Can DeepSeek R1 Distill Qwen 14B run on AMD Instinct MI350X 288GB?

YES — Runs Great

C45Usable

○Estimated from fit model

DeepSeek R1 Distill Qwen 14B needs ~39.9 GB VRAM. AMD Instinct MI350X 288GB has 288.0 GB. With Q4_K_M quantization, expect ~196 tok/s.

Runtime: llama.cppCapacity: RoomyBandwidth: HighStack: StandardBottleneck: Balanced

Operating mode

Choose the run profile you care about

Interactive favors responsiveness, while light API and scale-out lean harder on serving readiness. The fit stays the same, but the recommendation lens changes.

Current mode

Balanced

Balanced for general local use. Keeps the ranking neutral across personal and serving workflows.

Capabilities:

Select quantization to explore

Q4_K_M (Medium quality) — 39.9 GB, 196.0 tok/s, Runs well

39.9 GB required288.0 GB available

14% VRAM used

Fit status

Runs well

Decode

196.0 tok/s

TTFT

988 ms

Safe context

2.4M

Memory

39.9 GB / 288.0 GB

Memory breakdown

Weights8.5 GB

KV Cache1.6 GB

Runtime0.9 GB

Headroom28.8 GB

See how fast it feels

See how fast it feelsDeepSeek R1 Distill Qwen 14B on AMD Instinct MI350X 288GB
1st promptCold start — includes initialization
>Solve: If a train travels at 60 mph for 2.5 hours, how far does it go?
Let me work through this step by step.

Given information:
 - Speed = 60 mph (miles per hour)
 - Time = 2.5 hours

Formula: Distance = Speed x Time

Calculation:
 Distance = 60 mph x 2.5 h
 = 150 miles

The train travels 150 miles.

Double-check: at 60 mph the train covers 60 miles each hour. In half an hour it covers 30 miles. So in 2.5 hours: 60 + 60 + 30 = 150 miles. Confirmed.
2nd promptWarm — model ready, no init overhead
>What if the train stops for 20 minutes halfway?
The stop doesn't change the total distance covered while moving, but it affects total trip time.

Breakdown:
 - First half: 1.25 hours at 60 mph = 75 miles
 - Stop: 20 minutes (no distance)
 - Second half: 1.25 hours at 60 mph = 75 miles

Total distance: 150 miles (same)
Total time: 2.5 h + 0.33 h = 2.83 hours
Average speed: 150 / 2.83 = 53 mph

The distance stays the same but average speed drops to 53 mph because of the stop.
Estimated: 196.0 tok/s decode · 988ms TTFT (warm) · 490 tok/s prefill

What limits this setup

This setup is broadly balanced for this model.

No major red flags

This recommendation has enough memory headroom and acceptable estimated speed for the selected workload.

Best improvement path

Performance by workload

Workload	Grade	Fit	Decode	TTFT	Context
Chat	C	Runs well	196.0 tok/s	539 ms	2.4M
Coding	C	Runs well	196.0 tok/s	988 ms	2.4M
Agentic Coding	C	Runs well	196.0 tok/s	1437 ms	2.4M
Reasoning	C	Runs well	196.0 tok/s	1167 ms	2.4M
RAG	C	Runs well	196.0 tok/s	1796 ms	2.4M

Quantization options

How DeepSeek R1 Distill Qwen 14B (14B params) fits at each quantization level on AMD Instinct MI350X 288GB (288.0 GB usable).

Quant	Bits	VRAM	Quality	Fit
Q2_K	2	5.5 GB	Low	D36
Q3_K_S	3	6.9 GB	Low	D36
NVFP4	4	7.8 GB	Medium	D36
Q4_K_M	4	8.5 GB	Medium	D36
Q5_K_M	5	10.1 GB	High	D36
Q6_K	6	11.5 GB	High	D36
Q8_0	8	15.0 GB	Very High	D36
F16Best for your GPU	16	28.7 GB	Maximum	D37

Get started

Copy-paste commands to run DeepSeek R1 Distill Qwen 14B on your machine.

Run

lms load hf-unsloth--deepseek-r1-distill-qwen-14b-gguf && lms server start

Frequently asked questions

See all results for AMD Instinct MI350X 288GB See all hardware for DeepSeek R1 Distill Qwen 14B

URL: https://willitrunai.com/can-run/hf-unsloth--deepseek-r1-distill-qwen-14b-gguf-on-instinct-mi350x-288gb

⇱ DeepSeek R1 Distill Qwen 14B on AMD Instinct MI350X 288GB? …