141 GB VRAM (+13)4800 GB/s (+1600)
A
Raises estimated decode speed by about 85%.97.4 tok/s decode
Raises estimated decode speed by about 85%.
~$30,000 MSRP
Can Mixtral 8x22B run on AMD Instinct MI250 128GB?
YES — Runs Great
B69Good
○Estimated from fit model
Mixtral 8x22B needs ~103.1 GB VRAM. AMD Instinct MI250 128GB has 128.0 GB. With Q4_K_M quantization, expect ~53 tok/s.
Runtime: llama.cppCapacity: RoomyBandwidth: HighStack: StandardBottleneck: Balanced
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Operating mode
Choose the run profile you care about
Interactive favors responsiveness, while light API and scale-out lean harder on serving readiness. The fit stays the same, but the recommendation lens changes.
Current mode
Balanced
Balanced for general local use. Keeps the ranking neutral across personal and serving workflows.
Select quantization to explore
Q4_K_M (Medium quality) — 103.1 GB, 52.6 tok/s, Runs well
103.1 GB required128.0 GB available
81% VRAM used
Fit status
Runs well
Decode
52.6 tok/s
TTFT
3682 ms
Safe context
66K
Memory
103.1 GB / 128.0 GB
Memory breakdown
Weights86.0 GB
KV Cache3.4 GB
Runtime0.9 GB
Headroom12.8 GB
See how fast it feels
See how fast it feelsMixtral 8x22B on AMD Instinct MI250 128GB
1st promptCold start — includes initialization
>Solve: If a train travels at 60 mph for 2.5 hours, how far does it go?
Let me work through this step by step.
Given information:
- Speed = 60 mph (miles per hour)
- Time = 2.5 hours
Formula: Distance = Speed x Time
Calculation:
Distance = 60 mph x 2.5 h
= 150 miles
The train travels 150 miles.
Double-check: at 60 mph the train covers 60 miles each hour. In half an hour it covers 30 miles. So in 2.5 hours: 60 + 60 + 30 = 150 miles. Confirmed.
2nd promptWarm — model ready, no init overhead
>What if the train stops for 20 minutes halfway?
The stop doesn't change the total distance covered while moving, but it affects total trip time.
Breakdown:
- First half: 1.25 hours at 60 mph = 75 miles
- Stop: 20 minutes (no distance)
- Second half: 1.25 hours at 60 mph = 75 miles
Total distance: 150 miles (same)
Total time: 2.5 h + 0.33 h = 2.83 hours
Average speed: 150 / 2.83 = 53 mph
The distance stays the same but average speed drops to 53 mph because of the stop.
Estimated: 52.6 tok/s decode · 3.7s TTFT (warm) · 131 tok/s prefill
What limits this setup
This setup is broadly balanced for this model.
No major red flags
This recommendation has enough memory headroom and acceptable estimated speed for the selected workload.
Best improvement path
Performance by workload
| Workload | Grade | Fit | Decode | TTFT | Context |
|---|---|---|---|---|---|
| Chat | B | Runs well | 52.6 tok/s | 2008 ms | 66K |
| Coding | B | Runs well | 52.6 tok/s | 3682 ms | 66K |
| Agentic Coding | B | Tight fit | 52.6 tok/s | 5356 ms | 66K |
| Reasoning | B | Runs well | 52.6 tok/s | 4352 ms | 66K |
| RAG | B | Tight fit | 52.6 tok/s | 6695 ms | 66K |
Quantization options
How Mixtral 8x22B (141B params) fits at each quantization level on AMD Instinct MI250 128GB (128.0 GB usable).
| Quant | Bits | VRAM | Quality | Fit |
|---|---|---|---|---|
Q2_K | 2 | 55.0 GB | Low | B59 |
Q3_K_S | 3 | 69.1 GB | Low | B61 |
NVFP4 | 4 | 79.0 GB | Medium | B61 |
Q4_K_M | 4 | 86.0 GB | Medium | B61 |
Q5_K_MBest for your GPU | 5 | 101.5 GB | High | B61 |
Q6_K | 6 | 115.6 GB | High | F0 |
Q8_0 | 8 | 150.9 GB | Very High | F0 |
F16 | 16 | 289.0 GB | Maximum | F0 |
Get started
Copy-paste commands to run Mixtral 8x22B on your machine.
Run
ollama run mixtral:8x22bUpgrade options