Can Qwen 2.5 72B run on AMD Instinct MI350X 288GB?

YES — Runs Great

A79Great

○Estimated from fit model

Qwen 2.5 72B needs ~78.5 GB VRAM. AMD Instinct MI350X 288GB has 288.0 GB. With Q4_K_M quantization, expect ~145 tok/s.

Runtime: llama.cppCapacity: RoomyBandwidth: HighStack: StandardBottleneck: Balanced

Operating mode

Choose the run profile you care about

Interactive favors responsiveness, while light API and scale-out lean harder on serving readiness. The fit stays the same, but the recommendation lens changes.

Current mode

Balanced

Balanced for general local use. Keeps the ranking neutral across personal and serving workflows.

Capabilities:

Select quantization to explore

Q4_K_M (Medium quality) — 78.5 GB, 144.6 tok/s, Runs well

78.5 GB required288.0 GB available

27% VRAM used

Fit status

Runs well

Decode

144.6 tok/s

TTFT

1339 ms

Safe context

131K

Memory

78.5 GB / 288.0 GB

Memory breakdown

Weights43.9 GB

KV Cache4.9 GB

Runtime0.9 GB

Headroom28.8 GB

See how fast it feels

See how fast it feelsQwen 2.5 72B on AMD Instinct MI350X 288GB
1st promptCold start — includes initialization
>Solve: If a train travels at 60 mph for 2.5 hours, how far does it go?
Let me work through this step by step.

Given information:
 - Speed = 60 mph (miles per hour)
 - Time = 2.5 hours

Formula: Distance = Speed x Time

Calculation:
 Distance = 60 mph x 2.5 h
 = 150 miles

The train travels 150 miles.

Double-check: at 60 mph the train covers 60 miles each hour. In half an hour it covers 30 miles. So in 2.5 hours: 60 + 60 + 30 = 150 miles. Confirmed.
2nd promptWarm — model ready, no init overhead
>What if the train stops for 20 minutes halfway?
The stop doesn't change the total distance covered while moving, but it affects total trip time.

Breakdown:
 - First half: 1.25 hours at 60 mph = 75 miles
 - Stop: 20 minutes (no distance)
 - Second half: 1.25 hours at 60 mph = 75 miles

Total distance: 150 miles (same)
Total time: 2.5 h + 0.33 h = 2.83 hours
Average speed: 150 / 2.83 = 53 mph

The distance stays the same but average speed drops to 53 mph because of the stop.
Estimated: 144.6 tok/s decode · 1.3s TTFT (warm) · 362 tok/s prefill

What limits this setup

This setup is broadly balanced for this model.

No major red flags

This recommendation has enough memory headroom and acceptable estimated speed for the selected workload.

Best improvement path

Performance by workload

Workload	Grade	Fit	Decode	TTFT	Context
Chat	A	Runs well	144.6 tok/s	730 ms	131K
Coding	A	Runs well	144.6 tok/s	1339 ms	131K
Agentic Coding	A	Runs well	144.6 tok/s	1947 ms	131K
Reasoning	A	Runs well	144.6 tok/s	1582 ms	131K
RAG	A	Runs well	144.6 tok/s	2434 ms	131K

Quantization options

How Qwen 2.5 72B (72B params) fits at each quantization level on AMD Instinct MI350X 288GB (288.0 GB usable).

Quant	Bits	VRAM	Quality	Fit
Q2_K	2	28.1 GB	Low	B68
Q3_K_S	3	35.3 GB	Low	B69
NVFP4	4	40.3 GB	Medium	B69
Q4_K_M	4	43.9 GB	Medium	B70
Q5_K_M	5	51.8 GB	High	A70
Q6_K	6	59.0 GB	High	A71
Q8_0	8	77.0 GB	Very High	A72
F16Best for your GPU	16	147.6 GB	Maximum	A77

Get started

Copy-paste commands to run Qwen 2.5 72B on your machine.

Run

ollama run qwen2.5:72b

Your hardware

More models your AMD Instinct MI350X 288GB can run

Model	Params	Grade	Decode
👁 Alibaba Qwen 3.5 397B A17B	397B	S	78.9 tok/s
👁 Mistral Devstral 2 123B Instruct	123B	S	84.6 tok/s
👁 Alibaba Qwen 3.5 122B A10B	122B	S	234.8 tok/s
👁 DeepSeek DeepSeek V4 Flash	284B	S	125.8 tok/s
👁 Mistral Mistral Small 4 119B	119B	S	254.6 tok/s

Frequently asked questions

See all results for AMD Instinct MI350X 288GB See all hardware for Qwen 2.5 72B

URL: https://willitrunai.com/can-run/qwen-2.5-72b-on-instinct-mi350x-288gb

⇱ Qwen 2.5 72B on AMD Instinct MI350X 288GB? YES