Can Qwen 2.5 VL 72B run on AMD Instinct MI250X 128GB?

YES — Runs Great

S91Excellent

○Estimated from fit model

Qwen 2.5 VL 72B needs ~62.5 GB VRAM. AMD Instinct MI250X 128GB has 128.0 GB. With Q4_K_M quantization, expect ~57 tok/s.

Runtime: llama.cppCapacity: RoomyBandwidth: HighStack: StandardBottleneck: Balanced

Operating mode

Choose the run profile you care about

Interactive favors responsiveness, while light API and scale-out lean harder on serving readiness. The fit stays the same, but the recommendation lens changes.

Current mode

Balanced

Balanced for general local use. Keeps the ranking neutral across personal and serving workflows.

Capabilities:

Select quantization to explore

Q4_K_M (Medium quality) — 62.5 GB, 61.8 tok/s, Runs well

62.5 GB required128.0 GB available

49% VRAM used

Fit status

Runs well

Decode

61.8 tok/s

TTFT

3133 ms

Safe context

33K

Memory

62.5 GB / 128.0 GB

Memory breakdown

Weights43.9 GB

KV Cache4.9 GB

Runtime0.9 GB

Headroom12.8 GB

See how fast it feels

See how fast it feelsQwen 2.5 VL 72B on AMD Instinct MI250X 128GB
1st promptCold start — includes initialization
>Solve: If a train travels at 60 mph for 2.5 hours, how far does it go?
Let me work through this step by step.

Given information:
 - Speed = 60 mph (miles per hour)
 - Time = 2.5 hours

Formula: Distance = Speed x Time

Calculation:
 Distance = 60 mph x 2.5 h
 = 150 miles

The train travels 150 miles.

Double-check: at 60 mph the train covers 60 miles each hour. In half an hour it covers 30 miles. So in 2.5 hours: 60 + 60 + 30 = 150 miles. Confirmed.
2nd promptWarm — model ready, no init overhead
>What if the train stops for 20 minutes halfway?
The stop doesn't change the total distance covered while moving, but it affects total trip time.

Breakdown:
 - First half: 1.25 hours at 60 mph = 75 miles
 - Stop: 20 minutes (no distance)
 - Second half: 1.25 hours at 60 mph = 75 miles

Total distance: 150 miles (same)
Total time: 2.5 h + 0.33 h = 2.83 hours
Average speed: 150 / 2.83 = 53 mph

The distance stays the same but average speed drops to 53 mph because of the stop.
Estimated: 61.8 tok/s decode · 3.1s TTFT (warm) · 155 tok/s prefill

What limits this setup

This setup is broadly balanced for this model.

No major red flags

This recommendation has enough memory headroom and acceptable estimated speed for the selected workload.

Best improvement path

Performance by workload

Workload	Grade	Fit	Decode	TTFT	Context
Chat	S	Runs well	61.8 tok/s	1709 ms	33K
Coding	S	Runs well	56.8 tok/s	3407 ms	33K
Agentic Coding	S	Runs well	61.8 tok/s	4556 ms	33K
Reasoning	S	Runs well	61.8 tok/s	3702 ms	33K
RAG	S	Runs well	61.8 tok/s	5695 ms	33K

Quantization options

How Qwen 2.5 VL 72B (72B params) fits at each quantization level on AMD Instinct MI250X 128GB (128.0 GB usable).

Quant	Bits	VRAM	Quality	Fit
Q2_K	2	28.1 GB	Low	A81
Q3_K_S	3	35.3 GB	Low	A82
NVFP4	4

Get started

Copy-paste commands to run Qwen 2.5 VL 72B on your machine.

Run

lms load Qwen2.5-VL-72B-Instruct && lms server start

Your hardware

More models your AMD Instinct MI250X 128GB can run

Model	Params	Grade	Decode	Capabilities
👁 Mistral Devstral 2 123B Instruct	123B	S	36.2 tok/s
👁 Alibaba Qwen 3.5 122B A10B	122B	S

Frequently asked questions

See all results for AMD Instinct MI250X 128GB See all hardware for Qwen 2.5 VL 72B

URL: https://willitrunai.com/can-run/qwen-2.5-vl-72b-on-instinct-mi250x-128gb

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