C46Usable

○Estimated from fit model

Hermes 4.3 36B needs ~52.7 GB VRAM. AMD Instinct MI325X 256GB has 256.0 GB. With Q4_K_M quantization, expect ~200 tok/s.

Runtime: llama.cppCapacity: RoomyBandwidth: HighStack: StandardBottleneck: Balanced

Operating mode

Choose the run profile you care about

Interactive favors responsiveness, while light API and scale-out lean harder on serving readiness. The fit stays the same, but the recommendation lens changes.

Current mode

Balanced

Balanced for general local use. Keeps the ranking neutral across personal and serving workflows.

Capabilities:

Select quantization to explore

Q4_K_M (Medium quality) — 52.7 GB, 199.5 tok/s, Runs well

52.7 GB required256.0 GB available

21% VRAM used

Fit status

Runs well

Decode

199.5 tok/s

TTFT

971 ms

Safe context

787K

Memory

52.7 GB / 256.0 GB

Memory breakdown

Weights22.0 GB

KV Cache4.2 GB

Runtime0.9 GB

Headroom25.6 GB

See how fast it feels

See how fast it feelsHermes 4.3 36B on AMD Instinct MI325X 256GB
1st promptCold start — includes initialization
>Solve: If a train travels at 60 mph for 2.5 hours, how far does it go?
Let me work through this step by step.

Given information:
 - Speed = 60 mph (miles per hour)
 - Time = 2.5 hours

Formula: Distance = Speed x Time

Calculation:
 Distance = 60 mph x 2.5 h
 = 150 miles

The train travels 150 miles.

Double-check: at 60 mph the train covers 60 miles each hour. In half an hour it covers 30 miles. So in 2.5 hours: 60 + 60 + 30 = 150 miles. Confirmed.
2nd promptWarm — model ready, no init overhead
>What if the train stops for 20 minutes halfway?
The stop doesn't change the total distance covered while moving, but it affects total trip time.

Breakdown:
 - First half: 1.25 hours at 60 mph = 75 miles
 - Stop: 20 minutes (no distance)
 - Second half: 1.25 hours at 60 mph = 75 miles

Total distance: 150 miles (same)
Total time: 2.5 h + 0.33 h = 2.83 hours
Average speed: 150 / 2.83 = 53 mph

The distance stays the same but average speed drops to 53 mph because of the stop.
Estimated: 199.5 tok/s decode · 971ms TTFT (warm) · 499 tok/s prefill

What limits this setup

This setup is broadly balanced for this model.

No major red flags

This recommendation has enough memory headroom and acceptable estimated speed for the selected workload.

Best improvement path

Performance by workload

Workload	Grade	Fit	Decode	TTFT	Context
Chat	C	Runs well	199.5 tok/s	529 ms	787K
Coding	C	Runs well	199.5 tok/s	971 ms	787K
Agentic Coding	C	Runs well	199.5 tok/s	1412 ms	787K
Reasoning	C	Runs well	199.5 tok/s	1147 ms	787K
RAG	C	Runs well	199.5 tok/s	1765 ms	787K

Quantization options

How Hermes 4.3 36B (36B params) fits at each quantization level on AMD Instinct MI325X 256GB (256.0 GB usable).

Quant	Bits	VRAM	Quality	Fit
Q2_K	2	14.0 GB	Low	D36
Q3_K_S	3	17.6 GB	Low	D37
NVFP4	4

Get started

Copy-paste commands to run Hermes 4.3 36B on your machine.

Run

lms load hf-nousresearch--hermes-4-3-36b-gguf && lms server start

Frequently asked questions

See all results for AMD Instinct MI325X 256GB See all hardware for Hermes 4.3 36B

URL: https://willitrunai.com/can-run/hf-nousresearch--hermes-4-3-36b-gguf-on-instinct-mi325x-256gb

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