Can Qwen 2.5 72B run on B100 192GB?

YES — Runs Great

A81Great

○Estimated from fit model

Qwen 2.5 72B needs ~69.2 GB VRAM. B100 192GB has 192.0 GB. With Q4_K_M quantization, expect ~166 tok/s.

Runtime: OllamaCapacity: RoomyBandwidth: HighStack: BasicBottleneck: Balanced

Operating mode

Choose the run profile you care about

Interactive favors responsiveness, while light API and scale-out lean harder on serving readiness. The fit stays the same, but the recommendation lens changes.

Current mode

Balanced

Balanced for general local use. Keeps the ranking neutral across personal and serving workflows.

Capabilities:

Select quantization to explore

Q4_K_M (Medium quality) — 69.2 GB, 166.4 tok/s, Runs well

69.2 GB required192.0 GB available

36% VRAM used

Fit status

Runs well

Decode

166.4 tok/s

TTFT

1164 ms

Safe context

131K

Memory

69.2 GB / 192.0 GB

Memory breakdown

Weights43.9 GB

KV Cache4.9 GB

Runtime1.2 GB

Headroom19.2 GB

See how fast it feels

See how fast it feelsQwen 2.5 72B on B100 192GB
1st promptCold start — includes initialization
>Solve: If a train travels at 60 mph for 2.5 hours, how far does it go?
Let me work through this step by step.

Given information:
 - Speed = 60 mph (miles per hour)
 - Time = 2.5 hours

Formula: Distance = Speed x Time

Calculation:
 Distance = 60 mph x 2.5 h
 = 150 miles

The train travels 150 miles.

Double-check: at 60 mph the train covers 60 miles each hour. In half an hour it covers 30 miles. So in 2.5 hours: 60 + 60 + 30 = 150 miles. Confirmed.
2nd promptWarm — model ready, no init overhead
>What if the train stops for 20 minutes halfway?
The stop doesn't change the total distance covered while moving, but it affects total trip time.

Breakdown:
 - First half: 1.25 hours at 60 mph = 75 miles
 - Stop: 20 minutes (no distance)
 - Second half: 1.25 hours at 60 mph = 75 miles

Total distance: 150 miles (same)
Total time: 2.5 h + 0.33 h = 2.83 hours
Average speed: 150 / 2.83 = 53 mph

The distance stays the same but average speed drops to 53 mph because of the stop.
Estimated: 166.4 tok/s decode · 1.2s TTFT (warm) · 416 tok/s prefill

What limits this setup

This setup is broadly balanced for this model.

No major red flags

This recommendation has enough memory headroom and acceptable estimated speed for the selected workload.

Best improvement path

Performance by workload

Workload	Grade	Fit	Decode	TTFT	Context
Chat	A	Runs well	166.4 tok/s	635 ms	131K
Coding	A	Runs well	166.4 tok/s	1164 ms	131K
Agentic Coding	A	Runs well	166.4 tok/s	1692 ms	131K
Reasoning	A	Runs well	153.0 tok/s	1495 ms	131K
RAG	A	Runs well	166.4 tok/s	2115 ms	131K

Quantization options

How Qwen 2.5 72B (72B params) fits at each quantization level on B100 192GB (192.0 GB usable).

Quant	Bits	VRAM	Quality	Fit
Q2_K	2	28.1 GB	Low	B70
Q3_K_S	3	35.3 GB	Low	A71
NVFP4	4

Get started

Copy-paste commands to run Qwen 2.5 72B on your machine.

Run

ollama run qwen2.5:72b

Your hardware

More models your B100 192GB can run

Model	Params	Grade	Decode	Capabilities
👁 Mistral Devstral 2 123B Instruct	123B	S	97.4 tok/s
👁 Alibaba Qwen 3.5 122B A10B	122B	S

Frequently asked questions

See all results for B100 192GB See all hardware for Qwen 2.5 72B

URL: https://willitrunai.com/can-run/qwen-2.5-72b-on-b100-192gb

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