VOOZH about

URL: https://willitrunai.com/can-run/llama-3.1-405b-on-b100-192gb


Can Llama 3.1 405B run on B100 192GB?

YES — With Q3_K_S

B67Good
Estimated from fit model

Llama 3.1 405B needs ~226.2 GB VRAM. B100 192GB has 192.0 GB. With Q3_K_S quantization, expect ~22 tok/s.

Runtime: llama.cppCapacity: OffloadBandwidth: HighStack: StandardBottleneck: Host offload
Share:

Operating mode

Choose the run profile you care about

Interactive favors responsiveness, while light API and scale-out lean harder on serving readiness. The fit stays the same, but the recommendation lens changes.

Current mode

Balanced

Balanced for general local use. Keeps the ranking neutral across personal and serving workflows.

Llama 3.1 405B at Q4_K_M needs 274.8 GB — too much for B100 192GB (192.0 GB). Runs at Q3_K_S (226.2 GB) with low quality. 2 quantization levels fit.
Capabilities:

Select quantization to explore

Q4_K_M (Medium quality) — 274.8 GB, exceeds 192.0 GB available
274.8 GB required192.0 GB available
143% VRAM needed

82.8 GB over capacity — needs offload or smaller quantization

Fit status

Too heavy

Decode

14.0 tok/s

TTFT

13789 ms

Safe context

4K

Memory

274.8 GB / 192.0 GB

Offload

30%

Memory breakdown

Weights247.1 GB
KV Cache7.7 GB
Runtime0.9 GB
Headroom19.2 GB

See how fast it feels

With memory offload — actual speed may be lower
See how fast it feelsLlama 3.1 405B on B100 192GB
1st promptCold start — includes initialization
>Write a Python function to sort a list
Here's a Python function that sorts a list using quicksort: def quicksort(arr): if len(arr) <= 1: return arr pivot = arr[len(arr) // 2] left = [x for x in arr if x < pivot] middle = [x for x in arr if x == pivot] right = [x for x in arr if x > pivot] return quicksort(left) + middle + quicksort(right) # Example usage numbers = [3, 6, 8, 10, 1, 2, 1] print(quicksort(numbers)) # [1, 1, 2, 3, 6, 8, 10] The algorithm picks a pivot, partitions the list into smaller, equal, and larger elements, then recursively sorts each partition and concatenates the results.
2nd promptWarm — model ready, no init overhead
>Now add type hints and a docstring
def quicksort(arr: list[int]) -> list[int]: """Sort a list using the quicksort algorithm. Args: arr: List of integers to sort. Returns: A new sorted list. """ if len(arr) <= 1: return arr pivot = arr[len(arr) // 2] left = [x for x in arr if x < pivot] middle = [x for x in arr if x == pivot] right = [x for x in arr if x > pivot] return quicksort(left) + middle + quicksort(right) Added type hints for the input and return type, plus a Google-style docstring.
Estimated: 14.0 tok/s decode · 13.8s TTFT (warm) · 35 tok/s prefill

What limits this setup

It fits through host-memory offload, and offload is the main reason performance drops.

CPU or host-memory offload is active

About 20% of the working set spills out of accelerator memory, which usually hurts latency and sustained decode throughput.

Very little memory headroom

You can run the model, but there is not much room left for longer context, bigger batches, extra apps, or future model updates.

Best improvement path

Remove offload with more accelerator memory

Prioritize a GPU or unified-memory tier that fits the whole model natively. Removing offload usually helps more than small compute gains.

Buy headroom, not only minimum fit

A slightly larger memory tier gives you safer context growth and makes the recommendation more future-proof.

Increase host RAM if you keep offloading

This setup may need roughly 30.0 GB of extra host RAM just for the offloaded portion, before OS and other tools.

Performance by workload

WorkloadGradeFitDecodeTTFTContext
ChatFToo heavy14.4 tok/s7348 ms4K
CodingFToo heavy14.0 tok/s13789 ms4K
Agentic CodingFToo heavy13.4 tok/s20990 ms4K
ReasoningFToo heavy14.0 tok/s16296 ms4K
RAGFToo heavy12.3 tok/s28698 ms4K

Quantization options

How Llama 3.1 405B (405B params) fits at each quantization level on B100 192GB (192.0 GB usable).

QuantBitsVRAMQualityFit
Q2_K
2
158.0 GB
LowF0
Q3_K_S
3
198.5 GB
LowF0
NVFP4
4

Get started

Copy-paste commands to run Llama 3.1 405B on your machine.

Run

ollama run llama3.1:405b

Upgrade options

Hardware that runs Llama 3.1 405B well

AMD Instinct MI350X 288GBBudget pick
288 GB VRAM (+96)
A
Makes the model fit on the accelerator instead of staying completely out of reach.25.9 tok/s decode

Makes the model fit on the accelerator instead of staying completely out of reach.

Removes host-memory offload, which is usually the single biggest latency and throughput win.

~$8,000 MSRP

AMD Instinct MI325X 256GBBest value
256 GB VRAM (+64)
A
Makes the model fit on the accelerator instead of staying completely out of reach.11.9 tok/s decode

Makes the model fit on the accelerator instead of staying completely out of reach.

Adds memory headroom for longer context windows and future model growth.

~$20,000 MSRP

Frequently asked questions

See all results for B100 192GBSee all hardware for Llama 3.1 405B
226.8 GB
Medium
F0
Q4_K_M
4
247.1 GB
MediumF0
Q5_K_M
5
291.6 GB
HighF0
Q6_K
6
332.1 GB
HighF0
Q8_0
8
433.4 GB
Very HighF0
F16
16
830.2 GB
MaximumF0

Remove offload with more accelerator memory. Prioritize a GPU or unified-memory tier that fits the whole model natively. Removing offload usually helps more than small compute gains.