Can Phi-4 14B run on AMD Instinct MI325X 256GB?

YES — Runs Great

A77Great

○Estimated from fit model

Phi-4 14B needs ~38.1 GB VRAM. AMD Instinct MI325X 256GB has 256.0 GB. With Q4_K_M quantization, expect ~196 tok/s.

Runtime: llama.cppCapacity: RoomyBandwidth: HighStack: StandardBottleneck: Balanced

Operating mode

Choose the run profile you care about

Interactive favors responsiveness, while light API and scale-out lean harder on serving readiness. The fit stays the same, but the recommendation lens changes.

Current mode

Balanced

Balanced for general local use. Keeps the ranking neutral across personal and serving workflows.

Capabilities:

Select quantization to explore

Q4_K_M (Medium quality) — 38.1 GB, 196.0 tok/s, Runs well

38.1 GB required256.0 GB available

15% VRAM used

Fit status

Runs well

Decode

196.0 tok/s

TTFT

988 ms

Safe context

16K

Memory

38.1 GB / 256.0 GB

Memory breakdown

Weights8.5 GB

KV Cache3.1 GB

Runtime0.9 GB

Headroom25.6 GB

See how fast it feels

See how fast it feelsPhi-4 14B on AMD Instinct MI325X 256GB
1st promptCold start — includes initialization
>Solve: If a train travels at 60 mph for 2.5 hours, how far does it go?
Let me work through this step by step.

Given information:
 - Speed = 60 mph (miles per hour)
 - Time = 2.5 hours

Formula: Distance = Speed x Time

Calculation:
 Distance = 60 mph x 2.5 h
 = 150 miles

The train travels 150 miles.

Double-check: at 60 mph the train covers 60 miles each hour. In half an hour it covers 30 miles. So in 2.5 hours: 60 + 60 + 30 = 150 miles. Confirmed.
2nd promptWarm — model ready, no init overhead
>What if the train stops for 20 minutes halfway?
The stop doesn't change the total distance covered while moving, but it affects total trip time.

Breakdown:
 - First half: 1.25 hours at 60 mph = 75 miles
 - Stop: 20 minutes (no distance)
 - Second half: 1.25 hours at 60 mph = 75 miles

Total distance: 150 miles (same)
Total time: 2.5 h + 0.33 h = 2.83 hours
Average speed: 150 / 2.83 = 53 mph

The distance stays the same but average speed drops to 53 mph because of the stop.
Estimated: 196.0 tok/s decode · 988ms TTFT (warm) · 490 tok/s prefill

What limits this setup

This setup is broadly balanced for this model.

No major red flags

This recommendation has enough memory headroom and acceptable estimated speed for the selected workload.

Best improvement path

Performance by workload

Workload	Grade	Fit	Decode	TTFT	Context
Chat	A	Runs well	196.0 tok/s	539 ms	16K
Coding	A	Runs well	196.0 tok/s	988 ms	16K
Agentic Coding	A	Runs well	196.0 tok/s	1437 ms	16K
Reasoning	A	Runs well	196.0 tok/s	1167 ms	16K
RAG	A	Runs well	196.0 tok/s	1796 ms	16K

Quantization options

How Phi-4 14B (14B params) fits at each quantization level on AMD Instinct MI325X 256GB (256.0 GB usable).

Quant	Bits	VRAM	Quality	Fit
Q2_K	2	5.5 GB	Low	B68
Q3_K_S	3	6.9 GB	Low	B68
NVFP4	4	7.8 GB	Medium	B68
Q4_K_M	4	8.5 GB	Medium	B68
Q5_K_M	5	10.1 GB	High	B68
Q6_K	6	11.5 GB	High	B68
Q8_0	8	15.0 GB	Very High	B68
F16Best for your GPU	16	28.7 GB	Maximum	B69

Get started

Copy-paste commands to run Phi-4 14B on your machine.

Run

ollama run phi4

Your hardware

More models your AMD Instinct MI325X 256GB can run

Model	Params	Grade	Decode
👁 Alibaba Qwen 3.5 397B A17B	397B	A	39.2 tok/s
👁 Mistral Devstral 2 123B Instruct	123B	S	63.5 tok/s
👁 Alibaba Qwen3-Coder 30B A3B Instruct	30.5B	S	662.3 tok/s
👁 Alibaba Qwen 3.5 27B	27B	S	287.2 tok/s
👁 Alibaba Qwen 3.6 27B	27B	S	179 tok/s

Frequently asked questions

See all results for AMD Instinct MI325X 256GB See all hardware for Phi-4 14B

URL: https://willitrunai.com/can-run/phi-4-14b-on-instinct-mi325x-256gb

⇱ Phi-4 14B on AMD Instinct MI325X 256GB? YES