Can Hermes 4.3 36B run on Quadro RTX 8000 48GB?

YES — Runs Great

C51Usable

○Estimated from fit model

Hermes 4.3 36B needs ~32.2 GB VRAM. Quadro RTX 8000 48GB has 48.0 GB. With Q4_K_M quantization, expect ~21 tok/s.

Runtime: OllamaCapacity: RoomyBandwidth: MediumStack: BasicBottleneck: Balanced

Operating mode

Choose the run profile you care about

Interactive favors responsiveness, while light API and scale-out lean harder on serving readiness. The fit stays the same, but the recommendation lens changes.

Current mode

Balanced

Balanced for general local use. Keeps the ranking neutral across personal and serving workflows.

Capabilities:

Select quantization to explore

Q4_K_M (Medium quality) — 32.2 GB, 21.1 tok/s, Runs well

32.2 GB required48.0 GB available

67% VRAM used

Fit status

Runs well

Decode

21.1 tok/s

TTFT

9169 ms

Safe context

76K

Memory

32.2 GB / 48.0 GB

Memory breakdown

Weights22.0 GB

KV Cache4.2 GB

Runtime1.2 GB

Headroom4.8 GB

See how fast it feels

See how fast it feelsHermes 4.3 36B on Quadro RTX 8000 48GB
1st promptCold start — includes initialization
>Solve: If a train travels at 60 mph for 2.5 hours, how far does it go?
Let me work through this step by step.

Given information:
 - Speed = 60 mph (miles per hour)
 - Time = 2.5 hours

Formula: Distance = Speed x Time

Calculation:
 Distance = 60 mph x 2.5 h
 = 150 miles

The train travels 150 miles.

Double-check: at 60 mph the train covers 60 miles each hour. In half an hour it covers 30 miles. So in 2.5 hours: 60 + 60 + 30 = 150 miles. Confirmed.
2nd promptWarm — model ready, no init overhead
>What if the train stops for 20 minutes halfway?
The stop doesn't change the total distance covered while moving, but it affects total trip time.

Breakdown:
 - First half: 1.25 hours at 60 mph = 75 miles
 - Stop: 20 minutes (no distance)
 - Second half: 1.25 hours at 60 mph = 75 miles

Total distance: 150 miles (same)
Total time: 2.5 h + 0.33 h = 2.83 hours
Average speed: 150 / 2.83 = 53 mph

The distance stays the same but average speed drops to 53 mph because of the stop.
Estimated: 21.1 tok/s decode · 9.2s TTFT (warm) · 53 tok/s prefill

What limits this setup

This setup is broadly balanced for this model.

Older PCIe generation

PCIe 3.0 is workable, but it compounds the penalty when you offload heavily or try to scale across multiple cards.

Best improvement path

Performance by workload

Workload	Grade	Fit	Decode	TTFT	Context
Chat	C	Runs well	21.1 tok/s	5001 ms	76K
Coding	C	Runs well	21.1 tok/s	9169 ms	76K
Agentic Coding	C	Runs well	21.1 tok/s	13337 ms	76K
Reasoning	C	Runs well	21.1 tok/s	10836 ms	76K
RAG	C	Runs well	21.1 tok/s	16671 ms	76K

Quantization options

How Hermes 4.3 36B (36B params) fits at each quantization level on Quadro RTX 8000 48GB (48.0 GB usable).

Quant	Bits	VRAM	Quality	Fit
Q2_K	2	14.0 GB	Low	C44
Q3_K_S	3	17.6 GB	Low	C45
NVFP4	4

Get started

Copy-paste commands to run Hermes 4.3 36B on your machine.

Run

lms load hf-nousresearch--hermes-4-3-36b-gguf && lms server start

Frequently asked questions

See all results for Quadro RTX 8000 48GB See all hardware for Hermes 4.3 36B

URL: https://willitrunai.com/can-run/hf-nousresearch--hermes-4-3-36b-gguf-on-quadro-rtx-8000-48gb

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