Can Mixtral 8x22B run on AMD Instinct MI325X 256GB?

YES — Runs Great

B65Good

○Estimated from fit model

Mixtral 8x22B needs ~115.9 GB VRAM. AMD Instinct MI325X 256GB has 256.0 GB. With Q4_K_M quantization, expect ~106 tok/s.

Runtime: llama.cppCapacity: RoomyBandwidth: HighStack: StandardBottleneck: Balanced

Operating mode

Choose the run profile you care about

Interactive favors responsiveness, while light API and scale-out lean harder on serving readiness. The fit stays the same, but the recommendation lens changes.

Current mode

Balanced

Balanced for general local use. Keeps the ranking neutral across personal and serving workflows.

Capabilities:

Select quantization to explore

Q4_K_M (Medium quality) — 115.9 GB, 105.8 tok/s, Runs well

115.9 GB required256.0 GB available

45% VRAM used

Fit status

Runs well

Decode

105.8 tok/s

TTFT

1829 ms

Safe context

66K

Memory

115.9 GB / 256.0 GB

Memory breakdown

Weights86.0 GB

KV Cache3.4 GB

Runtime0.9 GB

Headroom25.6 GB

See how fast it feels

See how fast it feelsMixtral 8x22B on AMD Instinct MI325X 256GB
1st promptCold start — includes initialization
>Solve: If a train travels at 60 mph for 2.5 hours, how far does it go?
Let me work through this step by step.

Given information:
 - Speed = 60 mph (miles per hour)
 - Time = 2.5 hours

Formula: Distance = Speed x Time

Calculation:
 Distance = 60 mph x 2.5 h
 = 150 miles

The train travels 150 miles.

Double-check: at 60 mph the train covers 60 miles each hour. In half an hour it covers 30 miles. So in 2.5 hours: 60 + 60 + 30 = 150 miles. Confirmed.
2nd promptWarm — model ready, no init overhead
>What if the train stops for 20 minutes halfway?
The stop doesn't change the total distance covered while moving, but it affects total trip time.

Breakdown:
 - First half: 1.25 hours at 60 mph = 75 miles
 - Stop: 20 minutes (no distance)
 - Second half: 1.25 hours at 60 mph = 75 miles

Total distance: 150 miles (same)
Total time: 2.5 h + 0.33 h = 2.83 hours
Average speed: 150 / 2.83 = 53 mph

The distance stays the same but average speed drops to 53 mph because of the stop.
Estimated: 105.8 tok/s decode · 1.8s TTFT (warm) · 265 tok/s prefill

What limits this setup

This setup is broadly balanced for this model.

No major red flags

This recommendation has enough memory headroom and acceptable estimated speed for the selected workload.

Best improvement path

Performance by workload

Workload	Grade	Fit	Decode	TTFT	Context
Chat	B	Runs well	105.8 tok/s	998 ms	66K
Coding	B	Runs well	105.8 tok/s	1829 ms	66K
Agentic Coding	B	Runs well	105.8 tok/s	2661 ms	66K
Reasoning	B	Runs well	105.8 tok/s	2162 ms	66K
RAG	B	Runs well	105.8 tok/s	3326 ms	66K

Quantization options

How Mixtral 8x22B (141B params) fits at each quantization level on AMD Instinct MI325X 256GB (256.0 GB usable).

Quant	Bits	VRAM	Quality	Fit
Q2_K	2	55.0 GB	Low	C54
Q3_K_S	3	69.1 GB	Low	B55
NVFP4	4

Get started

Copy-paste commands to run Mixtral 8x22B on your machine.

Run

ollama run mixtral:8x22b

Frequently asked questions

See all results for AMD Instinct MI325X 256GB See all hardware for Mixtral 8x22B

URL: https://willitrunai.com/can-run/mixtral-8x22b-on-instinct-mi325x-256gb

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