Can Qwen 2.5 VL 72B run on Radeon Pro W7900 48GB?

BARELY — Tight on Memory

A76Great

○Estimated from fit model

Qwen 2.5 VL 72B needs ~54.5 GB VRAM. Radeon Pro W7900 48GB has 48.0 GB. With Q4_K_M quantization, expect ~7 tok/s.

Runtime: llama.cppCapacity: OffloadBandwidth: HighStack: StandardBottleneck: Host offload

Operating mode

Choose the run profile you care about

Interactive favors responsiveness, while light API and scale-out lean harder on serving readiness. The fit stays the same, but the recommendation lens changes.

Current mode

Balanced

Balanced for general local use. Keeps the ranking neutral across personal and serving workflows.

Capabilities:

Select quantization to explore

Q4_K_M (Medium quality) — 54.5 GB, 7.2 tok/s, Very compromised (needs ~5.2 GB host RAM)

54.5 GB required48.0 GB available

114% VRAM needed

6.5 GB over capacity — needs offload or smaller quantization

Fit status

Very compromised (needs ~5.2 GB host RAM)

Decode

7.2 tok/s

TTFT

26721 ms

Safe context

Memory

54.5 GB / 48.0 GB

Offload

10%

Memory breakdown

Weights43.9 GB

KV Cache4.9 GB

Runtime0.9 GB

Headroom4.8 GB

See how fast it feels

See how fast it feelsQwen 2.5 VL 72B on Radeon Pro W7900 48GB
1st promptCold start — includes initialization
>Solve: If a train travels at 60 mph for 2.5 hours, how far does it go?
Let me work through this step by step.

Given information:
 - Speed = 60 mph (miles per hour)
 - Time = 2.5 hours

Formula: Distance = Speed x Time

Calculation:
 Distance = 60 mph x 2.5 h
 = 150 miles

The train travels 150 miles.

Double-check: at 60 mph the train covers 60 miles each hour. In half an hour it covers 30 miles. So in 2.5 hours: 60 + 60 + 30 = 150 miles. Confirmed.
2nd promptWarm — model ready, no init overhead
>What if the train stops for 20 minutes halfway?
The stop doesn't change the total distance covered while moving, but it affects total trip time.

Breakdown:
 - First half: 1.25 hours at 60 mph = 75 miles
 - Stop: 20 minutes (no distance)
 - Second half: 1.25 hours at 60 mph = 75 miles

Total distance: 150 miles (same)
Total time: 2.5 h + 0.33 h = 2.83 hours
Average speed: 150 / 2.83 = 53 mph

The distance stays the same but average speed drops to 53 mph because of the stop.
Estimated: 7.2 tok/s decode · 26.7s TTFT (warm) · 18 tok/s prefill

What limits this setup

It fits through host-memory offload, and offload is the main reason performance drops.

CPU or host-memory offload is active

About 10% of the working set spills out of accelerator memory, which usually hurts latency and sustained decode throughput.

Very little memory headroom

You can run the model, but there is not much room left for longer context, bigger batches, extra apps, or future model updates.

Best improvement path

Remove offload with more accelerator memory

Prioritize a GPU or unified-memory tier that fits the whole model natively. Removing offload usually helps more than small compute gains.

Buy headroom, not only minimum fit

A slightly larger memory tier gives you safer context growth and makes the recommendation more future-proof.

Increase host RAM if you keep offloading

This setup may need roughly 5.2 GB of extra host RAM just for the offloaded portion, before OS and other tools.

Performance by workload

Workload	Grade	Fit	Decode	TTFT	Context
Chat	A	Very compromised (needs ~3.4 GB host RAM)	8.0 tok/s	13235 ms	4K
Coding	A	Very compromised (needs ~5.2 GB host RAM)	7.2 tok/s	26721 ms	4K
Agentic Coding	F	Too heavy	6.0 tok/s	46561 ms	4K
Reasoning	A	Very compromised (needs ~5.2 GB host RAM)	7.2 tok/s	31580 ms	4K
RAG	F	Too heavy	6.0 tok/s	58202 ms	4K

Quantization options

How Qwen 2.5 VL 72B (72B params) fits at each quantization level on Radeon Pro W7900 48GB (48.0 GB usable).

Quant	Bits	VRAM	Quality	Fit
Q2_K	2	28.1 GB	Low	S88
Q3_K_SBest for your GPU	3	35.3 GB	Low	S88
NVFP4	4	40.3 GB	Medium	F0
Q4_K_M	4	43.9 GB	Medium	F0
Q5_K_M	5	51.8 GB	High	F0
Q6_K	6	59.0 GB	High	F0
Q8_0	8	77.0 GB	Very High	F0
F16	16	147.6 GB	Maximum	F0

Get started

Copy-paste commands to run Qwen 2.5 VL 72B on your machine.

Run

lms load Qwen2.5-VL-72B-Instruct && lms server start

Frequently asked questions

See all results for Radeon Pro W7900 48GB See all hardware for Qwen 2.5 VL 72B

URL: https://willitrunai.com/can-run/qwen-2.5-vl-72b-on-radeon-pro-w7900-48gb

⇱ Qwen 2.5 VL 72B on Radeon Pro W7900 48GB? YES