Can Llama 3.3 70B run on AMD Instinct MI325X 256GB?

YES — Runs Great

A82Great

○Estimated from fit model

Llama 3.3 70B needs ~74.1 GB VRAM. AMD Instinct MI325X 256GB has 256.0 GB. With Q4_K_M quantization, expect ~112 tok/s.

Runtime: llama.cppCapacity: RoomyBandwidth: HighStack: StandardBottleneck: Balanced

Operating mode

Choose the run profile you care about

Interactive favors responsiveness, while light API and scale-out lean harder on serving readiness. The fit stays the same, but the recommendation lens changes.

Current mode

Balanced

Balanced for general local use. Keeps the ranking neutral across personal and serving workflows.

Capabilities:

Select quantization to explore

Q4_K_M (Medium quality) — 74.1 GB, 111.6 tok/s, Runs well

74.1 GB required256.0 GB available

29% VRAM used

Fit status

Runs well

Decode

111.6 tok/s

TTFT

1736 ms

Safe context

128K

Memory

74.1 GB / 256.0 GB

Memory breakdown

Weights42.7 GB

KV Cache4.9 GB

Runtime0.9 GB

Headroom25.6 GB

See how fast it feels

See how fast it feelsLlama 3.3 70B on AMD Instinct MI325X 256GB
1st promptCold start — includes initialization
>Solve: If a train travels at 60 mph for 2.5 hours, how far does it go?
Let me work through this step by step.

Given information:
 - Speed = 60 mph (miles per hour)
 - Time = 2.5 hours

Formula: Distance = Speed x Time

Calculation:
 Distance = 60 mph x 2.5 h
 = 150 miles

The train travels 150 miles.

Double-check: at 60 mph the train covers 60 miles each hour. In half an hour it covers 30 miles. So in 2.5 hours: 60 + 60 + 30 = 150 miles. Confirmed.
2nd promptWarm — model ready, no init overhead
>What if the train stops for 20 minutes halfway?
The stop doesn't change the total distance covered while moving, but it affects total trip time.

Breakdown:
 - First half: 1.25 hours at 60 mph = 75 miles
 - Stop: 20 minutes (no distance)
 - Second half: 1.25 hours at 60 mph = 75 miles

Total distance: 150 miles (same)
Total time: 2.5 h + 0.33 h = 2.83 hours
Average speed: 150 / 2.83 = 53 mph

The distance stays the same but average speed drops to 53 mph because of the stop.
Estimated: 111.6 tok/s decode · 1.7s TTFT (warm) · 279 tok/s prefill

What limits this setup

This setup is broadly balanced for this model.

No major red flags

This recommendation has enough memory headroom and acceptable estimated speed for the selected workload.

Best improvement path

Performance by workload

Workload	Grade	Fit	Decode	TTFT	Context
Chat	A	Runs well	111.6 tok/s	947 ms	128K
Coding	A	Runs well	111.6 tok/s	1736 ms	128K
Agentic Coding	A	Runs well	111.6 tok/s	2524 ms	128K
Reasoning	A	Runs well	111.6 tok/s	2051 ms	128K
RAG	A	Runs well	111.6 tok/s	3155 ms	128K

Quantization options

How Llama 3.3 70B (70B params) fits at each quantization level on AMD Instinct MI325X 256GB (256.0 GB usable).

Quant	Bits	VRAM	Quality	Fit
Q2_K	2	27.3 GB	Low	A72
Q3_K_S	3	34.3 GB	Low	A73
NVFP4	4	39.2 GB	Medium	A73
Q4_K_M	4	42.7 GB	Medium	A73
Q5_K_M	5	50.4 GB	High	A74
Q6_K	6	57.4 GB	High	A75
Q8_0	8	74.9 GB	Very High	A76
F16Best for your GPU	16	143.5 GB	Maximum	A82

Get started

Copy-paste commands to run Llama 3.3 70B on your machine.

Run

ollama run llama3.3

Your hardware

More models your AMD Instinct MI325X 256GB can run

Model	Params	Grade	Decode
👁 Alibaba Qwen 3.5 397B A17B	397B	A	39.2 tok/s
👁 Mistral Devstral 2 123B Instruct	123B	S	63.5 tok/s
👁 Alibaba Qwen 3.5 122B A10B	122B	S	176.1 tok/s
👁 DeepSeek DeepSeek V4 Flash	284B	S	94.4 tok/s
👁 Mistral Mistral Small 4 119B	119B	S	190.9 tok/s

Frequently asked questions

See all results for AMD Instinct MI325X 256GB See all hardware for Llama 3.3 70B

URL: https://willitrunai.com/can-run/llama-3.3-70b-on-instinct-mi325x-256gb

⇱ Llama 3.3 70B on AMD Instinct MI325X 256GB? YES